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. 1965 Jun;95(3):832–837. doi: 10.1042/bj0950832

Citrate and the conversion of carbohydrate into fat. Activities of citrate-cleavage enzyme and acetate thiokinase in livers of normal and diabetic rats

Melodee S Kornacker 1, J M Lowenstein 1
PMCID: PMC1206813  PMID: 14342522

Abstract

1. The activity of citrate-cleavage enzyme declines in alloxan-diabetes. 2. The administration of insulin elevates the activity of the enzyme in livers of normal and diabetic animals. Diets high in glucose or fructose elevate the activity of citrate-cleavage enzyme in normal animals, whereas only the diet high in fructose does so in diabetic animals. These observations parallel the effects of insulin, glucose and fructose on fatty acid synthesis in normal and diabetic animals. The effect of fructose is brought into play more rapidly and is larger than the effect of glucose. 3. With one exception acetate thiokinase shows similar changes at a lower level of activity. 4. The results indicate that insulin acts by increasing glucose utilization, and not by exerting a direct effect on citrate-cleavage enzyme or acetate thiokinase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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