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. 1990 Mar;124(3):497–504. doi: 10.1093/genetics/124.3.497

Srd1, a Saccharomyces Cerevisiae Suppressor of the Temperature-Sensitive Pre-Rrna Processing Defect of Rrp1-1

G R Fabian 1, S M Hess 1, A K Hopper 1
PMCID: PMC1203943  PMID: 2179050

Abstract

We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S rRNA, and a nonconditional increase in sensitivity to several aminoglycoside antibiotics. All srd1 alleles identified are recessive and apparently specific to the rrp1-1 mutation. Although a mutation of SRD1 suppresses the pre-rRNA processing defect, drug sensitivity and thermolethality of a point mutation of RRP1, it is unable to suppress a rrp1-disruption allele. We suggest that the SRD1 gene product either interacts with or regulates the RRP1 product.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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