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. 1993 Feb;133(2):237–245. doi: 10.1093/genetics/133.2.237

Post-Transcriptional Regulation of RNA Polymerase II Levels in Caenorhabditis Elegans

B K Dalley 1, T M Rogalski 1, G E Tullis 1, D L Riddle 1, M Golomb 1
PMCID: PMC1205314  PMID: 8436272

Abstract

To investigate the regulation of RNA polymerase II levels in Caenorhabditis elegans, we have constructed nematode strains having one, two, or three copies of ama-1, the gene for the largest subunit of RNA polymerase II. Steady-state levels of RNA polymerase II polypeptides and solubilized enzyme activity are invariant with gene dosage, indicating regulatory compensation. However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage. These results imply that RNA polymerase II levels in C. elegans are regulated post-transcriptionally.

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Selected References

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