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. 1994 Jun;137(2):565–572. doi: 10.1093/genetics/137.2.565

Shared Sequence Variants of Mus Spretus Line-1 Elements Tracing Dispersal to within the Last 1 Million Years

N C Casavant 1, S C Hardies 1
PMCID: PMC1205978  PMID: 8070666

Abstract

LINE-1 repetitive sequences contain a record of an evolving population of transposons within the mammalian genome. Of the 100,000 copies of LINE-1 sequences per genome there are many shared sequence variants representing changes occurring within the propagating LINE-1 elements themselves, rather than changes that occur during retrotransposition or after an element inserts in the genome. These shared sequence variants define families of LINE-1 elements which have spread within specific periods of time. We have been interested in studying events in LINE-1 evolution since the speciation of Mus spretus and Mus domesticus approximately 3 million years (Myr) ago. To do this, we have collected LINE-1 sequences that have shared sequence variants specific to M. spretus. The sampled LINE-1 elements were sequenced at their extreme 3' ends, where the density of sequence variants is highest. The new sequences define six new M. spretus-specific sequence variants. Of these, we have found one that could be used to screen for LINE-1 elements arising in the last 1 Myr, which we argue is a critical sample for understanding the dynamics of LINE-1 propagation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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