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. 1965 Feb;94(2):331–336. doi: 10.1042/bj0940331

Biosynthesis of l-tyrosine O-sulphate from the methyl and ethyl esters of l-tyrosine

J G Jones 1, K S Dodgson 1
PMCID: PMC1206514  PMID: 14348193

Abstract

1. Rat-liver supernatant preparations are capable of achieving the biological sulphation of l-tyrosine methyl ester, the reaction proceeding maximally at a substrate concentration of 30 mm and at pH 7·0. 2. Two sulphated products are formed, one of which has been identified as l-tyrosine O-sulphate. On the basis of indirect evidence the other product can be assumed to be l-tyrosine O-sulphate methyl ester. 3. An enzyme present in rat-liver supernatant preparations is capable of converting l-tyrosine O-sulphate methyl ester into l-tyrosine O-sulphate. This enzyme is inhibited by l-tyrosine methyl ester. 4. l-Tyrosine ethyl ester also yields two sulphated products when used as an acceptor in the liver sulphating system. One of these has been identified chromatographically as l-tyrosine O-sulphate and the other may be presumed to be l-tyrosine O-sulphate ethyl ester.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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