Abstract
We present methods for using the model of FOSS, LANDE, STAHL and STEINBERG to estimate interference and map distances from two-factor tetrad data. We illustrate the application of the methods with data from Neurospora and from Saccharomyces.
Full Text
The Full Text of this article is available as a PDF (531.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersson L., Haley C. S., Ellegren H., Knott S. A., Johansson M., Andersson K., Andersson-Eklund L., Edfors-Lilja I., Fredholm M., Hansson I. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science. 1994 Mar 25;263(5154):1771–1774. doi: 10.1126/science.8134840. [DOI] [PubMed] [Google Scholar]
- BARRATT R. W., NEWMEYER D., PERKINS D. D., GARNJOBST L. Map construction in Neurospora crassa. Adv Genet. 1954;6:1–93. doi: 10.1016/s0065-2660(08)60127-3. [DOI] [PubMed] [Google Scholar]
- BOLE-GOWDA B. N., PERKINS D. D., STRICKLAND W. N. Crossing-over and interference in the centromere region of linkage group I of Neurospora. Genetics. 1962 Sep;47:1243–1252. doi: 10.1093/genetics/47.9.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barker J. S. Inter-locus interactions: a review of experimental evidence. Theor Popul Biol. 1979 Dec;16(3):323–346. doi: 10.1016/0040-5809(79)90021-2. [DOI] [PubMed] [Google Scholar]
- Bryant E. H., McCommas S. A., Combs L. M. The Effect of an Experimental Bottleneck upon Quantitative Genetic Variation in the Housefly. Genetics. 1986 Dec;114(4):1191–1211. doi: 10.1093/genetics/114.4.1191. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cobbs G. Renewal process approach to the theory of genetic linkage: case of no chromatid interference. Genetics. 1978 Jul;89(3):563–581. doi: 10.1093/genetics/89.3.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cockerham C C. An Extension of the Concept of Partitioning Hereditary Variance for Analysis of Covariances among Relatives When Epistasis Is Present. Genetics. 1954 Nov;39(6):859–882. doi: 10.1093/genetics/39.6.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crow J. F. Population genetics history: a personal view. Annu Rev Genet. 1987;21:1–22. doi: 10.1146/annurev.ge.21.120187.000245. [DOI] [PubMed] [Google Scholar]
- Doebley J., Stec A. Genetic analysis of the morphological differences between maize and teosinte. Genetics. 1991 Sep;129(1):285–295. doi: 10.1093/genetics/129.1.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foss E., Lande R., Stahl F. W., Steinberg C. M. Chiasma interference as a function of genetic distance. Genetics. 1993 Mar;133(3):681–691. doi: 10.1093/genetics/133.3.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foss E., Lande R., Stahl F. W., Steinberg C. M. Chiasma interference as a function of genetic distance. Genetics. 1993 Mar;133(3):681–691. doi: 10.1093/genetics/133.3.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hastings A. Multilocus population genetics with weak epistasis. I. Equilibrium properties of two-locus two-allele models. Genetics. 1985 Apr;109(4):799–812. doi: 10.1093/genetics/109.4.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S., Feldman M. W. Linkage and selection: two locus symmetric viability model. Theor Popul Biol. 1970 May;1(1):39–71. doi: 10.1016/0040-5809(70)90041-9. [DOI] [PubMed] [Google Scholar]
- Karlin S. General two-locus selection models: some objectives, results and interpretations. Theor Popul Biol. 1975 Jun;7(3):364–398. doi: 10.1016/0040-5809(75)90025-8. [DOI] [PubMed] [Google Scholar]
- King J. S., Mortimer R. K. A mathematical model of interference for use in constructing linkage maps from tetrad data. Genetics. 1991 Oct;129(2):597–602. doi: 10.1093/genetics/129.2.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- King J. S., Mortimer R. K. A polymerization model of chiasma interference and corresponding computer simulation. Genetics. 1990 Dec;126(4):1127–1138. doi: 10.1093/genetics/126.4.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lande R., Stahl F. W. Chiasma interference and the distribution of exchanges in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol. 1993;58:543–552. doi: 10.1101/sqb.1993.058.01.061. [DOI] [PubMed] [Google Scholar]
- McPeek M. S., Speed T. P. Modeling interference in genetic recombination. Genetics. 1995 Feb;139(2):1031–1044. doi: 10.1093/genetics/139.2.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mortimer R. K., Hawthorne D. C. Genetic mapping in Saccharomyces. Genetics. 1966 Jan;53(1):165–173. doi: 10.1093/genetics/53.1.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PERKINS D. D. Crossing-over and interference in a multiply marked chromosome arm of Neurospora. Genetics. 1962 Sep;47:1253–1274. doi: 10.1093/genetics/47.9.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Papazian H P. The Analysis of Tetrad Data. Genetics. 1952 Mar;37(2):175–188. doi: 10.1093/genetics/37.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perkins D. D. Biochemical Mutants in the Smut Fungus Ustilago Maydis. Genetics. 1949 Sep;34(5):607–626. doi: 10.1093/genetics/34.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Routman E., Cheverud J. M. Individual genes underlying quantitative traits: molecular and analytical methods. EXS. 1994;69:593–606. doi: 10.1007/978-3-0348-7527-1_35. [DOI] [PubMed] [Google Scholar]
- STRICKLAND W. N. An analysis of interference in Aspergillus nidulans. Proc R Soc Lond B Biol Sci. 1958 Jul 1;149(934):82–101. doi: 10.1098/rspb.1958.0053. [DOI] [PubMed] [Google Scholar]
- Simmons M. J., Crow J. F. Mutations affecting fitness in Drosophila populations. Annu Rev Genet. 1977;11:49–78. doi: 10.1146/annurev.ge.11.120177.000405. [DOI] [PubMed] [Google Scholar]
- Snow R. Maximum likelihood estimation of linkage and interference from tetrad data. Genetics. 1979 May;92(1):231–245. doi: 10.1093/genetics/92.1.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stam P. Interference in Genetic Crossing over and Chromosome Mapping. Genetics. 1979 Jun;92(2):573–594. doi: 10.1093/genetics/92.2.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Szostak J. W., Orr-Weaver T. L., Rothstein R. J., Stahl F. W. The double-strand-break repair model for recombination. Cell. 1983 May;33(1):25–35. doi: 10.1016/0092-8674(83)90331-8. [DOI] [PubMed] [Google Scholar]
- Tachida H., Cockerham C. C. A building block model for quantitative genetics. Genetics. 1989 Apr;121(4):839–844. doi: 10.1093/genetics/121.4.839. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Templeton A. R. The Unit of Selection in DROSOPHILA MERCATORUM. II. Genetic Revolution and the Origin of Coadapted Genomes in Parthenogenetic Strains. Genetics. 1979 Aug;92(4):1265–1282. doi: 10.1093/genetics/92.4.1265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Templeton A. R. The theory of speciation via the founder principle. Genetics. 1980 Apr;94(4):1011–1038. doi: 10.1093/genetics/94.4.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zhao H., Speed T. P., McPeek M. S. Statistical analysis of crossover interference using the chi-square model. Genetics. 1995 Feb;139(2):1045–1056. doi: 10.1093/genetics/139.2.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]