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. 1988 Jun;119(2):365–375. doi: 10.1093/genetics/119.2.365

X Chromosome Duplications Affect a Region of the Chromosome They Do Not Duplicate in Caenorhabditis Elegans

P M Meneely 1, K D Nordstrom 1
PMCID: PMC1203419  PMID: 3396870

Abstract

X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress an X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, although these two genes are located in a region of the X chromosome that is not duplicated. The effects do not depend on the region of the X chromosome duplicated and is stronger in strains with two doses of a duplication than in strains with one dose. This is evidence for a general elevation of X-linked gene expression in strains carrying X-chromosome duplications, consistent with the hypothesis that the duplications titrate a repressor acting on many X-linked genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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