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. 1988 Jul;119(3):491–497. doi: 10.1093/genetics/119.3.491

Genetic and Physical Analysis of the M26 Recombination Hotspot of Schizosaccharomyces Pombe

A S Ponticelli 1, E P Sena 1, G R Smith 1
PMCID: PMC1203434  PMID: 3402730

Abstract

The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate ade6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G -> T nucleotide change, that M26 stimulated recombination within ade6 but not at other distant loci, and that M26 stimulated meiotic but not mitotic recombination. In addition, M26 stimulated recombination within ade6 when M26 is homozygous; this result demonstrates that a base-pair mismatch at the M26 site was not required for the stimulation. These results are consistent with the ade6-M26 mutation creating a meiotic recombination initiation site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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