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. 1990 Sep;126(1):201–205. doi: 10.1093/genetics/126.1.201

Major Effects on Teratogen-Induced Facial Clefting in Mice Determined by a Single Genetic Region

J Karolyi 1, R P Erickson 1, S Liu 1, L Killewald 1
PMCID: PMC1204124  PMID: 2227380

Abstract

A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing <0.7% of the genome, was transferred from one strain to the other by the construction of congenic strains. 6-Aminonicotinamide-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate are also influenced by this genetic region but not as strongly. In both cases the susceptible strain became quite resistant to the teratogen-induced clefting when the N-acetyl transferase region of chromosome 8 was transferred. However, this chromosomal region does not make the resistant strain susceptible to these two teratogens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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