Abstract
1. The growth factor from Mycobacterium phlei is now named mycobactin P to distinguish it from related but chemically distinct growth factors from other species of mycobacteria. It is shown to comprise four closely similar chemical entities differing only in the fatty side chain. 2. The structure of the main component (85%) of mycobactin P has been established and the absolute configuration of all asymmetric centres determined. 3. Ferric mycobactin P has been crystallized; its structure is discussed. 4. Evidence is given for regarding ferric mycobactin P as a member of the class of compounds known as sideramines, though the mycobactins are more specialized than other sideramines.
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- BICKEL H., GAEUMANN E., KELLER-SCHIERLEIN W., PRELOG V., VISCHER E., WETTSTEIN A., ZAEHNER H. [On iron-containing growth factors, sideramines, and their antagonists, the iron-containing antibiotics, sideromycins]. Experientia. 1960 Apr 15;16:129–133. doi: 10.1007/BF02157712. [DOI] [PubMed] [Google Scholar]
- BURNHAM B. F. Bacterial iron metabolism: investigations on the mechanism of ferrichrome function. Arch Biochem Biophys. 1962 May;97:329–335. doi: 10.1016/0003-9861(62)90085-1. [DOI] [PubMed] [Google Scholar]
- BURNHAM B. F., NEILANDS J. B. Studies on the metabolic function of the ferrichrome compounds. J Biol Chem. 1961 Feb;236:554–559. [PubMed] [Google Scholar]
- BURNHAN B. F. INVESTIGATIONS ON THE ACTION OF THE IRON-CONTAINING GROWTH FACTORS, SIDERAMINES; AND IRON-CONTAINING ANTIBIOTICS, SIDEROMYCINS. J Gen Microbiol. 1963 Jul;32:117–121. doi: 10.1099/00221287-32-1-117. [DOI] [PubMed] [Google Scholar]
- BURTON M. O., SOWDEN F. J., LOCHHEAD A. G. Studies on the isolation and nature of the terregens factor. Can J Biochem Physiol. 1954 Jul;32(4):400–406. [PubMed] [Google Scholar]
- DEMAIN A. L., HENDLIN D. 'Iron transport' compounds as growth stimulators for Microbacterium sp. J Gen Microbiol. 1959 Aug;21:72–79. doi: 10.1099/00221287-21-1-72. [DOI] [PubMed] [Google Scholar]
- FRANCIS J., MACTURK H. M., MADINAVEITIA J., SNOW G. A. Mycobactin, a growth factor for Mycobacterium johnei. I. Isolation from Mycobacterium phlei. Biochem J. 1953 Nov;55(4):596–607. doi: 10.1042/bj0550596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEILANDS J. B. Some aspects of microbial iron metabolism. Bacteriol Rev. 1957 Jun;21(2):101–111. doi: 10.1128/br.21.2.101-111.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS S. J., WARREN R. A., NEILANDS J. B. AMINO-ACID SEQUENCES WITHIN THE FERRICHROME CYCLIC HEXAPEPTIDES. Nature. 1963 Oct 12;200:167–167. doi: 10.1038/200167a0. [DOI] [PubMed] [Google Scholar]
- ZAEHNER H., von BACHMANN M., HUETTER R., NUESCH J. [Sideramines, iron-containing growth factors from micro-organisms]. Pathol Microbiol (Basel) 1962;25:708–736. [PubMed] [Google Scholar]

