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. 1965 Jan;94(1):190–197. doi: 10.1042/bj0940190

An enzyme catalysing the conjugation of epoxides with glutathione

E Boyland 1, K Williams 1
PMCID: PMC1206427  PMID: 14342229

Abstract

1. Liver supernatant preparations from rats and ferrets catalyse the conjugation of some epoxides with glutathione. The enzyme involved might be called `glutathione S-epoxidetransferase', as it is different from glutathione S-aryltransferase, the enzyme catalysing the conjugation of 1,2-dichloro-4-nitrobenzene, 4-nitro-pyridine N-oxide and other cyclic compounds with glutathione and from the enzyme catalysing the conjugation of iodomethane and glutathione. 2. The enzyme does not catalyse the reaction with cysteine. It is not inactivated by dialysis but is unstable at pH 5·0. 3. The role of the enzyme in metabolism of foreign compounds is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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