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. 1991 Oct;129(2):423–441. doi: 10.1093/genetics/129.2.423

A Functional and Structural Analysis of the Sex Combs Reduced Locus of Drosophila Melanogaster

A M Pattatucci 1, D C Otteson 1, T C Kaufman 1
PMCID: PMC1204634  PMID: 1743486

Abstract

We have undertaken a developmental genetic analysis of the homeotic gene Sex combs reduced (Scr) of Drosophila melanogaster by examining embryonic and adult phenotypes of mutations affecting Scr gene function. Molecular mapping of Scr breakpoint lesions has defined a segment of >70 kb of DNA necessary for proper Scr gene function. This region is split by the fushi tarazu (ftz) gene, with lesions affecting embryonic Scr function molecularly mapping to the region proximal (5') to ftz and those exhibiting polyphasic semilethality predominantly mapping distal (3') to ftz. Gain-of-function mutations are associated with genomic rearrangements and map throughout the Scr locus. Our analysis has revealed that the Scr locus encompasses genetic elements that are responsible for functions in both the embryonic and larval to adult periods of development. From these studies, we conclude that Scr is a complex genetic locus with an extensive regulatory region that directs functions required for normal head and thoracic development in both the embryo and the adult and that the regulation of Scr during these two periods is distinct.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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