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. 1965 Jun;95(3):847–850. doi: 10.1042/bj0950847

The inhibition of nicotinamide–adenine dinucleotide-linked 3α-hydroxy steroid dehydrogenase by certain antimetabolic drugs

R F Lambe 1, D C Williams 1
PMCID: PMC1206815  PMID: 14342524

Abstract

1. The inhibition of NAD-linked 3α-hydroxy steroid dehydrogenase in vitro by some of the more therapeutically effective antimetabolic drugs has been investigated. 2. Antipurine and antifolic acid drugs inhibit this system, as does folic acid. 3. Combinations of antifolic acid drugs and folic acid itself produce an additive but not synergic inhibition. 4. Antimetabolic drugs give inhibitions that are additive to those produced by antagonistic steroid hormones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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