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. 1990 Nov;126(3):639–650. doi: 10.1093/genetics/126.3.639

Genetics of 51d-52a, a Region Containing Several Maternal-Effect Genes and Two Maternal-Specific Transcripts in Drosophila

E M Underwood 1, A S Briot 1, K Z Doll 1, R L Ludwiczak 1, D C Otteson 1, J Tower 1, K B Vessey 1, K Yu 1
PMCID: PMC1204219  PMID: 2249762

Abstract

Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-sterile and lethal mutations isolated. A total of twelve complementation groups have been identified, four of which are defined exclusively by female-sterile alleles. Only one visible mutation was isolated, a recessive temperature-sensitive allele of Thickened-arista (Ta(rts)). Several of the seven lethal loci display an embryonic lethal phase. Three of the four female-sterile loci affect chorion structure with one resulting in underamplification of the chorion genes, and two (possibly three) of the four female-steriles affect nuclear division/DNA replication. Thus it appears that this is a ``developmentally important'' region, possibly representing a clustering of genes involved in either DNA replication or nuclear division.

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Selected References

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