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. 1965 Mar;94(3):773–777. doi: 10.1042/bj0940773

The inhibition of two steroid-activated nicotinamide–adenine dinucleotide (phosphate) transhydrogenases by folic acid and folic acid antimetabolites

W I P Mainwaring 1, D C Williams 1
PMCID: PMC1206616  PMID: 14340071

Abstract

1. It was found that steroid-mediated nicotinamide–adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.

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Selected References

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