Abstract
Laboratory strains of mice are thought to be derived from wild populations of Mus domesticus. Many instances of non-domesticus genetic information fixed in these strains have been described, however, and the amount of strain-to-strain genetic variation exceeds that found in wild domesticus populations. In order to estimate the extent of the non-domesticus contribution to laboratory mouse genomes, and to determine whether it could account for observed variation, we have used computer simulations to investigate the properties of genetically marked chromosomal segments and the distribution of residual allogenicity at various times during inbreeding. A locus or chromosomal segment is allogenic if it is unfixed within a lineage at a given time. The odds of fixation of a foreign chromosome segment are predicted to be an exponentially decreasing function of its length. The median segment length is predicted to be 17 centimorgans. Available data for markers of chromosomes 1, 9 and 12 in recombinant inbred strain sets conform to these predictions. Together, the results suggest that introgression of non-domesticus chromosomes and segregation of residual allogenicity are sufficient to account for the genetic diversity observed among inbred mouse strains and substrains.
Full Text
The Full Text of this article is available as a PDF (890.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bonhomme F., Catalan J., Britton-Davidian J., Chapman V. M., Moriwaki K., Nevo E., Thaler L. Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275–303. doi: 10.1007/BF00484229. [DOI] [PubMed] [Google Scholar]
- Chang H. C., Seki T., Moriuchi T., Silver J. Isolation and characterization of mouse Thy-1 genomic clones. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3819–3823. doi: 10.1073/pnas.82.11.3819. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chattopadhyay S. K., Lander M. R., Rowe W. P. Close similarity between endogenous ecotropic virus of Mus musculus molossinus and AKR virus. J Virol. 1980 Nov;36(2):499–505. doi: 10.1128/jvi.36.2.499-505.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fitch W. M., Atchley W. R. Evolution in inbred strains of mice appears rapid. Science. 1985 Jun 7;228(4704):1169–1175. doi: 10.1126/science.4001935. [DOI] [PubMed] [Google Scholar]
- Hogarth P. M., McKenzie I. F., Lanier L., Bailey D. W., Taylor B. A. Location of Ly-7 on mouse chromosome 12. Immunogenetics. 1984;19(6):539–543. doi: 10.1007/BF00403445. [DOI] [PubMed] [Google Scholar]
- Lieberman R., Potter M. Polymorphism of heavy-chain genes in immunoglobulins of wild mice. Science. 1966 Oct 28;154(3748):535–537. doi: 10.1126/science.154.3748.535. [DOI] [PubMed] [Google Scholar]
- Miller O. J., Miller D. A. Cytogenetics of the mouse. Annu Rev Genet. 1975;9:285–303. doi: 10.1146/annurev.ge.09.120175.001441. [DOI] [PubMed] [Google Scholar]
- Miyashita N., Moriwaki K., Minezawa M., Yonekawa H., Bonhomme F., Migita S., Yu Z. C., Lu D. Y., Cho W. S., Thohari M. Allelic constitution of the hemoglobin beta chain in wild populations of the house mouse, Mus musculus. Biochem Genet. 1985 Dec;23(11-12):975–986. doi: 10.1007/BF00499941. [DOI] [PubMed] [Google Scholar]
- Polani P. E. Centromere localization at meiosis and the position of chiasmata in the male and female mouse. Chromosoma. 1972;36(4):343–374. doi: 10.1007/BF00336793. [DOI] [PubMed] [Google Scholar]
- Shih L. Y., Suslak L., Rosin I., Searle B. M., Desposito F. Gene dosage studies supporting localization of the structural gene for galactose-1-phosphate uridyl transferase (GALT) to band p13 of chromosome 9. Am J Med Genet. 1984 Nov;19(3):539–543. doi: 10.1002/ajmg.1320190316. [DOI] [PubMed] [Google Scholar]