Abstract
Plant mating systems often involve a mixture of self fertilizations and outcross fertilizations. The degree of selfing has a large impact on the genetic composition of natural populations and on the evolution of the mating system itself in response to such factors as inbreeding depression. This paper describes a means of estimating the long-term rate of self-fertilization from samples of alleles taken from individuals in a population. Use is made of the genealogy of pairs of alleles at a locus within individuals and pairs between individuals. The degree of selfing is closely related to the extent to which the number of nucleotide sites differing within an individual is reduced relative to the number differing between individuals. Importantly, the estimate of long-term selfing is largely independent of population size and is not affected by historical fluctuations in population size; instead it responds directly to the mating system itself. The approach outlined here is most appropriate to evolutionary problems in which the long-term nature of the mating system is of interest, such as to determine the relationship between prior inbreeding and inbreeding depression.
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Selected References
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- Brown A. H., Allard R. W. Estimation of the mating system in open-pollinated maize populations using isozyme polymorphisms. Genetics. 1970 Sep;66(1):133–145. doi: 10.1093/genetics/66.1.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ewens W. J. The sampling theory of selectively neutral alleles. Theor Popul Biol. 1972 Mar;3(1):87–112. doi: 10.1016/0040-5809(72)90035-4. [DOI] [PubMed] [Google Scholar]
- Fu Y. X. A phylogenetic estimator of effective population size or mutation rate. Genetics. 1994 Feb;136(2):685–692. doi: 10.1093/genetics/136.2.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fu Y. X. Estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of DNA sequences. Genetics. 1994 Dec;138(4):1375–1386. doi: 10.1093/genetics/138.4.1375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuhner M. K., Yamato J., Felsenstein J. Estimating effective population size and mutation rate from sequence data using Metropolis-Hastings sampling. Genetics. 1995 Aug;140(4):1421–1430. doi: 10.1093/genetics/140.4.1421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lessa E. P., Applebaum G. Screening techniques for detecting allelic variation in DNA sequences. Mol Ecol. 1993 Apr;2(2):119–129. doi: 10.1111/j.1365-294x.1993.tb00006.x. [DOI] [PubMed] [Google Scholar]
- Lessa E. P. Rapid surveying of DNA sequence variation in natural populations. Mol Biol Evol. 1992 Mar;9(2):323–330. doi: 10.1093/oxfordjournals.molbev.a040723. [DOI] [PubMed] [Google Scholar]
- Nei M., Tajima F. DNA polymorphism detectable by restriction endonucleases. Genetics. 1981 Jan;97(1):145–163. doi: 10.1093/genetics/97.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ritland K. The effective proportion of self-fertilization with consanguineous matings in inbred populations. Genetics. 1984 Jan;106(1):139–152. doi: 10.1093/genetics/106.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schoen D. J., Clegg M. T. Estimation of mating system parameters when outcrossing events are correlated. Proc Natl Acad Sci U S A. 1984 Aug;81(16):5258–5262. doi: 10.1073/pnas.81.16.5258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Slatkin M. Inbreeding coefficients and coalescence times. Genet Res. 1991 Oct;58(2):167–175. doi: 10.1017/s0016672300029827. [DOI] [PubMed] [Google Scholar]
- Watterson G. A. On the number of segregating sites in genetical models without recombination. Theor Popul Biol. 1975 Apr;7(2):256–276. doi: 10.1016/0040-5809(75)90020-9. [DOI] [PubMed] [Google Scholar]