Abstract
Making use of deficiencies, inversions and translocations, we have genetically dissected the region 95E to 96F of Drosophila melanogaster. We localized cytologically the loci abnormal spindle (asp: 3-85.2: 96A20-25;96B1-10) and M(3)96C(2) (96C1;96C5). We have also found several new phenotypes associated with lesions in the 95E to 97B region: (1) Minute(3)96A (M(3)96A) is a haplo-insufficient phenotype of thin and short bristles presented by individuals deficient for the region 95E6-8;96A1-5. (2) abdominal-one reduced (aor) shows two different phenotypes associated with the distal breakpoint of In(3R)Ubx(7L) (89E;96A1-7). One is the increase of the Ubx phenotype, but its effect requires the presence of lesions in Ubx. The other phenotype is a drastic reduction or disappearance of the first abdominal segment. Both phenotypes might be due to lesions in the same gene. (3) metaphase arrest (mar) is associated with the breakpoint of the T(Y;3)B197 (96B1-10) and produces a phenotype typical of mitotic mutants with arrest of the cell cycle during prometaphase or metaphase. There is another region localized in 97B which interacts with asp: in a background homozygous for asp, three doses of this region enhance the asp phenotype.
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Selected References
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- Anderson K. V., Jürgens G., Nüsslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell. 1985 Oct;42(3):779–789. doi: 10.1016/0092-8674(85)90274-0. [DOI] [PubMed] [Google Scholar]
- Broderick D. J., Roberts P. A. Localization of minutes to specific polytene chromosome bands by means of overlapping duplications. Genetics. 1982 Sep;102(1):71–74. doi: 10.1093/genetics/102.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
- González C., Casal J., Ripoll P. Functional monopolar spindles caused by mutation in mgr, a cell division gene of Drosophila melanogaster. J Cell Sci. 1988 Jan;89(Pt 1):39–47. doi: 10.1242/jcs.89.1.39. [DOI] [PubMed] [Google Scholar]
- Green M. M. Mapping a Drosophila melanogaster "controlling element" by interallelic crossing over. Genetics. 1969 Feb;61(2):423–428. doi: 10.1093/genetics/61.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindsley D. L., Sandler L., Baker B. S., Carpenter A. T., Denell R. E., Hall J. C., Jacobs P. A., Miklos G. L., Davis B. K., Gethmann R. C. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. doi: 10.1093/genetics/71.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reinke R., Zipursky S. L. Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development. Cell. 1988 Oct 21;55(2):321–330. doi: 10.1016/0092-8674(88)90055-4. [DOI] [PubMed] [Google Scholar]
- Ripoll P., Pimpinelli S., Valdivia M. M., Avila J. A cell division mutant of Drosophila with a functionally abnormal spindle. Cell. 1985 Jul;41(3):907–912. doi: 10.1016/s0092-8674(85)80071-4. [DOI] [PubMed] [Google Scholar]
- Shearn A. The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related. Genetics. 1989 Mar;121(3):517–525. doi: 10.1093/genetics/121.3.517. [DOI] [PMC free article] [PubMed] [Google Scholar]