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. 1991 Jun;128(2):471–486. doi: 10.1093/genetics/128.2.471

Models of Repression of Transposition in P-M Hybrid Dysgenesis by P Cytotype and by Zygotically Encoded Repressor Proteins

JFY Brookfield 1
PMCID: PMC1204483  PMID: 1649073

Abstract

By analytical theory and computer simulation the expected evolutionary dynamics of P transposable element spread in an infinite population are investigated. The analysis is based on the assumption that, unlike transposable elements which move via RNA intermediates, the harmful effects of P elements arise primarily in the act of transposition, and that this causes their evolutionary dynamics to be unusual. It is suggested that a situation of transposition-selection balance will be superceded by the buildup of a cytoplasmically inherited repression or by the elimination of active transposase-encoding elements from the chromosomes, a process which may be accompanied by the evolution of elements which encode proteins which repress transposition.

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Selected References

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  1. Ajioka J. W., Eanes W. F. The accumulation of P-elements on the tip of the X chromosome in populations of Drosophila melanogaster. Genet Res. 1989 Feb;53(1):1–6. doi: 10.1017/s0016672300027798. [DOI] [PubMed] [Google Scholar]
  2. Anxolabéhère D., Kidwell M. G., Periquet G. Molecular characteristics of diverse populations are consistent with the hypothesis of a recent invasion of Drosophila melanogaster by mobile P elements. Mol Biol Evol. 1988 May;5(3):252–269. doi: 10.1093/oxfordjournals.molbev.a040491. [DOI] [PubMed] [Google Scholar]
  3. Anxolabéhère D., Nouaud D., Périquet G., Tchen P. P-element distribution in Eurasian populations of Drosophila melanogaster: A genetic and molecular analysis. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5418–5422. doi: 10.1073/pnas.82.16.5418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baker B., Schell J., Lörz H., Fedoroff N. Transposition of the maize controlling element "Activator" in tobacco. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4844–4848. doi: 10.1073/pnas.83.13.4844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Black D. M., Jackson M. S., Kidwell M. G., Dover G. A. KP elements repress P-induced hybrid dysgenesis in Drosophila melanogaster. EMBO J. 1987 Dec 20;6(13):4125–4135. doi: 10.1002/j.1460-2075.1987.tb02758.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brookfield J. F. Interspersed repetitive DNA sequences are unlikely to be parasitic. J Theor Biol. 1982 Jan 21;94(2):281–299. doi: 10.1016/0022-5193(82)90313-7. [DOI] [PubMed] [Google Scholar]
  7. Charlesworth B., Langley C. H. The evolution of self-regulated transposition of transposable elements. Genetics. 1986 Feb;112(2):359–383. doi: 10.1093/genetics/112.2.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Daniels S. B., Clark S. H., Kidwell M. G., Chovnick A. Genetic transformation of Drosophila melanogaster with an autonomous P element: phenotypic and molecular analyses of long-established transformed lines. Genetics. 1987 Apr;115(4):711–723. doi: 10.1093/genetics/115.4.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Engels W. R., Benz W. K., Preston C. R., Graham P. L., Phillis R. W., Robertson H. M. Somatic effects of P element activity in Drosophila melanogaster: pupal lethality. Genetics. 1987 Dec;117(4):745–757. doi: 10.1093/genetics/117.4.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Engels W. R. On the evolution and population genetics of hybrid-dysgenesis-causing transposable elements in Drosophila. Philos Trans R Soc Lond B Biol Sci. 1986 Jan 29;312(1154):205–215. doi: 10.1098/rstb.1986.0002. [DOI] [PubMed] [Google Scholar]
  11. Engels W. R. The P family of transposable elements in Drosophila. Annu Rev Genet. 1983;17:315–344. doi: 10.1146/annurev.ge.17.120183.001531. [DOI] [PubMed] [Google Scholar]
  12. Finnegan D. J. Transposable elements in eukaryotes. Int Rev Cytol. 1985;93:281–326. doi: 10.1016/s0074-7696(08)61376-5. [DOI] [PubMed] [Google Scholar]
  13. Kaplan N. L., Brookfield J. F. The effect of homozygosity of selective differences between sites of transposable elements. Theor Popul Biol. 1983 Jun;23(3):273–280. doi: 10.1016/0040-5809(83)90018-7. [DOI] [PubMed] [Google Scholar]
  14. Kaplan N. L., Brookfield J. F. Transposable Elements in Mendelian Populations. III. Statistical Results. Genetics. 1983 Jul;104(3):485–495. doi: 10.1093/genetics/104.3.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kaplan N., Darden T., Langley C. H. Evolution and extinction of transposable elements in Mendelian populations. Genetics. 1985 Feb;109(2):459–480. doi: 10.1093/genetics/109.2.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Langley C. H., Brookfield J. F., Kaplan N. Transposable elements in mendelian populations. I. A theory. Genetics. 1983 Jul;104(3):457–471. doi: 10.1093/genetics/104.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Langley C. H., Montgomery E., Hudson R., Kaplan N., Charlesworth B. On the role of unequal exchange in the containment of transposable element copy number. Genet Res. 1988 Dec;52(3):223–235. doi: 10.1017/s0016672300027695. [DOI] [PubMed] [Google Scholar]
  18. Montgomery E. A., Langley C. H. Transposable Elements in Mendelian Populations. II. Distribution of Three COPIA-like Elements in a Natural Population of DROSOPHILA MELANOGASTER. Genetics. 1983 Jul;104(3):473–483. doi: 10.1093/genetics/104.3.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. O'Hare K., Rubin G. M. Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell. 1983 Aug;34(1):25–35. doi: 10.1016/0092-8674(83)90133-2. [DOI] [PubMed] [Google Scholar]
  20. Ohta T. A model of duplicative transposition and gene conversion for repetitive DNA families. Genetics. 1985 Jul;110(3):513–524. doi: 10.1093/genetics/110.3.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ohta T. Population genetics of transposable elements. IMA J Math Appl Med Biol. 1984;1(1):17–29. doi: 10.1093/imammb/1.1.17. [DOI] [PubMed] [Google Scholar]
  22. Preston C. R., Engels W. R. Spread of P transposable elements in inbred lines of Drosophila melanogaster. Prog Nucleic Acid Res Mol Biol. 1989;36:71–85. doi: 10.1016/s0079-6603(08)60162-2. [DOI] [PubMed] [Google Scholar]
  23. Saedler H., Nevers P. Transposition in plants: a molecular model. EMBO J. 1985 Mar;4(3):585–590. doi: 10.1002/j.1460-2075.1985.tb03670.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Simmons M. J., Raymond J. D., Boedigheimer M. J., Zunt J. R. The influence of nonautonomous P elements on hybrid dysgenesis in Drosophila melanogaster. Genetics. 1987 Dec;117(4):671–685. doi: 10.1093/genetics/117.4.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Slatkin M. Genetic differentiation of transposable elements under mutation and unbiased gene conversion. Genetics. 1985 May;110(1):145–158. doi: 10.1093/genetics/110.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Snyder M., Doolittle W. F. P elements in Drosophila: selection at many levels. Trends Genet. 1988 Jun;4(6):147–149. doi: 10.1016/0168-9525(88)90016-9. [DOI] [PubMed] [Google Scholar]
  27. Stacey S. N., Lansman R. A., Brock H. W., Grigliatti T. A. Distribution and conservation of mobile elements in the genus Drosophila. Mol Biol Evol. 1986 Nov;3(6):522–534. doi: 10.1093/oxfordjournals.molbev.a040413. [DOI] [PubMed] [Google Scholar]
  28. Varmus H. E. Form and function of retroviral proviruses. Science. 1982 May 21;216(4548):812–820. doi: 10.1126/science.6177038. [DOI] [PubMed] [Google Scholar]

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