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. 2025 May 2;20(5):e0322515. doi: 10.1371/journal.pone.0322515

Latent classes of substance use and delinquency in a Swedish national sample of adolescents and associated risk factors

Clas Björklund 1,*, Fredrik Sivertsson 2, Jonas Landberg 1, Jonas Raninen 3,4, Peter Larm 1
Editor: Ayse Ulgen5
PMCID: PMC12047767  PMID: 40315216

Abstract

Background

Identifying underlying subgroups might be a way to examine the development of co-occurrent substance use and delinquency. The aim of this study was to identify latent classes of substance misuse and delinquency in adolescence and which general risk factors are associated with these classes.

Methods

Data of two waves from a national representative Swedish birth cohort was used that consisted of 4,013 randomly selected adolescents (Male = 1,798, Female = 2,201, Missing = 14) Latent class analysis was used to identify classes of substance misuse and delinquency at age 17/18 and. logistic regression analysis was used to assess risk factors at age 15/16.

Results

Identified classes were: “Low/abstainers” (74.80%, n = 2858, Male = 1191 Female = 1656, Missing = 11) which acted as reference, “Alcohol only” (22.21%, n = 849, Male = 420, Female = 426, Missing = 3), “Polydrug use and crime” (2.15%, n = 82, Male = 52, Female = 30) and “High crime” (0.84%, n = 32, Male = 30, Females = 2). Factors associated with belonging to any classes engaging in substance use and delinquency were lower parental support, supervision, peer problems, and higher conduct problems, sensation-seeking behavior, distrust in society, and truancy.

Conclusions

Most people did not engage in substance use or delinquency. When accounting for less frequent behaviors such as normative adolescent drinking and one-time events of crime and drug use, about 3% of the population engaged in co-occurring substance use and delinquency. Several different factors from several domains where related to belonging to a class that used substances and/or engaged in delinquency. There were indications that the most extensive users and offender displayed a wide variety of severe level risk factors, which could have implications for targeted interventions. Though, statistical power was a problem and future research should use larger samples or alternative methods.

Introduction

Substance use and delinquency constitute a burden for public health, since substance use is associated with premature death, infectious diseases and poorer mental health [1, 2], while being a victim of crime is associated with premature death and negative health conditions [3, 4]. Individuals who are involved with both drug use and criminal behavior are also at a risk of developing health issues related to a long-term antisocial lifestyle such as hepatitis, pancreatitis, and sexually transmitted diseases [5]. Both behaviors are common. It is estimated that there are 1320.8 alcohol use disorders per 100 000 people and between 52.1 to 289.7 various drug use disorders per 100 000 people globally [1]. Also, interpersonal violence is the fifth leading cause globally for injuries [6]. It has also been reported that a fifth of the population in Sweden has been the victim of a crime [7].

Substance use and crime tend to co-occur in an individual. It is estimated that a quarter of incarcerated prisoners meet the criteria for alcohol use disorder and close to a third of prisoners meet the criteria for some type of drug use disorder [8]. Also, the prevalence of substance use disorders among individuals released on parole or on probationary sentencing are estimated to up to nine times higher than in individuals who have not had any contact with the criminal justice system [9].

Co-occurring substance use and delinquency might be more serious compared to only substance use and delinquency on their own. Co-occurrence of both behaviors is associated with worse mental and somatic health outcomes, as well as higher risk of recurrent substance misuse and reconviction, as compared to single behaviors [10]. Drug use can also contribute to an escalation of criminal activity and frequency of crime is higher during periods when use is also high. Substance use can also prolong the trajectory of criminal behaviors. Substance users seem to take a longer time to phase out of criminal activities than non-users [1113]. Thus, it is important to study the different ways in which substance use and delinquency tend to develop into co-occurring behaviors.

The association between substance use and crime has been explained by pharmacological effects that substances have on executive functions, increasing the risk of violence and other crime [14, 15]; that individuals commit crimes to finance addiction [15, 16]; that criminals engage in subcultures where substance use is promoted [12,17]; or that substance use and delinquency develop from similar risk factors [18].

From a developmental perspective, it seems that adolescence is a key period. This is the life-stage where both substance use and delinquency often have their onset, progress and peak through [19, 20]. It is also common that adolescents tend to engage in multiple types of risk behaviors and this might be considered a normative part of adolescence [21]. It is estimated that about 11% of Swedish 18-year-olds fulfil the criteria for substance use disorder and a considerable part are at risk of fulfilling criteria for such a disorder [22]. Also, it is estimated among Swedish adolescents that by age 19 almost a fifth of males and 5% of females have been registered at least once for a criminal act [20]. Thus, it seems that adolescence is a period where one is susceptible to the risk of developing substance use and delinquent behaviors. Common risk factors in adolescence are familial problems and negative parenting styles [2325], antisocial peers, and peer pressure [17,18,23,25], mental health problems such as hyperactivity, conduct problems and having symptoms of conduct disorder [2529] and problematic personality traits like impulsivity, sensation seeking and psychopathic personality traits [2730]. Though there is knowledge on adolescent risk factors for substance use and delinquency, there is less knowledge about the patterns and mechanisms through which substance use and delinquency tend to combine into co-occurring behaviors in this stage of life. One approach to explore such processes is to find underlying subgroups of patterns of substance use and delinquency and which factors are associated with these patterns.

Many studies have identified latent classes of substance users. Tomczyk and colleagues [31] suggest in their literature review that common latent classes among adolescents include the largest class with low or no use of substances, a class using only one type of substance, usually alcohol, and a polysubstance class, using at least two psychoactive substances.

Latent classes of delinquent and criminal behaviors among adolescents indicate that most fall into a class of “low or no criminal behavior” and do not engage in delinquency to a high degree. Among those adolescents that do engage in delinquency a “low involvement in crime” class that generally refrains from violent crime, and a class of “high frequency and high diversity of crimes” has been identified [3234].

For the development of co-occurring substance use and delinquency, classes of both substance use and delinquency are essential. However, only a few studies have taken this approach. One study on American violent offenders aged 12–25, found that almost 40% had indications of different types of substance use disorders, a larger group of alcohol and marijuana use disorders and a smaller for polysubstance use disorder [35]. Another study examined different classes of Swedes born between 1950–1993 registered for drug use by using the Swedish medical and crime registers. Two classes who engaged in criminal behavior, one larger with low frequency of drug use and one smaller with high frequency of drug use, and two classes who only engaged in drug use, one larger with lower frequency and one smaller with higher frequency, were identified [36]. Other studies have also identified classes of substance use and delinquency among risk populations such as inhalant users [37] or youths involved in diversion programs [17]. Since these studies are examining risk populations, it is not clear how these results translate to general population of adolescents. One study identified three latent classes among 548 adolescents aged 12–17 years recruited from two schools in Australia, where the most adapted class engaged in underage alcohol use only, whereas two other classes that were more heavily engaged in delinquency also used illicit drugs [38]. This study used dichotomized items (yes/no), neglecting frequency of behaviors. Consequently, knowledge of subgroups that engage in both substance use and delinquency is scarce, particularly as derived from large national representative samples.

Thus, the aim of the present study was to identify latent classes of substance use and delinquency in a national representative Swedish sample and to identify general developmental risk factors for the latent classes. Research questions included: (1) Which latent classes of substance use and delinquency can be identified in adolescence? (2) Which developmental risk factors are associated with each latent class in adolescence?

Materials and methods

Participants and procedure

Data from a longitudinal national birth cohort, known as Futura01, was used. In 2017 (T1), 500 Swedish schools were selected randomly, 343 of which agreed to participate (68.6%). Students in 9th grade (15–16 years) and born in 2001 were targeted, with one class per school randomly selected. Of 6,777 eligible students, 5,549 (81.9%) agreed to sign a written informed consent and to fill out a self-administered paper-and-pen questionnaire during school hours (between March and May). As reported elsewhere, the schools that participated did not differ regarding parental education, immigrant background or average grades compared to schools that did not participate [39]. Consent was only collected from the participants themselves and not from parents or legal guardians. According to the Swedish Act (2003:460) concerning the ethical review of research involving humans, individuals by the age of 15 are legally allowed to consent to participate in research without informing parents or legal guardians [40]. In 2019, when the participants were 17–18 years old, a web-based follow-up (T2) was administered (between March and June) and 4,013 (Male = 1,798, Female = 2,201, Missing information about sex = 14) responded (response rate of 72.3% of those that responded at baseline) and was included in the sample. Participants at T2 differed slightly from those at baseline, e.g., higher proportion of girls, higher sensation-seeking, aggressivity, and lesser alcohol consumption [41]. The project has been approved by the Ethical Review Board in Stockholm (Dnr 2017/103–31/5).

Measurements

Outcomes.

The outcomes of substance use and delinquency were from T2. All variables have been measured with self-report. Substance use consisted of alcohol, cannabis, and other drugs. Alcohol was measured with three items targeting consumption from the Alcohol Use Disorder Identification Test (AUDIT-C) which gives a score of 0–12, (α=0.76) [42]. Illicit drugs were measured via a battery of questions. The item used for different drugs was “How many times, during the latest 12 months, have you used any of the following?”. Drugs that were included were ‘marijuana’, ‘hashish’, ‘cocaine’, ‘spice/similar smoking substances’, ‘amphetamines’, ‘LSD/other hallucinogens’, and ‘other narcotics’. There was seven response alternatives which ranged from ‘0 times’ (score = 0) to ‘40+ times’ (score = 6). Illicit drugs were categorized into cannabis and other drugs. Cannabis contained marijuana and hashish (total score = 0–12, α=0.81, two items). Other drugs included the use of the other narcotics listed (total score: 0–30, α=0.77, five items). Delinquency was measured with questions targeting seven types of crime within the last twelve months, as developed by the Swedish National Council for Crime Prevention [43]. Four response alternatives varied from never (score = 0) to 5 + times (score = 3) for each type of crime. Delinquency was categorized into violent crime which included assault and illegally carrying a weapon (total score = 0–6, α=0.48), theft which included burglary, shoplifting and bike theft (total score = 0–9, α=0.48) and property crime which included vandalism and arson (total score = 0–6, α=0,56).

Risk factors.

Risk factors were from T1 and categorized into the domains of (1) Family factors, (2) Mental health problems, (3) Personality traits, (4) Peer factors, and (5) Other factors. Family factors contained parental support, parental supervision and parental rules measured by two items each. Parental support targeted how often the participant received warmth and support from their parents (α=0.89). Parental rules targeted how often parents set rules for the participant (α=0.75). Parental supervision targeted whether the parents knew where the participant was and with whom (α=0.76). Each item had five response alternatives that ranged from ‘almost always’ (score = 0) to ‘almost never’ (score = 4). These items were reversed in coding (total score: 0–8, example item: “My parents know where I am during evenings”). ‘Mental health problems’ were measured using five-items subscales from the Strength and Difficulties Questionnaire (SDQ) [44], with three response alternatives for each item ranging from ‘not true’ (score = 0) to ‘certainly true’ (score = 2, total score: 0–10). These subscales included emotional problems (α=0.70, example item: I worry a lot), conduct problems (α=0.51, example item: I am often accused of lying and cheating), and hyperactivity (α=0.70, example item: I am easily distracted). Personality traits included impulsivity, which was measured by five items from the Brief Barrat Impulsivity Scale (BIS-Brief) [45], with five response alternatives for each item ranging from ‘strongly disagree’ (score = 0) to ‘strongly agree’ (score = 4) (total score: 0–20, example item: “I easily get angry”, α=0.73); sensation seeking, which was measured with six items from the Brief Sensation Seeking Scale (BSSS) [46], with five response alternatives for each item ranging from ‘strongly disagree’ (score = 0) to ‘strongly agree’ (score = 4) (total score: 0–24, example item: “I sometimes take risks because it is fun”, α=0.88); and callous-unemotional traits, which were measured with three items from the Inventory of Callous-Unemotional Traits (ICU) [47], with three response alternatives for each item ranging from ‘not at all true’ (score = 0) to ‘definitely true’ (score = 3). Originally, this variable contained four items, but inter-item correlation showed one of the items to be uncorrelated with the others. This item was excluded, leaving three items. (total score: 0–9, α=0.52, example item: “I care about how others feel” (reverse item)). Since Cronbach’s alpha was considered low for this factor, the mean inter-item correlation was also checked. This value was 0.27 and was within acceptable ranges [48]. ‘Peer factors’ included peer problems, which was measured by a five-item subscale of the SDQ (total score: 0–10, example item: “I am often by myself. I often do things alone”, α=0.56) and being the perpetrator of bullying, which was measured by one item with a no/yes response. ‘Other factors’ included distrust in society, which consisted of five items targeting trust in various instances of society such as government and parliament, media, and researchers and experts, with four response alternatives varying from ‘very high trust’ (score = 0) to ‘no trust’ (score = 3) (total score: 0–15, α=0.76, example item: “How high is your trust in the judicial system?”,). Truancy was measured by one item – whether the respondent had been truant from school – with six response alternatives varying from ‘never’ to ‘several times per week’. Truancy was dichotomized into ‘no/yes’.

Analysis

Latent Class Analysis (LCA) was conducted in Stata 18 [49] to identify different subgroups of substance use and delinquency at T2. The z-scores for violent crime, property crime, theft, alcohol, cannabis and other drugs were entered as indicator variables. Missing values were deleted listwise. The highest missing value was for other drugs (4.23%, n = 170). The best model fit (number of classes) was determined by Akaike’s information criterion (AIC) and Bayesian information criterion (BIC), where smaller values indicate better model fit [50]. In addition to these, log-likelihood was also examined where higher values indicate a better fit. Also, considering previous literature, smaller classes who engaged in substance use/delinquency were expected. Though, there was no official cutoff for how small classes could be. A correlation matrix (Supplemental material online) was created to check for correlations among indicators. Some have suggested that correlations greater than 0.5 among indicators might create statistical problems with multicollinearity that can lead to emergence of spurious classes [50].

To see what factors at T1 predicted classes at T2, pairwise logistic regression analysis was used. For selecting variables for the regression-model, ANOVA was used (chi-square for categorical variables) to identify significant differences between latent classes. These steps of the analysis were performed in IBM SPSS 28 [51] Logistic regression analyses, where factors with the highest p-value were removed stepwise until only significant factors remained, where then conducted. This was to remove insignificant predictors and reduce the number of predictors to minimize risk of potentially overfitting the model. Biological sex was controlled for in every step of the analyses.

Results

Correlation was checked among the indicator variables before the analysis to check for multicollinearity. The highest was between theft and property crime (r = 0.60, p < 0.05) followed by cannabis and other drugs (r = 0.58, p < 0.05) which both exceeded 0.5. However, these indicators were deemed theoretically important and in line with the objective of the study and therefore included. The best latent class structure at T2 was identified based on model fit indices (AIC and BIC) which are shown in Table 1. A four-class solution best fitted the data.

Table 1. Goodness of fit – measures of number of latent classes.

No. of classes AIC BIC Log likelihood
1 64637.05 64712.03 -32306.53
2 57386.34 57505.06 -28674.17
3 53764.12 53926.57 -26865.06
4 52171.21 52377.40 -26052.60
5 52983.06 53226.74 -26452.53

Note: The chosen class solution is in bold.

A description of the classes as marginal means of z-scores and also raw means is shown in Table 2. The largest class, which comprised 74.80% of the sample (n = 2858, Male = 1191, Female = 1656, Missing = 11), had the lowest scores on all outcomes and was named “Low/abstainers”. This class was also selected as a reference group for the regression analyses as this was the class with the lowest amount of substance use and delinquency of all classes. The second largest class that emerged, which was 22.21% of the sample (n = 849, Male = 420 Female = 426, Missing = 3), was named “Alcohol only” with the highest alcohol use of all classes, but lower scores on everything else than other classes except for “Low/abstainers”. The third largest class identified, which consisted of 2.15% (n = 82, Male = 52, Female = 30), was named “Polydrug use and crime” and scored in comparison to other classes high on alcohol, the highest on cannabis and other drugs, and the second highest on all crime types. The smallest identified class, which was 0.84% (n = 32, Male = 30, Female = 2), was named “High crime” which scored the highest on all crime types, the third highest on alcohol and the second highest on cannabis and other drugs. For visual representation see Fig 1.

Table 2. Parameter estimates including marginal means of z-scores/raw means for latent classes.

Z-score/raw means Low/
abstainers
Alcohol only Polydrug use and crime High crime Wald test
74.80%
(n = 2858)
22.21%
(n = 849)
2.15%
(n = 82)
0.84%
(n = 32)
Violent crime -0.10/0.10 0.28/0.23 0.85/0.88 2.78/2.66 846.20
Theft -0.19/0.07 0.21/0.41 1.29/1.16 5.71/4.38 2070.64
Property crime -0.15/0.01 0.07/0.11 0.72/0.35 8.34/3.31 6016.53
Alcohol -0.50/0.82 1.28/4.72 1.20/4.35 1.00/3.94 5371.43
Cannabis -0.22/0.03 0.08/0.50 5.62/8.48 0.86/1.59 8693.89
Other drugs -0.12/0.01 -0.05/0.08 3.69/3.71 2.35/2.41 1927.72

Note. all Wald tests were significant at p < 0.05

Fig 1. Line chart of z-scores of estimator variables grouped by latent classes.

Fig 1

Risk factor scores (means and percentages) at T1 for latent classes are shown in Table 3, with post-hoc differences from the Low/abstainers class identified by ANOVA and Chi-square tests. In general, the risk factor profiles of “Alcohol only”, “Polydrug use and crime” and “High crime” differed from “Low/abstainers”, with less favorable scores (i.e., lower scores on protective factors within “Family factors” and higher on risk factors within the other domains), except for emotional problems where only the “High crime” class had lower scores. Parental rules did not differ significantly from “Low/abstainers” among any of the groups and was excluded from the regression analysis for all classes.

Table 3. Risk factor profiles of latent classes presented as mean levels or percentages.

Low/
abstainers
(n = 2858)
Alcohol only
(n = 849)
Polydrug use and crime
(n = 82)
High crime
(n = 32)
F value/Chi-square value
Family factors
Parental rules 4.12 4.20 3.77 3.92 0.86
Parental supervision 7.20 6.57 5.76 5.44 66.51
Parental support 6.99 6.85 5.84 5.68 16.13
Mental health problems
Hyperactivity 3.59 4.40 4.90 4.77 32.90
Conduct problems 1.40 1.95 2.47 3.20 50.74
Emotional problems 3.50 3.44 3.51 2.31 2.77
Personality traits
Impulsivity 7.25 8.94 10.65 8.90 50.60
Callous-unemotional traits 1.50 1.95 2.79 3.06 46.48
Sensation seeking behavior 9.04 12.75 16.68 13.64 127.64
Peer factors
Peer problems 2.23 1.79 2.00 2.04 16.02
Bullying others (% yes) 2.50 6.1 15.70 6.70 51.22
Other factors
Truancy (% yes) 20.6 33.0 61.7 31.3 118.56
Distrust in society 5.55 6.22 6.58 7.72 18.52

Note: Bold = significant differences (p < .05) from low/abstainers by ANOVA post hoc (means) and Chi-square test (percentage).

Significant risk factors in Table 3 were included in pairwise multiple logistic regression analyses with “Low/abstainers” as the reference group, in order to identify which risk factors are uniquely associated with latent classes at T2. Non-significant factors were removed stepwise from the analysis until only significant risk factors remained for each class. The excluded factors after ANOVA tests and regression analyses were; parental rules, emotional problems, impulsivity, callous unemotional traits and bullying others for all classes; parental supervision for “High crime”; parental support for “Alcohol only”; hyperactivity for “Polydrug use and crime” and “High Crime; conduct problems for “Polydrug use and crime; sensation seeking behavior for “High crime”; peer problems for “Polydrug use and crime” and “High crime”; truancy for “Alcohol only” and “High crime”; and distrust in society for “Alcohol only” and “Polydrug use and crime”. For belonging to the “Alcohol only” class, higher parental supervision and peer problems were associated with decreased probability, whereas higher sensation seeking behavior, conduct problems and hyperactivity were associated with increased probability. For belonging to the “Polydrug use and crime” class, higher parental support and parental supervision decreased the probability, whereas higher sensation seeking behavior and truancy increased the probability. For belonging to the “High crime” class, higher parental support decreased the probability, whereas higher conduct problems and distrust in society increased the probability. (see Table 4.).

Table 4. Associations between risk factors at T1 and latent classes at T2 calculated with multiple logistic regression analyses, providing Odds Ratios (OR) with 95% confidence intervals in brackets.

Alcohol Only (n = 849) Polydrug use and crime (n = 82) High crime (n = 32)
Family factors
Parental supervision 0.88 (0.83-0.93) 0.87 (0.78-0.98)
Parental support 0.87 (0.78-0.96) 0.80 (0.68-0.94)
Mental health problems
Hyperactivity 1.05 (1.01-1.09)
Conduct problems 1.08 (1.01-1.15) 1.50 (1.23-1.82)
Personality traits
Sensation seeking behavior 1.08 (1.07- 1.10) 1.23 (1.16-1.29)
Peer factors
Peer problems 0.82 (0.77-0.87)
Other factors
Truancy 2.83 (1.71-4.68)
Distrust in society 1.15 (1.02-1.31)

Note: Bold = sig. p < .05, Low/Abstainers at T2 acted as the reference group in all analyses. Biological sex was controlled for in all analyses. For each latent class, the risk factor with the highest p-value was removed stepwise from the analysis until only significant risk factors remained.

Discussion

The aim of the present study was to identify latent classes of substance use and delinquency in adolescence and to identify risk factors for each class. Four latent classes were identified.

Firstly, the largest class was “Low/abstainers” who participated in very little or almost no substance use and delinquency. This in line with previous research, as most people in the general population do not engage in any form of problematic substance use or criminal activity [31, 32]

Secondly, three classes engaging in substance use and/or delinquency were identified. Almost a quarter were classified into the “Alcohol only” class, where members displayed the highest alcohol consumption of all classes. This is also a commonly identified latent class [30]. Adolescence is the period where drinking, especially binge drinking, most often escalates and peaks. Among Swedish 18-year-olds it is estimated that almost a quarter has displayed either harmful use, alcohol dependence or sub-threshold for alcohol dependence [22]. It is likely that the “Alcohol only” class identified in this study consists of adolescents with similar drinking behavior. It still not clear, however, which of these adolescent’s drinking is constrained to the adolescent years and whose is continued into adult years. This class also did not engage in any extensive delinquency despite having the highest alcohol consumption. This is notable since alcohol has been previously implied to be a contributing factor to criminal behavior, especially aggression and violence [14]. However, some research imply that alcohol use does not cause this behavior in itself, but rather directs it onto things such as provoking or inhibitory cues [52]. Also, it has been implied that the most frequent and persistent criminal offenders are driven by different familial and pathological factors early on in life, such as family problems, mental health issues and problematic personality [53]. It may be that there are other factors which are more driving in delinquency than only alcohol consumption. This could be possible, since judging by the mean scores of risk factors among the classes that engaged in substance use and/or delinquency, the “Alcohol only” class seemed to be the most well-adjusted. Though, it should be noted that this is not something that has been tested in this study and therefore remains speculative.

Further, a “Polydrug use and crime” class was identified with co-occurrence of multiple substances, both alcohol, cannabis and other drugs, and acts of delinquency. This class had high alcohol consumption, though they were still consuming less than “Alcohol only”. This class also had the highest illicit drug use compared to the other classes, particularly cannabis. This class was also more likely to engage in delinquency than both the “Low/Abstainers” class and the “Alcohol only” class. Though this difference was not as large as between the “High crime” class and the other classes. Although previous studies have identified a polysubstance use group that tends to be smaller in numbers than those that only engage in one type of substance [30], the present study extends these findings by demonstrating that this group of polysubstance using adolescents also commit crime, but to a smaller extent as their level of delinquent acts was not as high as the “High crime” class.

Moreover, a “High crime” class was identified who scored the highest on all crime types, considerably higher for every crime type compared to “Polydrug use and crime” who was the second highest for crime among the classes. This class also engaged in co-occurring behaviors, namely consuming alcohol, illicit drugs and committing crimes. The alcohol consumption of the “High crime” class was also considerably higher than for the “Low/abstainers” class. Also, this class had the second highest illicit drug use. In the general population, the number of individuals who display a pattern of high frequent delinquent behaviors is often smaller [32]. It has also been established that a small group of individuals commit a disproportionate number of crimes in the general population. An example of this phenomenon is that 68% of violent crimes in Sweden can be attributed to 1% of the population [54]. Another example of this is that of the life course persistent offender in Moffit’s taxonomy. A group of offenders that is very small in size, but commit a disproportionately high frequency of criminal offences and also begin their offending in early adolescence and childhood [53]. This can correspond to the “High crime” class that was identified in this study – a very small group that committed the highest amount of crime. Though in this stage it is not clear how the further criminal behavior of this class will develop. In Moffit’s taxonomy the life course persistent offender differs from the adolescent limited offender who ceases their offending in adulthood. Some delinquent behavior during adolescence can be considered normative and the majority of these phase out in the years to follow [20,53]. It is not possible to discern in this study which members of “High crime” class will cease their delinquency and who will retain it into adulthood. It could be that some of the members of this class will go on to develop a pattern of offending close to that of the life course persistent offender, but this is at this stage speculative.

Thirdly, although the classes of “High crime” and “Polydrug use and crime” displayed co-occurring behaviors, further solidifying the co-occurring nature of substance misuse and delinquency, their group sizes are small. This implies that when less frequent behaviors are not accounted for, i.e., occasional and one-time events of substance use or delinquency, only about 3% of the sample engaged in co-occurring substance use and delinquency. One interpretation of this finding can be that engagement in multiple risk behaviors during adolescence is perhaps less common than we think, when minor engagements are excluded.

Regarding associations with risk factors at T1. Risk factors were most salient for the “Alcohol only” class with 849 participants, where higher parental supervision and peer problems decreased the probability of belonging to this class, as compared to the “Low/abstainers” class. Lack of parental supervision has previously been established as a significant risk factor for problematic alcohol consumption among adolescents [23]. Considering peer problems, this measures social isolation and expulsion from friend groups of the same age. Peer influence is a strong risk factor for alcohol use and socializing with others who use alcohol increase the risk of consumption [17,18,23]. Thus, it is likely that less socializing with others decreased the probability. This does not necessarily mean that socializing with peers is something maladaptive. Although high alcohol consumption is associated with a number of health issues [1], not all adolescent drinkers retain their consumption into adulthood [55]. For some, temporary rule-breaking behavior along with peers can be considered a normative part of adolescence [20,55]. It seems that this pattern also can apply to alcohol use and after adolescence when peer influence is not as salient, the alcohol consumption will decrease among some members of the “Alcohol only” class. Hyperactivity, conduct problems and sensation seeking also increased the probability of belonging to the “Alcohol only” class, factors that have previously been associated with adolescent alcohol use [26]. Further, parental supervision and support decreased the probability of being classified into the “Polydrug use and crime” class whereas sensation seeking behavior and truancy increased the probability, factors that previously been associated with illicit drug abuse among adolescents [27,29]. In a similar matter, parental support decreased the probability of being classified into the “High crime” class whereas conduct problems increased the probability, where negative parental strategies and conduct problems, have previously been established to be related to delinquent behaviors [24,28]

When interpretating the results, consideration needs to be taken to the small group sizes of the “High crime” class and the “Polydrug use and crime” class that consisted of 32 and 82 individuals respectively, substantially limiting the statistical power. For example, the “High crime” class had considerable higher mean scores of sensation seeking behavior than the “Low/abstainers” class and the highest mean score of callous-unemotional traits, but neither of these risk factors remained significant, after the process of eliminating non-significant factors stepwise in the analytical approach. Thus, it is likely that factors that have previously been associated with criminal activity and substance use, such as callousness, impulsivity and sensation seeking behavior [2529], did not reach significance in this study due to the lack of statistical power. Thus, these findings should be interpreted cautiously. Nevertheless, the risk factors that were significant in this study for the “High crime” and “Polydrug use and crime” classes, might be particularly salient due to the fact that they remained significant despite the apparent problem with lack of statistical power and low prevalence of drug use and delinquency in the sample.

Perhaps, the key to understand the “Polydrug use and crime” and “High crime” classes is similarities in risk profiles when it comes to severity. “High crime” and “Polydrug use and crime” members showed higher means and appears more maladjusted than “Alcohol only”. For instance, the factors that predicted both “Alcohol only”, “Polydrug use and crime” and/or “High crime” (parental supervision, sensation seeking behavior and conduct problems) had stronger association (weaker for parental supervision) to the latter groups. The latter groups also had higher levels of these risks than “Alcohol only”. “Polydrug use and crime” and “High crime” also consistently had higher level of risk among all factors that reached significance for “Alcohol only”, but not for the aforementioned classes. It has been emphasized previously that the most serious antisocial individual, such as the life course persistent offender in Moffit’s taxonomy, display both problematic individual and familial factors [53]. Factors that both “Polydrug use and crime” and “High crime” displayed high levels of. Risk factors also have a cumulative effect, where more factors present leads to a higher risk of an outcome [56]. The “Polydrug use and crime” and “High crime” classes could possibly also have a wider range of different risk factors present, leading to problematic behaviors. In order to examine if risk factor severity and accumulation contributes to these more maladapted classes, a larger sample is required.

Implications

There are some implications with these results. Firstly, since there are indications that extensive substance use and delinquency seems to be limited to small part of the general population and most are not in need of any interventional actions. Interventions may be located and focused to where they are most needed instead. Though, this should be done with caution as targeted interventions may run the risk of labeling and stigmatizing individuals. Secondly, this study and research before indicate that the risk factor profile of the most severe substance users and delinquent offenders is multifactorial. The most extensive users and offenders have a high level and wide range of several different risk factors. It may be that interventions also need to be multifactorial and cover several different problem areas, such as improving mental health, family conditions, peer relations and school environment etc., in order to diminish and prevent further substance use and delinquent behaviors in the future.

Strengths and Limitations

There are a number of strengths and limitations with this study. The major strength is the use of a randomly selected and nationally representative sample.

There are a number of limitations. The first one is the apparent lack of statistical power due to classes that displayed any extensive substance use and delinquency being very small, which might have had effects on the results, increasing type II errors. It could also be that participants that display very high degrees of substance misuse and delinquency could not be reached due to being incarcerated in juvenile correctional facilities, or rehabilitation centers, and thus were not included in this study. Hence, the results of this study might be biased towards those who do not engage in substance use or delinquency. Due to the low prevalence and how “other drugs” was measured, a further limitation was that it was not possible to make any comparison between different kind of substances (e.g., comparing sedatives to stimulants etc.) and how they co-occur and relate with delinquency. Another limitation refers to the use of self-report which relies on the recall of participants. There is also the risk of both under- and overreporting of crimes committed and substances consumed which might affect the reliability. Another limitation is that a relatively short time window has been investigated. The data only stretches for roughly two years between the ages of 15/16–17/18. It is possible that some risk factors may have been present in earlier stages of life which might be relevant from a developmental perspective, but also that latent class characteristics were present before risk factors. Also, there is no information beyond the age of 17/18, which may be relevant for understanding of further development.

With the inability to detect significant risk factors due to low prevalence of substance use and delinquency in the sample and limited statistical power, future studies should consider larger samples to reduce this problem. Another strategy for future research is to employ official registers such as medical records and crime registries. Since this study was biased towards those who did not engage in substance use and/or delinquency, official records could be possible way for studies with similar design to reach participants who could not be reached otherwise. Future studies might also want to consider comparing different types of substances and how they relate to and co-occur with delinquency. Also, longer time windows should be investigated which enables to examines developmental trajectories and differences between those whose substance use and delinquency is limited to adolescent years and those persist into later years.

Conclusion

This study sought to identify different latent classes of substance misuse and delinquency in adolescence, and developmental risk factors associated with them. The vast majority of the participants do not engage in any extensive substance misuse or delinquency. The most common form of substance use was alcohol, likely adolescent binge drinking, and the most extensive drug use and delinquency were attributed about 3% of the sample. Substance users and delinquent offenders also show a multifactorial risk profile where several factors, such as familial problems, mental health issues, personality traits, peer factors and other factors are related to belonging to a class with substance use and/or committing delinquency. This has implications that interventions might need to cover several factors as well. A relatively short time window has been investigated and future research should investigate longer time frames to establish prevalence of which limit their consumption/delinquency to adolescence and which persist into adult years. Statistical power was also a problem in this study and future research should use larger samples or other methods in an attempt to improve this.

Supporting information

S1 Table. Correlation matrix of indicator variables.

(DOCX)

pone.0322515.s001.docx (13.9KB, docx)

Acknowledgments

The authors of this study have no specific acknowledgements to make.

Data Availability

The data for this study are managed by Karolinska Institutet. The Futura01 survey include sensitive information on individuals, as defined by the Swedish Personal Data Act (Personuppgiftslagen, PUL, SFS 1998:204; § 13). Restrictions apply to the availability of these data, which were used under license for this study. Data are available from registrator@ki.se given approval from the Swedish Ethical Review Authority (registrator@etikprovning.se). Access to the data for the purpose of this study was based on membership of a research team with ethical approval for analyses of data from Futura01. Researchers who qualify by getting ethical approval from Swedish authorities can request access to data from the data holder. Data is stored according to the Archives Act (1990:782) and the regulations and general recommendations of the Swedish National Archives concerning the disposal of documents in research activities conducted by government agencies (RA-FS 1999:1).

Funding Statement

The author(s) received no specific funding for this work.

References

  • 1.GBD 2016 Alcohol and Drug Use Collaborators. The global burden of disease attributable to alcohol and drug use in 195 countries and territories: A systematic analysis for the Global Burden of Disease 2016. Lancet Psychiatry. 2018;5(12);987–1012. doi: 10.1016/S2215-0366(18)30337-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.McKetin R, Leung J, Stockings E, Huo Y, Foulds J, Lappin JM, et al. Mental health outcomes associated with the use of amphetamines: A systematic review and meta-analysis. EClinicalMedicine. 2019;16:81–97. doi: 10.1016/j.eclinm.2019.09.014 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Björklund K, Häkkänen-Nyholm H, Huttunen T, Kunttu K. Violence victimization among Finnish university studies: Prevalence, symptoms and healthcare usage. Soc Sci Med. 2010;70(9);1415-22. doi: 10.1016/j.socscimed.2009.12.015 [DOI] [PubMed] [Google Scholar]
  • 4.Pridemore W A, Berg M T. What is past prologue: A population-based case-control study of repeat victimization, premature mortality, and homicide. Aggress Behav. 2017;43(2):176–89. doi: 10.1002/ab.21673 [DOI] [PubMed] [Google Scholar]
  • 5.Vaughn MG, Salas-Wright CP, Delisi M, Piquero AR. Health associations of drug-involved and criminal-justice-involved adults in the United States. CJB. 2014;41(3):318–36. doi: 10.1177/0093854813504405 [DOI] [Google Scholar]
  • 6.GDB 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1204–22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Brottsförebyggande rådet: Nationella trygghetsundersökningen: Om utsatthet, trygghet och förtroende [Internet]. Stockholm: Brottsförebyggande rådet; 2024. [Cited 2025 15 Jan]. Available from: https://bra.se/download/18.403f39de192bd4311312c81/1730114738563/2024_8_Nationella-trygghetsundersokningen-2024.pdf [Google Scholar]
  • 8.Fazel S, Yoon IA, Hayes AJ. Substance use disorders in prisoners: an updated systematic review and meta-regression analysis in recently incarcerated men and women. Addiction. 2017;112(10):1725–39. doi: 10.1111/add.13877 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Fearn NE, Vaughn MG, Nelson EJ, Salas-Wright CP, DeLisi M, Qian Z. Trends and correlates of substance use disorders among probationers and parolees in the United States 2002–2014. Drug Alcohol Depend. 2016;167:128–39. doi: 10.1016/j.drugalcdep.2016.08.003 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Larm P, Silva TC, Hodgins S. Adolescent substance misusers with and without delinquency: Death, mental and physical disorders, and criminal convictions from age 21. J Subst Abuse Treat. 2015;59:1–9. doi: 10.1016/j.jsat.2015.06.009 [DOI] [PubMed] [Google Scholar]
  • 11.McKetin R, Boden JM, Foulds JA, Najman JM, Ali R, Degenhardt L, et al. The contribution of methamphetamine use to crime: Evidence from Australian longitudinal data. Drug Alcohol Depend. 2020;216:108262. doi: 10.1016/j.drugalcdep.2020.108262 [DOI] [PubMed] [Google Scholar]
  • 12.Welte JW, Barnes GM, Hoffman JH, Wieczorek WF, Zhang L. Substance involvement and the trajectory of criminal offending in young males. Am J Drug Alcohol Abuse. 2005;31(2);67–284. doi: 10.1081/ADA-200047934 [DOI] [PubMed] [Google Scholar]
  • 13.Green KM, Doherty EE, Ensminger ME. What’s drugs got to do with it? Examining the relationship between drug onset and duration with criminal outcomes in an African American cohort. Addict Behav. 2020;110;1–6. doi: 10.1016/j.addbeh.2020.106539 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Bushman BJ, Cooper HM. Effects of alcohol on human aggression: an integrative research review. Psychol Bull. 1990;107(3):341–54. doi: 10.1037/0033-2909.107.3.341 [DOI] [PubMed] [Google Scholar]
  • 15.Goldstein PJ. The drugs/violence nexus: A tripartite conceptual framework. J Drug Issues. 1985;15(4);493–506. doi: 10.1177/002204268501500406 [DOI] [Google Scholar]
  • 16.Reddon H, Fast D, DeBeck K, Werb D, Hayashi K, Wood E, et al. Prevalence and correlates of selling illicit cannabis among people who use drugs in Vancouver. Canada; A ten-year prospective cohort study. Int J Drug Policy. 2019;69:16–23. doi: 10.1016/j.drugpo.2019.02.006 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Dembo R, Willimas L, Wothke W, Schmeidler J. The relationships among family problems, friends’ troubled behavior, and high risk youths’ alcohol/other drug use and delinquent behavior: A longitudinal study. Int J Addict. 1994;29(11);1419–42. doi: 10.3109/10826089409048717 [DOI] [PubMed] [Google Scholar]
  • 18.Wade T, Pevalin D. Adolescent delinquency and health. Can J Criminol Crim Justice. 2005;47(4):619–54. doi: 10.3138/cjccj.47.4.619 [DOI] [Google Scholar]
  • 19.Ander B, Fransson E I, Bergnehr D, Gerdner A. Onset of substance use among early adolescents in Sweden. J Soc Work Pract. 2020;20(2):105–21. doi: 10.1080/1533256X.2020.1748973 [DOI] [Google Scholar]
  • 20.Carlsson C, Sivertsson F. Age, gender and crime in stockholm birth cohort to age 64. J Dev Life Course Criminol. 2021;7:359–84. https://10.1007/s40865-021-00172w. [Google Scholar]
  • 21.Willoughby T, Chalmers H, Busseri MA. Where is the syndrome? Examining co-occurrence among multiple problem behaviors in adolescence. J Consult Clin Psychol. 2004;72(6);1022-37. doi: 10.1037/0022-006X.72.6.1022 [DOI] [PubMed] [Google Scholar]
  • 22.Gerdner A, Håkansson A. Prevalence and comorbidity in a Swedish adolescent community sample – gambling, gaming, substance use, and other psychiatric disorders. BMC Psychiatry. 2022;22;594. doi: 10.1186/s12888-022-04218-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Prins SJ, Kajeepeta S, Pearce R, Beardslee J, Pardini D, Cerda M. Identifying sensitive periods when changes in parenting and peer factors are associated with changes in adolescent alcohol and marijuana use. Soc Psychiatry Psychiatr Epidemiol. 2020;56(4);605–17 doi: 10.1007/s00127-020-01955-0 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Chng GS, Chu CM, Zeng G, Li D, Ting MH. A latent class analysis of family characteristics linked to youth offending outcomes. J Res Crime Delinq. 2016;53(6);765–87. doi: 10.1177/0022427816644947 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Nawi AM, Ismail R, Ibrahim F, Hassan MR, Manaf MRA, Amit N, et al. Risk and protective factors of drug abuse among adolescents: a systematic review. BMC Public Health. 2021;21:2088. doi: 10.1186/s12889-021-11906-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Chartier KG, Hesselbrock MN, Hesselbrock VM. Development and vulnerability factors in adolescent alcohol use. Child Adolesc Psychiatr Clin N Am. 2010;19(3):493–504. doi: 10.1016/j.chc.2010.03.004 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Murray J, Shenderovich Y, Gardner F, Mikton C, Derzon J H, Liu J, et al. Risk factors for antisocial behavior in low- and middle-income countries: A systematic review of longitudinal studies. Crime Justice. 2018;47:255–364. doi: 10.1086/696590 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Morrow AS, Villodas MT, Cunius MK. Prospective risk and protective factors for juvenile arrest among youth at risk for maltreatment. Child Maltreat. 2019;24(3):286–98. doi: 10.1177/10775595198288 [DOI] [PubMed] [Google Scholar]
  • 29.Isaksson J, Sjöblom S, Schwab-Stone M, Stickley A, Ruchkin V. Risk factors associated with alcohol use in early adolescence among American Inner-City Youth: A longitudinal study. Subst Use Misuse. 2020;55(3);358–66. doi: 10.1080/108026084.20191671867 [DOI] [PubMed] [Google Scholar]
  • 30.Meehan AJ, Maughan BJ, Barker ED. Health and functional outcomes for shared and unique variances of interpersonal callousness and low prosocial behavior. J Psychopathol Behav Assess. 2019;41;353–65. doi: 10.1007/s10862-019-09756-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Tomczyk S, Isensee B, Hanewinkel R. Latent classes of polysubstance use among adolescents-a systematic review. Drug Alcohol Depend. 2016;12:12–29. doi: 10.1016/j.drugalcdep.2015.11.035 [DOI] [PubMed] [Google Scholar]
  • 32.Barnes JC, Boutwell BB, Morris RG, Armstrong TA. Explaining different patterns of self-reported delinquency. J Contemp Crim Justice. 2012;28(3):254–72. doi: 10.1177/1043986212450217 [DOI] [Google Scholar]
  • 33.Galinari LS, Bazon MR. Criminal behavior and psychosocial risk factors in brazilian adolescent offenders: An exploratory latent class analysis. Int J Environ Res Public Health. 2021;18(19):10509. doi: 10.3390/ijerph181910509 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Nasaescu E, Zych I, Ortega-Ruiz R, Farrington DP, Llorent VJ. Longitudinal patterns of antisocial behaviors in early adolescence: A latent class analysis and latent transition analysis. Eur J Psychol Appl Legal Context. 2020;12(2);85–92. [Google Scholar]
  • 35.DeLisi M, Vaughn MG, Salas-Wright CP, Jennings WG. Drugged and dangerous: Prevalence and variants of substance use comorbidity among seriously violent offenders in the United States. J Drug Issues. 2015;45(3):232–48. doi: 10.1177/0022042615579237 [DOI] [Google Scholar]
  • 36.Kendler KS, Ohlsson H, Sundquist K, Sundquist J. A latent class analysis of drug abuse in a national Swedish sample. Psychol Med. 2013;43(10):2169–78. doi: 10.1017/S0033291713000081 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Nakawaki B, Crano W. Patterns of substance use, delinquency, and risk factors among adolescent inhalant users. Subst Use Misuse. 2015;50(1):114–22. doi: 10.3109/10826084.2014.961611 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Hasking PA, Scheier LM, Abdallah AB. The three latent classes of adolescent delinquency and the risk factors for membership in each class. Aggress Behav. 2011;37(1):19–35. doi: 10.1002/ab.20365 [DOI] [PubMed] [Google Scholar]
  • 39.Ramstedt M, Raninen J, Larm P, Livingston M. Children with problem-drinking parents in a Swedish national sample: is the risk of harm related to the severity of parental drinking?. Eur J Public Health. 2023;33(2):312–6. doi: 10.1039/eurpub/ckad022 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.The Swedish Act concerning the ethical review of research involving humans (SFS 2003:460). Stockholm: The Ministry of Education and Cultural Affairs. [Google Scholar]
  • 41.Sjödin L, Raninen J, Larm P. Early drinking onset and subsequent alcohol use in late adolescence: A longitudinal study of drinking patterns. J Adolesc Health. 2024;74;1225–30. doi: 10.1016/j.adohealth.2024.02.014 [DOI] [PubMed] [Google Scholar]
  • 42.Bush K, Kivlahan DR, McDonnel MB, Fihn ST, Bradley KA. The audit alcohol consumption questions (AUDIT-C). Arch Intern Med. 1998;58:1789–95. [DOI] [PubMed] [Google Scholar]
  • 43.Brottsförebyggande rådet: Skolundersökning om brott 2019: Om utsatthet och delaktighet i brott [Internet]. Stockholm: Brottsförebyggande rådet; 2020. [Cited 2024 16 Aug]. Available from: https://www.bra.se/download/18.7d27ebd916ea64de5306dead/1606817015507/2020_11_Skolundersokningen_om_brott_2019.pdf [Google Scholar]
  • 44.Goodman R. Strengths and difficulties questionnaire: A research note. J Child Psychol Psychiat. 1997;38(5):581–6. [DOI] [PubMed] [Google Scholar]
  • 45.Steinberg L, Sharp C, Stanford MS, Sharp AT. New tricks for an old measure: The development of the barratt impulsiveness scale-brief (BIS-Brief). Psychol Assess. 2013;25(1);216–26. doi: 10.1037/a0030550 [DOI] [PubMed] [Google Scholar]
  • 46.Hoyle RH, Stephenson MT, Palmgreen P, Pugzles Porch E, Donohew RL. Reliability and validity of a brief measure of sensation seeking. Pers Individ Differ. 2002;32;401–14. [Google Scholar]
  • 47.Kimonis ER, Frick PJ, Skeem JL, Marsee MA, Cruise K, Munoz LC, et al. Assessing callous-unemotional traits in adolescent offenders: validation of the Inventory of Callous-Unemotional Traits. Int J Law Psychiatry. 2008;31(3):241–52. doi: 10.1016/j.ijlp.2008.04.002 [DOI] [PubMed] [Google Scholar]
  • 48.Clark LA, Watson D. Constructing validity: Basic issues in objective scale development. Psychol Assess. 1995;7(3):309–19. doi: 10.1037/1040-3590.7.3.309 [DOI] [Google Scholar]
  • 49.StataCorp. Stata Statistical Software. Version 18. College Station, TX: StataCorp LLC. 2023. [Google Scholar]
  • 50.Sinha P, Calfee C S, Delucci K L. Practitioner’s guide to latent class analysis: Methodological considerations and common pitfalls. Crit Care Med. 2021;49(1):63–79. doi: 10.1097/CCM.0000000000004710 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 51.IBM Corp. IBM SPSS Statistics for Windows. Version 28.0. Armonk, NY: IBM Corp. 2023. [Google Scholar]
  • 52.Giancola PR, Duke AA, Ritz KZ. Alcohol, violence, and the Alcohol Myopia Model: preliminary findings and implications for prevention. Addict Behav. 2011;36(11):1019–22. doi: 10.1016/j.addbeh.2011.05.00 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53.Moffitt TE. Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. 1993;100(4):674–701. doi: 10.1037//0033-295x.100.4.674 [DOI] [PubMed] [Google Scholar]
  • 54.Falk O, Wallinius M, Lundström S, Frisell T, Anckarsäter H, Kerekes N. The 1% of the population accountable for 63% of all violent crime convictions. Soc Psychiatry Psychiatr Epidemiol. 2014;49(4):559–71. doi: 10.1007/s00127-013-0783-y [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 55.Tucker JS, Ellickson PL, Orlando M, Martino SC, Klein DJ. Substance use trajectories from early adolescence to emerging adulthood: A comparison of smoking, binge drinking and marijuana use. J Drug Issues. 2005;35(2):307–22. doi: 10.1177/002204260503500205 [DOI] [Google Scholar]
  • 56.Anderberg M, Dahlberg M, Wennberg P. Criminality among young people substance use problems in Sweden: A one-year follow-up study. J Drug Issues. 2022:1–15. doi: 10.1177/0022042611046596 [DOI] [Google Scholar]

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PONE-D-24-39038Latent classes of substance use and criminal offending in a Swedish national sample of adolescents and associated risk factorsPLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Partly

Reviewer #3: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

Reviewer #3: No

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Overall comments. Big sample, suitable methodological choice for the aim, good to focus on SU and criminal offending in synergy, and an important research question (including current relevance). However, there are some issues regarding lack of information on the procedure, definition of groups and interpretation of results that need to be resolved before being able to decide on the study’s contribution to the field (i.e. above all information regarding methodology, see comments below). The language is ok (with minor exceptions).

See attached file for specific recommendations.

Reviewer #2: The current study has potential but suffers from some important problems, which fortunately can be rectified.

1. The engagement of the literature is weak which is problematic because there are latent class papers of the crime/substance use overlap. Several of these are listed below and were based on the NESARC, NSDUH, and other epidemiological data.

a. Vaughn, M. G., Salas-Wright, C. P., Delisi, M., & Piquero, A. R. (2014). Health associations of drug-involved and criminal-justice-involved adults in the United States. Criminal Justice and Behavior, 41(3), 318-336.

b. DeLisi, M., Vaughn, M. G., Salas-Wright, C. P., & Jennings, W. G. (2015). Drugged and dangerous: Prevalence and variants of substance use comorbidity among seriously violent offenders in the United States. Journal of Drug Issues, 45(3), 232-248.

c. Fearn, N. E., Vaughn, M. G., Nelson, E. J., Salas-Wright, C. P., DeLisi, M., & Qian, Z. (2016). Trends and correlates of substance use disorders among probationers and parolees in the United States 2002–2014. Drug and alcohol dependence, 167, 128-139.

d. Kendler, K. S., Ohlsson, H., Sundquist, K., & Sundquist, J. (2013). A latent class analysis of drug abuse in a national Swedish sample. Psychological Medicine, 43(10), 2169-2178.

2. The discussion largely reiterates the findings and again the engagement of the literature is weak. It seems the findings have implications for Moffitt’s developmental taxonomy.

a. Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychological Review, 100, 674-701.

b. Moffitt, T. E. (2018). Male antisocial behaviour in adolescence and beyond. Nature human behaviour, 2(3), 177-186.

3. As the author notes, the cell sizes for polydrug use and crime and high crime latent classes are very small. Did you consider combining them? Perhaps forcing a 3-class solution makes more sense given that nearly 75% are abstainers and another 22% are normative alcohol only users.

Reviewer #3: A large nationwide study investigated the co-occurrence of self-reported substance use and criminal offending at ages 17/18, as well as whether a range of risk factors, including family, personality, mental health, peers, and others, measured at ages 15/16, predicted these co-occurrences. The findings revealed that it was possible to distinguish four classes of individuals based on their substance use (or non-use) and criminal behavior. Of these, only two classes were characterized by both substance use and criminal behavior, although they were very small. Specific factors appeared to be significant predictors of class membership. Overall, the topic is relevant to the field of study, although I have raised several points that should be addressed before this study can be considered for publication.

In general

Consider using the terms "delinquency" or "delinquent behavior" instead of "criminal behavior," as these terms are more appropriate when discussing adolescence.

Abstract

It would be useful to include the gender distribution in parentheses.

A large portion of the conclusion merely repeats the results. I recommend rewriting the conclusion section to focus on the implications of these findings, rather than restating the results.

Introduction

The first paragraph of the introduction could be strengthened by including more information on the global prevalence of both substance use and criminal behavior among adolescents, with a particular focus on Sweden, as this was the target population in your study. Including this background in the introduction can help better frame the outcomes of your study and underscore the relevance of your findings within both a global and national context.

In addition, within the same paragraph, when emphasizing the importance of your research, it would be beneficial to focus more specifically on the significance of studying the co-occurrence of substance use and delinquency in adolescence.

The continuation of the introduction could benefit from a more specific explanation of why adolescents are particularly susceptible to engaging in substance use and criminal behavior, along with a focus on the most common and important risk factors.

How were substance use and criminal behavior operationalized in your study?

In the section on the present study, it would be useful to specify which particular risk factors you focused on and provide a rationale for why these were selected. For example, if you chose to examine family dynamics, peer influence, or mental health problems, explaining how these factors are linked to both substance use and delinquency in your specific context would strengthen your research justification.

Methods

Participants and Procedure

Were there any inclusion or exclusion criteria for participation in this study?

Please provide more information on sample characteristics (e.g., mean age, ethnicity, SES, etc.) either in the text or in a table.

Measurements

The section on measures would benefit from additional subheadings to group measurements of the same category under a common heading.

Could you provide some examples of how you measured "Other drugs"?

You repeat the sentence "Risk factors were measured at T1" twice. Consider removing it from the first paragraph of the section on measures to avoid redundancy.

The reliability of the measure for callous-unemotional traits was poor. It would be useful to include the mean item correlation and indicate whether it falls within the acceptable range (for more detail, see Clark & Watson, 1995).

Clark, L. A., & Watson, D. (1995). Constructing validity: Basic issues in objective scale development. Psychological Assessment, 7(3), 309–319. https://doi.org/10.1037/1040-3590.7.3.309

Analysis

Please specify which software you used to conduct the latent class analysis.

Based on the literature, BIC is generally regarded as the most reliable criterion for determining the optimal number of classes. However, I recommend also considering entropy, classification error, class sizes, and whether the identified classes are meaningful and consistent with theoretical assumptions or prior research.

Correlations and other statistical findings should be reported in the Results section, not the Methods section.

I suggest that the reference group be mentioned in the Results section rather than in the Methods section, as at this point, it is not yet clear whether classes will be identified among the indicators.

Which software did you use to conduct the ANOVA analysis, and what was the initial number of risk factors considered?

Results

Please remove (AIC=52171.21, BIC=52377.40) from the text, as it is not informative on its own.

Table 1 should include additional relevant information, such as the number of parameters, likelihood ratio or log-likelihood, degrees of freedom, p-value, class error, and the entropy of R2.

In Table 2, you should also include the Wald test, as well as the Wald test for paired comparisons.

In the second paragraph of the Results section, the missing values in parentheses are surprising, given that it was previously mentioned that listwise deletion was employed.

In addition, to enhance readability, avoid placing all information in parentheses. You can write:

The largest class, which comprised 74.8 % of the sample (n = #, % females), scored the lowest on all outcomes and was therefore labeled the “Low/abstainers” class.

The third and fourth classes are very small, which raises questions about their meaningfulness. This relates to my earlier comment about providing more background information on the prevalence of substance use and delinquency in Sweden, as well as offering more detail in the Methods section regarding what class size would be considered acceptable.

Table 3 should include information on the F-test or Chi-Square test. Additionally, the Bonferroni correction should be applied for multiple pairwise comparisons.

The last paragraph of the Results section is unclear regarding which factors were excluded. To improve clarity and make it easier to follow, please mention the excluded factors in the text.

Discussion

In general, the discussion is somewhat limited and would benefit from a deeper analysis grounded in existing literature and empirical findings related to substance use and delinquency in adolescents.

Emphasizing that three classes were identified at T2 may cause confusion, as the first class was also derived from T2 measures. Clarifying this point would improve the paper's flow. Additionally, I recommend avoiding abbreviations and statistical terms in the discussion to enhance readability and clarity.

Alcohol is a significant risk factor for criminal behavior; however, in the "Alcohol only" class of your sample, it did not co-occur with criminal behavior. A broader discussion is needed to explore the possible reasons for this discrepancy. Is it due to the way criminal behavior was operationalized, or are there other factors that are stronger predictors of criminal behavior at this particular developmental stage than alcohol consumption alone? A more comprehensive exploration of these factors would be valuable.

In addition, when describing the third class, you could be more specific by stating that adolescents in this group were more likely to consume a variety of substances, with the highest probability of cannabis use. They were also more likely to commit crimes compared to both the reference category and the second class, although the difference was not so big. The results should be discussed in this context to provide a clearer understanding of the factors at play.

The discussion of the fourth class is superficial and should be grounded in evidence and prior research.

Considering the predictors of the classes, I suggest starting the discussion with the significant results, and then addressing the non-significant ones.

Instead of saying 'considerably higher OR,' explain what it means.

You should give more consideration to how measuring criminal behavior through self-report might influence your results.

Based on the limitations and your findings, are there any recommendations for future research?

What is the added value of your study, and what are the potential clinical implications?

Conclusion

The conclusion section should better summarize the main findings of the study and provide a clear take-home message.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy .

Reviewer #1: Yes:  Malin Hildebrand Karlén

Reviewer #2: No

Reviewer #3: Yes:  Marija Jankovic

**********

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Attachment

Submitted filename: Review 2024-11-28.docx

pone.0322515.s002.docx (20.2KB, docx)
PLoS One. 2025 May 2;20(5):e0322515. doi: 10.1371/journal.pone.0322515.r003

Author response to Decision Letter 0


10 Feb 2025

Thank you for this opportunity for revision. Our responses to the reviewers suggestions can be found in the attached file "response to reviewers"

Thank you!

Sincerely

Clas Björklund

Attachment

Submitted filename: Respone to reviewers.docx

pone.0322515.s004.docx (60.2KB, docx)

Decision Letter 1

Ayse Ulgen

24 Mar 2025

Latent classes of substance use and delinquency in a Swedish national sample of adolescents and associated risk factors

PONE-D-24-39038R1

Dear Dr. Bjorklund,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Ayse Ulgen, PhD, MGM

Academic Editor

PLOS ONE

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #3: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: The author responded to reviewer comments thoroughly and thoughtfully. There are no lingering issues and the manuscript is significantly improved.

Reviewer #3: I do not have any further comments as all my concerns have been adequately addressed.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy .

Reviewer #2: No

Reviewer #3: Yes:  Marija Janković

**********

Acceptance letter

Ayse Ulgen

PONE-D-24-39038R1

PLOS ONE

Dear Dr. Björklund,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

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If revisions are needed, the production department will contact you directly to resolve them. If no revisions are needed, you will receive an email when the publication date has been set. At this time, we do not offer pre-publication proofs to authors during production of the accepted work. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few weeks to review your paper and let you know the next and final steps.

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If we can help with anything else, please email us at customercare@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Ayse Ulgen

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Table. Correlation matrix of indicator variables.

    (DOCX)

    pone.0322515.s001.docx (13.9KB, docx)
    Attachment

    Submitted filename: Review 2024-11-28.docx

    pone.0322515.s002.docx (20.2KB, docx)
    Attachment

    Submitted filename: Respone to reviewers.docx

    pone.0322515.s004.docx (60.2KB, docx)

    Data Availability Statement

    The data for this study are managed by Karolinska Institutet. The Futura01 survey include sensitive information on individuals, as defined by the Swedish Personal Data Act (Personuppgiftslagen, PUL, SFS 1998:204; § 13). Restrictions apply to the availability of these data, which were used under license for this study. Data are available from registrator@ki.se given approval from the Swedish Ethical Review Authority (registrator@etikprovning.se). Access to the data for the purpose of this study was based on membership of a research team with ethical approval for analyses of data from Futura01. Researchers who qualify by getting ethical approval from Swedish authorities can request access to data from the data holder. Data is stored according to the Archives Act (1990:782) and the regulations and general recommendations of the Swedish National Archives concerning the disposal of documents in research activities conducted by government agencies (RA-FS 1999:1).


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