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. 1995 May;140(1):411–414. doi: 10.1093/genetics/140.1.411

Inversions with Deletions and Duplications

AJE Gordon 1, J A Halliday 1
PMCID: PMC1206566  PMID: 7635304

Abstract

Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back onto the leading-strand template will determine if the inversion is accompanied by deletion and duplication of sequence. We suggest that such strand misalignment-realignment events may occur at the replication fork during concurrent DNA replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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