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. 1965 Jul;96(1):205–209. doi: 10.1042/bj0960205

Fluctuations in human serum lipoproteins during the normal menstrual cycle

Marion Barclay 1, R K Barclay 1, V P Skipski 1, Olga Terebus-Kekish 1, C H Mueller 1, Ellen Shah 1, W L Elkins 1,*
PMCID: PMC1206923  PMID: 14343133

Abstract

1. Lipoproteins were measured in sera from 11 young women having a similar environment and diet. Sera were obtained at weekly intervals over a 12-week period. The values of the lipoproteins during periods in the normal ovulatory cycle were compared to assess their relation to reported hormone concentrations in blood. 2. Only the 4–0sf (HDL2) (d 1·125 sodium chloride) fraction changed significantly; it increased at ovulation in ten of the 11 subjects and fell as menstruation approached. 3. There was greater variability in most of the low-density rather than the high-density lipoproteins within individuals. The lipoprotein class most characteristic for an individual was the 4–0sf or HDL2 fraction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARCLAY M., BARCLAY R. K., SKIPSKI V. P. HIGH-DENSITY LIPOPROTEIN CONCENTRATIONS IN MEN AND WOMEN. Nature. 1963 Oct 26;200:362–363. doi: 10.1038/200362b0. [DOI] [PubMed] [Google Scholar]
  2. BARCLAY M., BARCLAY R. K., TEREBUS-KEKISH O., SHAH E. B., SKIPSKI V. P. DISCLOSURE AND CHARACTERIZATION OF NEW HIGH-DENSITY LIPOPROTEINS IN HUMAN SERUM. Clin Chim Acta. 1963 Sep;8:721–726. doi: 10.1016/0009-8981(63)90135-9. [DOI] [PubMed] [Google Scholar]
  3. BARCLAY M., TEREBUS-KEKISH O., SKIPSKI V. P., BARCLAY R. K. ADDITIONAL EVIDENCE FOR THE EXISTENCE OF "NEW" HIGH-DENSITY LIPOPROTEINS IN HUMAN SERUM. Clin Chim Acta. 1965 May;11:389–394. doi: 10.1016/0009-8981(65)90183-x. [DOI] [PubMed] [Google Scholar]
  4. BARR D. P., RUSS E. M., EDER H. A. Influence of estrogens on lipoproteins in atherosclerosis. Trans Assoc Am Physicians. 1952;65:102–113. [PubMed] [Google Scholar]
  5. BEREZIN D., VON STUDNITZ W. The effect of the administration of sex hormones on serum lipids and lipoproteins in women. I. Oestrogens. Acta Endocrinol (Copenh) 1957 Aug;25(4):427–434. doi: 10.1530/acta.0.0250427. [DOI] [PubMed] [Google Scholar]
  6. BEREZIN D., VON STUDNITZ W. The effect of the administration of sex hormones on serum lipids and lipoproteins in women. II. Androgens. Acta Endocrinol (Copenh) 1957 Aug;25(4):435–444. doi: 10.1530/acta.0.0250435. [DOI] [PubMed] [Google Scholar]
  7. BROWN J. B. The metabolism of oestrogens and the measurement of the excretory products in the urine. J Obstet Gynaecol Br Emp. 1959 Oct;66:795–803. doi: 10.1111/j.1471-0528.1959.tb01926.x. [DOI] [PubMed] [Google Scholar]
  8. EILERT M. L. Effect of estrogens on the partition of serum lipids in female patients. Metabolism. 1953 Mar;2(2):137–145. [PubMed] [Google Scholar]
  9. GLASS S. J., ENGELBERG H., MARCUS R., JONES H. B., GOFMAN J. Lack of effect of administered estrogen on the serum lipids and lipoproteins of male and female patients. Metabolism. 1953 Mar;2(2):133–136. [PubMed] [Google Scholar]
  10. GOFMAN J. W., JONES H. B., LINDGREN F. T., LYON T. P., ELLIOTT H. A., STRISOWER B. Blood lipids and human atherosclerosis. Circulation. 1950 Aug;2(2):161–178. doi: 10.1161/01.cir.2.2.161. [DOI] [PubMed] [Google Scholar]
  11. HAVEL R. J., EDER H. A., BRAGDON J. H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955 Sep;34(9):1345–1353. doi: 10.1172/JCI103182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. OLIVER M. F., BOYD G. S. Changes in the plasma lipids during the menstrual cycle. Clin Sci. 1953 May;12(2):217–222. [PubMed] [Google Scholar]
  13. ROBINSON R. W., HIGANO N., COHEN W. D. The effects of estrogens on serum lipids in women. AMA Arch Intern Med. 1957 Nov;100(5):739–743. doi: 10.1001/archinte.1957.00260110055008. [DOI] [PubMed] [Google Scholar]
  14. ROY E. J. Application of the Ittrich extraction procedure to the fluorimetric measurement of oestrogens in blood. J Endocrinol. 1962 Dec;25:361–368. doi: 10.1677/joe.0.0250361. [DOI] [PubMed] [Google Scholar]
  15. RUSS E. M., EDER H. A., BARR D. P. Protein-lipid relationships in human plasma. I. In normal individuals. Am J Med. 1951 Oct;11(4):468–479. doi: 10.1016/0002-9343(51)90182-9. [DOI] [PubMed] [Google Scholar]
  16. VANDENHEUVEL F. A. The origin, metabolism, and structure of normal human serum lipoproteins. Can J Biochem Physiol. 1962 Sep;40:1299–1326. [PubMed] [Google Scholar]

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