| December 13, 2022 to January 19, 2023 |
ANVISA published two safety alerts: Alert No. 07/2022, about temporary blindness and other undesirable effects, supposedly caused by hair styling creams; and Alert No. 01/2023, which updated this information. |
Cosmetovigilance action |
| December 14, 2022 to June 19, 2023 |
Seventeen news articles published on ANVISA’s internet portal, corresponding to 65.4% of the total news items published in the 25-month period (n=26). |
Marketing authorization, cosmetovigilância, market inspection and laboratory analysis action |
| January 6 to June 27, 2023 |
ANVISA published 66 normative acts, representing 68.7% of the total during the study period (n=96). Of these, 36 were inspection measures, with the majority (69.4%) involving the suspension and recall of hair styling creams, and 30 marketing authorizations, with 86.7% referring to the cancellation of these products. Between December 2022 and June 2023, 809 styling creams had their authorizations canceled. |
Inspection and marketing authorization action |
| January 18, 2023 |
Consultation restricted to the ANVISA Sentinel Hospital Network. The objective of the action was to capture records of care provided to patients with eye problems related to the use of hair styling creams in health units throughout 2022. |
Cosmetovigilance action |
| February 4 to March 27, 2023 |
Field investigation carried out at the Souza Aguiar Municipal Hospital in Rio de Janeiro, with preliminary data from the second week of research conducted by the Training Program on Epidemiology Applied to the Services of the Brazilian Ministry of Health National Health System. A total of 451 patients had been treated at the health unit with ocular adverse events related to styling creams, between December 19, 2022 and January 31, 2023. Other field investigations took place in the municipality of Humaitá (Amazonas) and in the state of Pernambuco. |
Cosmetovigilance action |
| February 10, 2023 |
ANVISA banned all hair styling creams, prohibiting their marketing in Brazil, through Resolution No. 475, dated February 9, 2023, due to reports of serious adverse events. This standard is part of the 66 normative acts mentioned above. |
Market inspection action |
| February 10 to October 27, 2023 |
Six laboratory analysis reports were produced, including results of nuclear magnetic resonance, infrared spectrometry, physical-chemical analyses, chemical analyses, microbiological analyses and toxicological assessment of ocular irritation and corrosion due to hair styling creams. These reports were prepared by public institutions that work in partnership with ANVISA. |
Laboratory analysis action |
| February 8 to March 23, 2023 |
Consultations and responses from international health authorities from ten countries plus the European Union on the occurrence of ocular adverse events related to hair styling creams. All those health authorities replied that they had had no similar cases. |
Cosmetovigilance action |
| March 16 to April 26, 2023 |
Two cosmetovigilance bulletins were made available for internal consultation by ANVISA. The two documents presented, in particular, an epidemiological analysis of cases of ocular adverse events related to styling creams, in terms of time, place and person. |
Cosmetovigilance action |
| March 20, 2023 |
ANVISA authorized marketing of a restricted list of hair styling creams. In the last update of this list, carried out on February 9, 2024, there were 490 hair styling creams that could be sold in Brazil. |
Market inspection action and marketing authorization action |
