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. 1989 Apr;121(4):787–794. doi: 10.1093/genetics/121.4.787

Insertion of a Copia Element 5' to the Drosophila Melanogaster Alcohol Dehydrogenase Gene (Adh) Is Associated with Altered Developmental and Tissue-Specific Patterns of Expression

D J Strand 1, J F McDonald 1
PMCID: PMC1203661  PMID: 2470641

Abstract

The Drosophila melanogaster alcohol dehydrogenase gene (adh) is under the control of two separate promoters (proximal and distal) which are preferentially utilized at the larval and adult life stages, respectively. A variant alcohol dehydrogenase allele (RI-42) isolated from a natural population contains a copia retroviral-like transposable element inserted 240 bp upstream from the distal (adult) adh transcriptional start site. Levels of adh transcripts in the RI-42 variant are reduced in tissues and at life stages where copia is actively expressed and are affected in trans- by mutant alleles at the suppressor-of-white-apricot (su(w(a))) and suppressor-of-forked (su(f)) loci. These suppressor genes have no effect on adh expression in wild-type Drosophila.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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