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. 2025 May 13;25:715. doi: 10.1186/s12903-025-06086-z

Global, regional, and national caries of permanent teeth incidence, prevalence, and disability-adjusted life years, 1990-2021: analysis for the global burden of disease study

Zhiyuan Li 1, Chenhang Yu 2,, Huan Chen 3,
PMCID: PMC12070580  PMID: 40361035

Abstract

Objectives

This study aims to analyze the global, regional, and national incidence, prevalence, and disability-adjusted life years (DALYs) related to caries of permanent teeth from 1990 to 2021, as part of the Global Burden of Disease Study (GBD).

Study design and methods

Data on incidence, prevalence, and DALYs were extracted and analyzed for various demographic and regional categories. Age-standardized incidence rates (ASIR), age-standardized prevalence rates (ASPR), and age-standardized DALY rates (ASDAR) were calculated. Temporal trends and associations with sociodemographic index (SDI) were also examined.

Results

In 2021, there were approximately 2.37 billion cases of caries of permanent teeth, with an ASIR of 29,777.03 per 100,000 population. The prevalence was around 2.24 billion, with an ASPR of 27,543.34 per 100,000. Females exhibited a higher disease burden than males, and the burden increased with age, peaking in the 20–24 age group. Regions with lower SDI showed higher ASIRs, while the highest burden was noted in Tropical Latin America. Significant increases in disease burden were observed from 1990 to 2021, particularly in China and Colombia, while Japan showed a decrease. The Bayesian age-period-cohort (BAPC) predictions indicate that the burden of caries of permanent teeth will continue to increase year by year.

Conclusion

The burden of caries of permanent teeth varies significantly across regions and demographics, with higher rates in lower SDI areas. The findings underscore the importance of targeted interventions and resource allocation in high-burden regions to improve dental health outcomes.

Supplementary Information

The online version contains supplementary material available at 10.1186/s12903-025-06086-z.

Keywords: Caries of permanent teeth, Global burden of disease, Incidence, Prevalence, DALYs, Socioeconomic factors

Introduction

Caries of permanent teeth, a highly prevalent chronic disease, poses a substantial burden on global health and well-being. Understanding its temporal trends, geographical variations, and disease burden in terms of incidence, prevalence, and disability-adjusted life years (DALYs) is critical for informing public health policies and interventions aimed at mitigating its impact. Previous research, such as the Global Burden of Oral Diseases studies, has underscored the significant contribution of dental caries to the overall oral health burden worldwide [1, 2]. However, a comprehensive and updated analysis encompassing recent data spanning three decades is lacking, which limits our understanding of the evolving caries landscape and hinders the development of effective strategies to address this pressing health issue.

Existing studies often lack detailed temporal trend analyses, geographical comparisons at fine resolutions, and in-depth explorations of the drivers behind observed patterns. Furthermore, oral diseases, including dental caries, have been increasingly recognized as integral to overall health and well-being, with links to various systemic conditions such as cardiovascular disease, diabetes, and respiratory illnesses [3, 4]. Therefore, addressing the burden of caries of permanent teeth is not merely an oral health concern but a crucial aspect of promoting overall population health.

Notably, the distribution of caries burden is heterogeneous, with notable disparities across geographical regions and socioeconomic strata. Low- and middle-income countries often bear a disproportionately higher burden due to limited access to oral healthcare services, poor oral hygiene practices, and unhealthy diets [5, 6]. This study aims to delve deeper into these issues, highlighting these disparities and their implications for global health equity.

To fill this knowledge gap, we leverage the rigorous methodology and extensive data sources of the Global Burden of Disease (GBD) framework. By utilizing GBD estimates, this study seeks to: (1) quantify the incidence, prevalence, and DALYs of caries of permanent teeth globally, regionally, and nationally; (2) analyze temporal trends in these metrics over the past three decades; and (3) identify key drivers of the observed patterns and variations, specifically focusing on sex, age, socioeconomic factors, and geographic location. By addressing these specific deficiencies in the existing research, this study aims to contribute significantly to our understanding of dental caries and its impact on global health.

Building on this rationale, the present study aimed to analyze the global, regional, and national trends in the incidence, prevalence, and DALYs of caries of permanent teeth from 1990 to 2021, utilizing the comprehensive data and methodology of the GBD 2021 study. By identifying key trends and drivers, we hope to inform more targeted and effective strategies to reduce the burden of dental caries globally, thereby promoting overall population health and equity.

Methods

This retrospective study analyzed the burden of caries of permanent teeth across 204 countries and territories from 1990 to 2021. Below, we detail the data sources, estimation frameworks, and statistical approaches used to address the study’s objectives.

Data sources and estimation methods

Data for this study were sourced from the GBD 2021 database, which integrates diverse datasets including cancer registries, population surveys, published literature, and surveillance systems. The GBD 2021 framework harmonizes these data through a multi-step process:

  1. Data Harmonization: Definitions, classifications, and measurement units were aligned across sources to ensure consistency in health outcome reporting. Disease categories were mapped to a common taxonomy, minimizing discrepancies in case definitions.

  2. Population Standardization: Age-standardized rates were applied to account for demographic variations, enabling equitable comparisons across populations.

  3. Geographical and Temporal Adjustment: Data were aggregated to common geographical resolutions (e.g., national levels) and adjusted for temporal trends to reduce confounding from regional or period-specific biases.

To address missing data, the GBD 2021 employed:

  1. Imputation Techniques: Multiple imputation and regression-based methods estimated missing values using covariate patterns and temporal trends.

  2. Data Extrapolation: Subnational gaps were filled using hierarchical models that borrowed strength from analogous regions or higher aggregation levels.

The GBD employs a systematic and standardized approach to estimate health outcomes, including the use of DisMod-MR 2.1, a Bayesian meta-regression tool, to ensure consistency and comparability across locations and time [7].

To address data limitations, particularly the reliance on secondary sources and the lack of granular geographic information for large countries like China, DisMod-MR 2.1 incorporates a series of methods to handle data sparsity and uncertainty. These include the use of hierarchical models, which borrow strength across related geographical units or time points, and the application of smoothing techniques to produce plausible estimates even in areas with limited data [8]. However, it is acknowledged that these methods may introduce some biases, and the resulting estimates should be interpreted with caution, particularly in regions where data scarcity is a concern.

The GBD 2021 database provided data for 204 countries and territories. For geographical analysis, the 204 countries and territories were segmented into 54 GBD regions. Moreover, these same countries were categorized by socioeconomic development status into five Sociodemographic Index (SDI) levels: low, low-middle, middle, high-middle, and high. The methodological framework of the GBD 2021 has been described in prior studies [9, 10]. All data, along with their respective 95% uncertainty intervals (UIs), were derived from various sources, including cancer registries, published studies, surveillance data, census data, and other relevant sources [11]. The estimates were tailored to specific locations, sexes, and age groups. The DALYs were calculated by aggregating the Years lived with disability (YLDs) and Years of Life Lost (YLLs) for each respective cause [12].

For regions lacking longitudinal data, incidence rates were estimated via:

  1. Cross-Sectional Studies: Prevalence data were converted to incidence estimates using disease duration and mortality rates.

  2. Expert Elicitation: Field experts provided contextual insights for underdocumented outcomes.

  3. Spatial–Temporal Modeling: Bayesian frameworks integrated sparse data with covariates (such as socioeconomic indicators) to generate plausible estimates.

Statistical analyses

The statistical analyses conducted in this study were comprehensive and rigorous. First, in 2021, incidence, prevalence, and DALYs of caries of permanent teeth, along with corresponding Age-Standardized Rates (ASRs), were assessed globally and by subtypes such as age, sex, SDI regions, GBD regions, and countries. Second, a thorough analysis was carried out to investigate the temporal trends of this disease burden globally and by subtype from 1990 to 2021. A linear regression model was used to calculate the estimated annual percentage change (EAPC).

In addition, the relationship between EAPCs, caries of permanent teeth-related ASRs in 1990, and Human Development Index (HDI) in 2021 was assessed. Because these three factors were not normally distributed, the Spearman correlation analysis was used to investigate their associations. Furthermore, a hierarchical cluster analysis was carried out, using the EAPC values, to analyze the changing patterns of disease burden across various GBD regions and find those with comparable tendencies. As a result, all 54 GBD locations were divided into four unique categories: substantial rise, slight increase, steady or small drop, and significant decrease.

Moreover, we used the Bayesian Age-Period-Cohort (BAPC) model, together with nested Laplace approximations, to forecast the future illness burden from 2022 to 2046. The BAPC model was chosen for our forecasting analysis due to its ability to account for complex dependencies between age, period, and cohort effects, which are often present in epidemiological data. This model allows for the simultaneous estimation of these effects, providing a more nuanced understanding of trends and patterns over time. Additionally, the Bayesian framework enables the incorporation of prior information and the quantification of uncertainty in our estimates, which is crucial for making informed decisions in public health policy and practice.

Decomposition analyses were used to look deeper into the mechanisms driving changes in the illness burden between 1990 and 2021, with an emphasis on age structure, population size, and epidemiological alterations. Finally, frontier analysis was used to determine the relationship between disease burden and socioeconomic development. By developing a nonlinear frontier, we were able to determine the lowest possible burden based on a country's or region's current development state. Non-parametric data envelope analysis was used to facilitate this research, with earlier studies providing methodological direction. The effective difference, which represents the gap between the observed DALY rate and the frontier, represents the potential health improvements that could be realized at the current level of development.

Statistical significance was determined at a P-value of less than 0.05. We used R software (version 4.0.2) to generate, collate, and analyze the database.

Results

The disease burden attributable to caries of permanent teeth in 2021

The disease burden attributable to caries of permanent teeth in 2021 is significant. Specifically, the number of incidence cases reached 2,370,414,032, with a range of 2,099,098,156 to 2,661,346,388, corresponding to an age-standardized incidence rate (ASIR) of 29,777.03 per 100,000 population, ranging from 26,310.27 to 33,490.91. Similarly, the number of prevalence cases amounted to 2,242,874,758, ranging from 1,957,579,677 to 2,599,622,169, with an age-standardized prevalence rate (ASPR) of 27,543.34 per 100,000 population, varying between 23,976 and 32,018.09. Additionally, the number of DALYs cases was 2,198,064, with a range of 988,183 to 4,174,725, corresponding to an age-standardized DALY rate (ASDAR) of 27.02 per 100,000 population, ranging from 12.1 to 51.36 (Tables 1, 2 and 3).

Table 1.

The number of incidence cases and the age-standardized incidence rate attributable to caries of permanent teeth in 1990 and 2021 and its trends from 1990 to 2021 globally

Number of incidence cases (95% UI) in 1990 The age-standardized incidence rate/100000 (95% UI) in 1990 Number of incidence cases (95% UI) in 2021 The age-standardized incidence rate/100000 (95% UI) in 2021 EAPC (95% CI)
Global 1527618388 (1329926847–1740865232) 28091.58 (24489.95–31836.26) 2370414032 (2099098156–2661346388) 29777.03 (26310.27–33490.91) 0.23 (0.2–0.26)
Sex
 Female 764829981 (666728069–868205308) 28373.11 (24800.95–32071.45) 1179064868 (1045956816–1324945906) 29877.72 (26437.48–33602.38) 0.23 (0.19–0.26)
 Male 762788407 (661968864–872513572) 27824.43 (24222.86–31679.78) 1191349164 (1052116661–1337867524) 29678.33 (26169.01–33359.6) 0.23 (0.21–0.25)
Age
 5–9 years 104867522 (52004029–181258915) 17971.21 (8911.96–31062.45) 111399490 (55654635–197328050) 16214.09 (8100.48–28720.91) −0.2 (−0.27–0.13)
 10–14 years 179245435 (122599522–242863180) 33461.13 (22886.6–45337.14) 234985412 (160000535–319574382) 35249.44 (24001.19–47938.37) 0.21 (0.15–0.28)
 15–19 years 208319379 (161240214–257395353) 40105.89 (31042.15–49554.05) 288411039 (226734324–354013171) 46221.21 (36336.8–56734.71) 0.47 (0.44–0.5)
 20–24 years 241465792 (192472585–289875194) 49069.65 (39113.46–58907.2) 324412059 (263901543–379505989) 54325.99 (44192.91–63552.01) 0.34 (0.32–0.36)
 25–29 years 197366964 (147291983–247704208) 44590.65 (33277.33–55963.22) 286313878 (220180486–348927834) 48664.43 (37423.82–59306.85) 0.34 (0.31–0.38)
 30–34 years 151466906 (115747929–183546332) 39298.93 (30031.44–47622.11) 252878319 (196171016–301713807) 41834.01 (32452.85–49912.94) 0.29 (0.23–0.34)
 35–39 years 120298454 (91659585–147910117) 34151.98 (26021.58–41990.76) 206235228 (159506736–249985406) 36770.85 (28439.36–44571.32) 0.27 (0.23–0.31)
 40–44 years 87843014 (67027574–111870923) 30662.7 (23396.81–39049.95) 163056644 (125374016–206635224) 32594.98 (25062.23–41306.33) 0.21 (0.19–0.24)
 45–49 years 63635852 (49923961–80485693) 27406.15 (21500.83–34662.9) 134127726 (106545483–169604200) 28326.59 (22501.47–35818.91) 0.13 (0.08–0.17)
 50–54 years 51568264 (39195168–66791560) 24259.26 (18438.58–31420.76) 108417964 (83694273–138558102) 24367.8 (18810.96–31142.04) 0.06 (0.02–0.11)
 55–59 years 39127120 (29843800–50303134) 21126.96 (16114.37–27161.53) 83070474 (63167534–106518454) 20991.81 (15962.36–26917.09) 0.05 (0.02–0.07)
 60–64 years 30494416 (23411068–39005392) 18986.71 (14576.41–24285.9) 60798347 (47115300–77612426) 18996.64 (14721.33–24250.26) −0.02 (−0.05–0.01)
 65–69 years 21412647 (17046384–27611119) 17322.82 (13790.52–22337.38) 46411498 (37007765–59582909) 16825.38 (13416.28–21600.36) −0.1 (−0.13–0.08)
 70–74 years 13352878 (10241022–17760878) 15772.14 (12096.48–20978.78) 31469300 (24484669–41314580) 15288.29 (11895.05–20071.29) −0.11 (−0.16–0.07)
 75–79 years 9414369 (7198791–12281147) 15294.11 (11694.8–19951.34) 18768014 (14579538–24471218) 14230.65 (11054.79–18555.05) −0.15 (−0.21–0.1)
 80–84 years 5098490 (3893454–6552459) 14412.32 (11005.94–18522.37) 11623756 (8956045–14947420) 13271.69 (10225.77–17066.57) −0.21 (−0.26–0.16)
 85–89 years 2032044 (1549558–2602858) 13447.38 (10254.45–17224.84) 5570056 (4326156–7075925) 12182.5 (9461.91–15476.05) −0.25 (−0.28–0.22)
 90–94 years 508774 (364850–674121) 11872.86 (8514.21–15731.43) 1962618 (1413187–2596897) 10970.86 (7899.59–14516.42) −0.28 (−0.3–0.26)
 95 + years 100067 (55211–153613) 9828.95 (5423.04–15088.38) 502211 (282029–766053) 9214.37 (5174.55–14055.22) −0.22 (−0.3–0.15)
SDI region
 High-middle SDI 286672766 (249434472–328582906) 25928.82 (22532.92–29735.87) 354901014 (312769941–402702372) 28068.89 (24352.04–31973.91) 0.39 (0.3–0.48)
 High SDI 273099853 (244997182–301645977) 30412.41 (27047.52–33661.65) 311697352 (280824483–345208230) 30049.02 (26769.17–33354.51) 0.02 (−0.02–0.06)
 Low-middle SDI 351990156 (303692201–403346112) 30900.69 (26974.62–35103.05) 623984154 (545108731–703956895) 31182.47 (27260.31–35209.32) −0.03 (−0.09–0.03)
 Low SDI 138385602 (120948207–157279709) 29298.84 (25980.17–32898.15) 330220061 (288016584–375331729) 29403.82 (25801.98–33007.58) −0.02 (−0.05–0.01)
 Middle SDI 475902508 (406309069–550193824) 26442.49 (22826.55–30343.41) 747613546 (661350067–845051324) 29951.73 (26314.08–33821.61) 0.51 (0.44–0.57)
GBD region
 Advanced Health System 417740839 (373267671–465144786) 31203.62 (27640.41–34768.96) 450128126 (405317871–501379807) 30818.7 (27262.48–34386.85) 0 (−0.04–0.04)
 Africa 175398362 (152166992–201049302) 28851.96 (25420.83–32672.85) 402823988 (348744272–458982458) 28927.95 (25414.87–32549.82) 0 (−0.01–0)
 African Region 137664596 (119198102–158130162) 28286.93 (24954.71–32053.7) 330368722 (285886535–376686843) 28424.61 (25033.2–32133.14) 0.01 (0–0.02)
 America 236221402 (204576826–266444945) 32253.86 (28089.71–36357.09) 332618029 (295310714–373527077) 32007.59 (28127.22–35972.74) 0.01 (−0.03–0.05)
 Andean Latin America 11422358 (9738319–13378413) 30057.45 (25809.49–35224.58) 20612023 (17847968–24012910) 30428.82 (26375.99–35415.01) 0.1 (0.08–0.12)
 Asia 859943533 (738216412–992929374) 26180.71 (22784.97–29977.27) 1377369158 (1217900124–1551064542) 29203.89 (25718.77–32956.87) 0.41 (0.37–0.45)
 Australasia 5537911 (4884894–6314576) 26089.96 (23042.65–29717.65) 8935335 (7731234–10359671) 29326.35 (25154.78–33967.29) 0.49 (0.44–0.54)
 Basic Health System 609756172 (522190468–704421627) 25192.82 (21737.08–28988.38) 908265113 (801008253–1029075774) 28936.78 (25264.29–32868.35) 0.6 (0.5–0.71)
 Caribbean 11576085 (10039559–13195466) 32306.77 (28118.52–36763.99) 15723375 (14098738–17416276) 32776.95 (29399.94–36352.97) 0.05 (0.04–0.07)
 Central Africa 17431785 (14282598–21040669) 27893.94 (23379.45–33110.73) 46342262 (38016362–55189979) 27969.26 (23655.54–32816.36) 0.01 (−0.01–0.03)
 Central Asia 21603889 (18320452–25052847) 31431.9 (26902.51–36171.96) 30600881 (26283869–35355328) 31938.39 (27490.82–36708.29) 0.05 (0.03–0.07)
 Central Europe 39224725 (34563010–44135808) 30953.38 (27066.75–34794.29) 36233922 (32321389–40767206) 32337.43 (28381.99–36187.34) 0.15 (0.14–0.16)
 Central Latin America 51245827 (43369765–59733846) 30753.36 (26477.45–35165.96) 80572384 (70351726–92025642) 30652.14 (26663.65–35143.77) −0.04 (−0.07–0.02)
 Central Sub-Saharan Africa 14516280 (11898078–17521056) 27965.16 (23449.19–33017.44) 38137314 (31332985–45565264) 28039.29 (23456.45–32874.64) 0 (−0.01–0.02)
 Commonwealth High Income 33690553 (29958376–37472519) 29775.84 (26370.22–33188.13) 42356311 (37767857–47237375) 30258.25 (26671.92–33927.29) 0.08 (0.06–0.09)
 Commonwealth Low Income 53093245 (44445751–62823580) 26809.29 (22951.38–31135.01) 110282014 (93046508–128962680) 27607.11 (23439.78–32139.1) 0.02 (0–0.04)
 Commonwealth Middle Income 359779076 (311773089–409614823) 30929.02 (27119.15–34973.79) 691564235 (610829712–772347901) 31221.57 (27676.23–34873.5) −0.06 (−0.16–0.03)
 East Asia 236801798 (194684621–285550049) 17834.57 (14643.46–21452.69) 323692711 (282149935–374427839) 23398.84 (20107.29–27254.18) 1.27 (1–1.55)
 East Asia & Pacific—WB 458631818 (393196928–534226008) 23109.1 (19859.38–26805.34) 627765709 (555683784–711382135) 27153.48 (23661.55–30866.29) 0.76 (0.6–0.91)
 Eastern Africa 48051407 (42024473–54610809) 28800.67 (25629.94–32473.62) 115758613 (101414911–131731262) 29154.56 (25748.54–32803.81) 0.02 (0.01–0.03)
 Eastern Europe 77185222 (67474757–87383015) 33949.74 (29643.94–38296.11) 68014273 (59764859–76357341) 33777.23 (29488.46–38087.77) −0.01 (−0.03–0.01)
 Eastern Mediterranean Region 115992165 (99433030–131951795) 31710.75 (27672.35–35769.1) 245487700 (211314405–278252336) 31636.91 (27459.84–35784.18) −0.01 (−0.03–0.01)
 Eastern Sub-Saharan Africa 51283540 (44937664–58260723) 28227.99 (25224.66–31789.07) 125253490 (109269034–142515019) 28721.28 (25373.71–32337.82) 0.03 (0.01–0.04)
 Europe 253158434 (225144959–283971729) 31396.5 (27902.79–35096.34) 254380352 (226391514–284696462) 31571.77 (27896.28–35346.1) 0.04 (0.02–0.06)
 Europe & Central Asia—WB 268196304 (238313211–300823075) 31367.91 (27832.92–35096.32) 277568765 (246881265–311199171) 31549.47 (27843.49–35414.1) 0.04 (0.02–0.06)
 European Region 270537794 (240340724–303469525) 31373.07 (27835.68–35103.78) 281541033 (250479328–315670373) 31573.76 (27872.22–35444.18) 0.04 (0.02–0.06)
 High-income Asia Pacific 57156163 (50711786–63608032) 31494.6 (27707.48–35385.67) 47155095 (42059380–52278109) 28451.18 (25056.24–31636.16) −0.33 (−0.4–0.27)
 High-income North America 91714847 (80175149–103093689) 31848.63 (27596.8–35912.45) 111272043 (97364953–125022962) 30898.22 (26814.08–34828.49) 0.01 (−0.09–0.12)
 Latin America & Caribbean—WB 145765908 (124852106–166408728) 32626.76 (28336.93–37168.06) 222494463 (196155670–252243747) 32765.73 (28704.71–37094.82) 0.02 (0.01–0.04)
 Limited Health System 463824506 (401494627–529620466) 30244.72 (26588.57–34243.41) 917638374 (808290499–1029716401) 30592.45 (27066.35–34314.03) −0.04 (−0.11–0.03)
 Middle East & North Africa—WB 81581936 (70263439–93255314) 31961.84 (27915.51–36290.83) 158120598 (138188127–179424038) 32169.18 (28252.22–36378.71) 0.03 (0.01–0.04)
 Minimal Health System 34729366 (28932558–41391001) 27692.7 (23697.62–32575.34) 92384515 (76947321–109738690) 28190.77 (24045.48–33048.53) 0.04 (0.03–0.06)
 North Africa and Middle East 106426719 (91183653–122008711) 31592.38 (27499.44–35933.27) 204990376 (177919912–233769636) 31920.12 (27848.93–36314.86) 0.05 (0.03–0.07)
 North America 91715993 (80176785–103095404) 31849.63 (27598.06–35913.15) 111275852 (97368778–125027728) 30899.29 (26815.48–34829.5) 0.01 (−0.09–0.12)
 Northern Africa 37931288 (32472950–43272489) 31355.9 (27262.94–35405.81) 67426315 (58666799–76111638) 31591.01 (27582.39–35576.24) 0.01 (0–0.02)
 Oceania 1837448 (1525180–2209102) 27627.61 (23259.61–32988.56) 3911098 (3219170–4637583) 27635.38 (22847.53–32571.56) 0 (−0.02–0.01)
 Region of the Americas 236221402 (204576826–266444945) 32253.86 (28089.71–36357.09) 332618029 (295310714–373527077) 32007.59 (28127.22–35972.74) 0.01 (−0.03–0.05)
 South-East Asia Region 411484558 (355813066–470154068) 31529.69 (27651.91–35800.51) 703183382 (621977393–787897071) 32113.61 (28381.97–36037.29) −0.02 (−0.12–0.08)
 South Asia 332888724 (286601635–381592312) 30880.64 (26918.38–35088.5) 617008020 (540954812–693310573) 31398.81 (27644.28–35248.05) −0.06 (−0.16–0.04)
 South Asia—WB 341666351 (294346102–391745907) 30915.1 (26968.49–35143.21) 634257706 (555645253–713054588) 31436 (27669.55–35330.27) −0.06 (−0.15–0.04)
 Southeast Asia 163386026 (141193084–185122003) 34487.73 (30005.87–38966.91) 251719025 (222051346–283438580) 34776.97 (30584.21–39145.79) 0.08 (0.03–0.14)
 Southern Africa 24832207 (21405856–28893267) 26884.34 (23586.01–30880.32) 52115737 (44607190–60342049) 27926.12 (24297.97–31923.65) 0.12 (0.11–0.14)
 Southern Latin America 15132665 (12739405–17624645) 30289.97 (25546.19–35317.27) 20726146 (18295171–23744186) 30254.87 (26673.86–34580.95) 0.02 (−0.04–0.09)
 Southern Sub-Saharan Africa 14096469 (12086725–16491157) 26634.42 (23217.48–30801.76) 23212833 (20181175–26689599) 27538.17 (23935.06–31619.38) 0.15 (0.13–0.17)
 Sub-Saharan Africa—WB 137875440 (119459360–158285140) 28242.38 (24987.8–31996.82) 336238125 (290474512–384003403) 28365.98 (25002.06–32033.97) 0.01 (0–0.01)
 Tropical Latin America 56801906 (48975225–64633480) 36093.49 (31280.87–41000.71) 85414444 (74738421–96551908) 36541.09 (31903.79–41303.27) 0.07 (0.04–0.1)
 Western Africa 47151675 (40992383–53649031) 28619.93 (25218.34–32124.66) 121181061 (105414531–137183583) 28058.48 (24904.81–31302.35) −0.06 (−0.08–0.04)
 Western Europe 115917670 (104686506–128791649) 30341.19 (27244.68–33773.27) 121534480 (108941434–134792631) 30501.87 (27074.64–33938.98) 0.05 (0.03–0.08)
 Western Pacific Region 349775396 (296111904–410639982) 21204.88 (17966.46–24840.59) 470936234 (414059305–537271117) 25721.06 (22424.58–29449.65) 0.91 (0.71–1.1)
 Western Sub-Saharan Africa 51862113 (44802418–59219498) 28528.64 (25014.32–32116.93) 135694764 (117385625–154500800) 28028.66 (24756.07–31354.85) −0.05 (−0.07–0.03)
 World Bank High Income 320889388 (287779622–355971985) 30656.5 (27256.59–34083.93) 354537560 (319589155–393203894) 30302.51 (26888.48–33777.46) 0.02 (−0.03–0.06)
 World Bank Low Income 81161239 (69927439–93838525) 27525.63 (24190.22–31405.66) 197230488 (169527265–227743665) 28302.82 (24777.52–32234.86) 0.1 (0.09–0.11)
 World Bank Lower Middle Income 623229358 (541403656–708991857) 31673.47 (27740.92–35867.43) 1131452007 (996644266–1267302754) 31773.64 (28035.78–35667.85) −0.04 (−0.11–0.02)
 World Bank Upper Middle Income 500764366 (428874454–581591136) 23844.16 (20530.64–27574.87) 685190267 (602262102–780597826) 27499.85 (23847.47–31494.17) 0.65 (0.52–0.78)
Country
 Afghanistan 2790901.12 (2353268.373254192.77) 30216.71 (25815.2635376.63) 9552431.12 (7941740.5311278648.13) 31130.86 (26565.0336275.6) 0.324(0.2870.361)
 American Samoa 13881.25 (11517.2316401.59) 28255.27 (23723.0333100.34) 14385.32 (12044.9216608.82) 28299.09 (23876.0132869.76) 0.002 (−0.0110.016)
 Angola 2748941.18 (2246033.343297144.86) 28290.39 (23682.2233169.09) 8852796.52 (7204090.6710741356.23) 28394.21 (23428.1533237.63) −0.039 (−0.070-0.008)
 Antigua and Barbuda 20062.57 (17196.0723256.96) 32561.84 (27865.3137472.93) 30528.8 (26285.5135052.36) 32990.74 (28163.9637928.91) 0.148 (0.1270.168)
 Arab Republic of Egypt 17024356.11 (13984950.3320115964.17) 31164.09 (26405.5536604.7) 33839785.51 (28378767.2539234591.49) 31727.7 (27034.1836366.38) 0.081 (0.0150.148)
 Argentine Republic 10086260.09 (8490160.2911795986.6) 30484.24 (25587.1635646.45) 14083087.78 (12073673.8316539672.52) 30429.52 (26020.3235644.62) −0.003 (−0.0410.035)
 Australia 4446080.28 (3889540.25154614.38) 25160.72 (22082.8829058.35) 7285048.85 (6286994.868482010.14) 28787.79 (24571.2533522.34) 0.318 (0.2610.375)
 Bangladesh 27944651 (22813881.7633458890.77) 26993.22 (22745.7431567.64) 47816769.27 (39797072.756019996.02) 27569.79 (22938.632113.78) 0.294 (0.2510.337)
 Barbados 85446.77 (72024.3198965.83) 32517.88 (27692.2637571.99) 100133.86 (86220.47117014.13) 33008.84 (28274.2338850.85) −0.001 (−0.0210.020)
 Belize 59112.4 (52318.1166313.52) 31605.43 (28037.6135024.47) 147822.55 (129715.18169816.09) 31819.52 (28005.4636370.44) 0.240 (0.2220.259)
 Benin 1190604 (983495.71460636.11) 27535.27 (23245.1532504.99) 3575355.97 (2918996.094292567.38) 27511.14 (23287.0332278.41) 0.264 (0.2490.279)
 Bermuda 20235.26 (17199.4323569.74) 32921.17 (27796.8238025.53) 20669.23 (17608.2624228.73) 33282.16 (28262.9638916.35) −0.099 (−0.115-0.082)
 Bhutan 171480.42 (140702.89204623.16) 26955.54 (22416.1431285.26) 228271.07 (189834.29270532.17) 27476.04 (22835.232611.1) 0.343 (0.3120.374)
 Bolivarian Republic of Venezuela 6727851.38 (5786959.017673226.72) 35718.64 (31005.9440506.99) 9650213.73 (8435440.3410892298.56) 36163.4 (31573.5840974.71) 0.146 (0.0830.210)
 Bosnia and Herzegovina 1380645.38 (1191696.691601491.5) 29877.84 (25946.3134506.69) 1028370.81 (895499.871181577.93) 31735.72 (27378.1536433.02) 0.154 (0.1010.208)
 Botswana 313867.04 (252226.59389254.79) 24454.69 (20156.1529523.34) 623733.39 (524659.48756008.15) 24282.53 (20505.9529450.75) 0.335 (0.2680.402)
 Brunei Darussalam 87921.16 (74080.37101916.11) 31846.23 (26789.4736826.62) 160126.99 (134657.98184712.56) 32250.07 (27198.3237510.49) 0.173 (0.1380.208)
 Burkina Faso 2353001.33 (1919629.322848271.07) 27688.68 (23179.8532535.74) 5972207.66 (4873384.457261041.86) 27771.59 (23468.6133306.19) 0.152 (0.0550.248)
 Burundi 1484747.97 (1213352.691817462.49) 28611.72 (24029.4434242.46) 3743277.56 (3037732.84549754.58) 28842.49 (23929.4734603.44) 0.191 (0.1690.212)
 Cabo Verde 91621.56 (74965.79109487.93) 27740.15 (23379.0432662.95) 167381.07 (141345.61196637.51) 27703.35 (23452.4432246.73) 0.585 (0.5310.639)
 Cameroon 2668507.4 (2183227.433217356.43) 27725.26 (23287.5732511.09) 8780093.53 (7207889.1410367442.44) 27846.1 (23586.3832348.99) 0.209 (0.1940.223)
 Canada 7947702.06 (6632529.639224813.79) 28011.8 (23326.9532426.58) 9747196.16 (8158536.3911263496.62) 27334.54 (22563.7332029.89) −0.344 (−0.388-0.301)
 Central African Republic 730623.7 (603465.96875457.63) 28156.94 (23569.9233087.06) 1522683.98 (1243505.961820600.58) 27728.33 (23069.6332603.99) 0.151 (0.1350.167)
 Chad 1480395.79 (1196652.991784490.89) 27520.36 (22726.6232936.76) 4471803.84 (3669585.455395514.2) 27733.86 (23424.6132588.94) 0.075 (0.0370.113)
 Commonwealth of Dominica 23582.37 (19797.8327686.24) 32292.7 (27430.6937886.75) 22889.68 (19706.9226097.44) 32670.95 (28070.8637298.86) 0.237 (0.2130.261)
 Commonwealth of the Bahamas 87604.79 (74875.48103080.59) 32695.47 (28179.7738048.64) 132689.99 (113758.37154346.03) 32470.58 (27807.9538019.17) 0.143 (0.1040.182)
 Comoros 125159.96 (105862.51146885.78) 26256.95 (22557.2230662.51) 211229.07 (182099.99245226.41) 26495.3 (22996.2430582.58) 0.151 (0.1400.162)
 Congo 660670.34 (541376.27790712.34) 28038.09 (23544.0232816.63) 1570010.64 (1290223.281867089.56) 28131.23 (23354.3633161.16) 0.084 (0.0470.122)
 Cook Islands 5461.48 (4587.756347.62) 27997.03 (23562.7332296.31) 4949.37 (4147.795779.59) 28471.56 (23614.6433374.64) −0.157 (−0.190-0.125)
 Czech Republic 3204634.03 (2761041.323697390.75) 30628.78 (26122.8935363.51) 3276847.41 (2865933.973785509.74) 31921.16 (27630.7536808.72) −0.043 (−0.075-0.011)
 Democratic People's Republic of Korea 2871498.88 (2219972.193574084.68) 13382.92 (10379.4416644.22) 3899100.16 (3051242.634784341.74) 14287.89 (10984.117839.22) 0.098 (0.0560.139)
 Democratic Republic of the Congo 10000978.17 (8200510.5712091105.82) 27857.57 (23305.433141.19) 25204039.15 (20737772.9629993692.42) 27934.03 (23451.8832713.34) 0.421 (0.3060.536)
 Democratic Republic of Timor-Leste 239118.07 (201208.48280687.04) 31721.78 (27127.2836891.56) 459965.25 (397488.48525384.14) 32664.54 (28419.5237183.76) 0.180 (0.1530.207)
 Democratic Socialist Republic of Sri Lanka 5918311.57 (5024365.926801293.92) 33164.31 (28261.3137967.08) 7501673.33 (6414159.28677233.08) 33232.35 (28221.3338482.93) 0.253 (0.1870.320)
 Djibouti 120662.45 (103776.13141300.46) 26541.55 (23107.7230945.8) 357200.44 (306080.37424565.14) 26415.32 (22721.9631213.63) −0.084 (−0.107-0.062)
 Dominican Republic 2312911.26 (1941835.962672356.03) 32152.1 (27392.4536592.96) 3679394.38 (3169522.124277295.26) 32709.88 (28110.1937983.93) −0.098 (−0.132-0.064)
 Eastern Republic of Uruguay 936290.85 (817509.151075544.64) 30061.52 (26087.934719.81) 1025647.71 (884721.851178739.8) 30476.72 (26099.3835227.12) 0.210 (0.1750.245)
 Equatorial Guinea 108772.61 (89164.84130392.14) 27891.19 (23520.4332721.74) 458849.83 (378746.69538847.74) 28194.14 (23710.8532668.99) 0.027 (0.0120.041)
 Eritrea 918308.82 (754359.651102911.6) 28027.38 (23618.833720.55) 1909260.63 (1585629.942256374.33) 28423.32 (23951.4933537.65) 0.486 (0.4510.521)
 Eswatini 185880.56 (150246.41233999.96) 24371.52 (20360.2829141.11) 296794.67 (245478.98359820.11) 24364.45 (20382.5229065.95) 0.210 (0.1940.225)
 Ethiopia 15224397.6 (13552013.1816981688.75) 31155.69 (27902.4634456.76) 35843519.66 (32053289.239939266.81) 31059.37 (28131.0234296.87) 0.374 (0.3430.405)
 Federal Republic of Germany 21846204.2 (19454806.4824349307.16) 28149.89 (25311.3731092.03) 19436721.98 (16852454.2222345344.61) 27588.79 (24063.5332168.3) 0.305 (0.2830.326)
 Federated States of Micronesia 28885.8 (24331.1934033.42) 27623.89 (23371.2132105.1) 29777.39 (24497.4335444.05) 27624.03 (22859.1132844.84) −0.410 (−0.503-0.317)
 Federative Republic of Brazil 55622448.71 (47914093.7163249226.18) 36255.16 (31387.0441183.67) 83268309.12 (72800391.7294037784.77) 36800.64 (32044.0741659.97) 0.114 (0.0950.133)
 French Republic 19451227.8 (17166584.6121932483.9) 33943.56 (30180.3238213.27) 21245929.75 (18657158.2324135470.25) 33660.89 (29093.4338621.45) 0.074 (0.0410.107)
 Gabon 266294.21 (220412.53320262.81) 27909.82 (23389.1732914.41) 528933.62 (438119.03631437.29) 28184.4 (23698.6433324.27) −0.171 (−0.193-0.149)
 Gambia 252487.55 (206866.29305864.11) 27268.32 (22842.6732428.14) 668737.06 (552414.76802217.98) 27676.83 (23135.232615.55) 0.196 (0.1740.218)
 Georgia 1753187.51 (1461364.722038618.08) 31490.85 (26227.3836594.52) 1115648.54 (959293.251301283.51) 32025.61 (27266.9137285.17) 0.210 (0.1820.239)
Ghana 3917104.72 (3279083.684619530.36) 27627.91 (23569.6332101.79) 9607738.12 (7982554.7711491632.42) 27578.61 (23081.2232515.68) −0.132 (−0.169-0.095)
 Grand Duchy of Luxembourg 115672.96 (98946.06134971.1) 30175.19 (25591.9835125.84) 194886.13 (167267.83228561.89) 31012.06 (26160.1736543.24) 0.242 (0.2180.266)
 Greenland 16985.97 (14486.3519612.48) 27392.62 (23079.2231906.72) 15115.49 (12900.8117644.72) 26966.69 (23004.6932115.35) −0.014 (−0.0320.004)
 Grenada 27495.16 (23384.732007.16) 32338.91 (27669.9637622.89) 35260.23 (30375.8540342.99) 33053.76 (28289.5937844.95) −0.264 (−0.334-0.194)
 Guam 40674.28 (33554.9447998.79) 28146.24 (23465.532851.93) 44180.57 (37162.2352740.39) 28418.55 (23807.3734104.6) 0.266 (0.2290.303)
 Guinea 1484638.4 (1228300.621767022.3) 27649.68 (23143.2832385.83) 3567236.83 (2912687.544325936.11) 27654.75 (23166.9532923.18) −0.212 (−0.228-0.196)
 Guinea-Bissau 255211.57 (214910.94308267.12) 26989.75 (23012.1131786.92) 551547 (459912.91663529.42) 26959.49 (22745.9431598.48) 0.206 (0.1790.232)
 Hashemite Kingdom of Jordan 1148770.37 (955835.971367405.56) 30855.61 (26109.3935987.92) 4064311.63 (3398012.434832234.66) 31040.71 (25993.4136640.58) 0.172 (0.1600.185)
 Hellenic Republic 3058998.56 (2688705.553543380.94) 29487.78 (25872.2234016.81) 2909713.37 (2505876.243370947.09) 31085.17 (26279.6536426.44) 0.264 (0.2510.276)
 Hungary 3288087.22 (2819994.713798093.85) 31216.77 (26539.0835920.15) 2994481.97 (2597892.853399228.76) 32283.09 (27576.5136819.86) −0.256 (−0.326-0.186)
 Independent State of Papua New Guinea 1144159.07 (947010.041399831.7) 27572.63 (23074.0333242.6) 2930414.22 (2387971.223507873.94) 27559.04 (22619.7332759.11) −0.012 (−0.0460.022)
 Independent State of Samoa 47680.49 (39722.3756944.51) 27825.4 (23505.9933025.62) 59403.23 (49705.1370636.01) 27845.34 (23493.532982.09) 0.031 (0.0020.060)
 India 266713865.12 (230196534.76304917223.81) 31361.98 (27439.2335573.34) 484909328.35 (430904507.85541892748.56) 32009.86 (28378.8935843.75) −0.055 (−0.066-0.043)
 Ireland 1118880.8 (966283.41309207.36) 30482.86 (26259.3535772.7) 1487803.61 (1276791.851734046.47) 31181.63 (26470.2236483.36) 0.146 (−0.0010.294)
 Islamic Republic of Iran 19352960.76 (17046984.3821678995.86) 34459.88 (30709.0838071.63) 30519541.68 (27273820.7533924033.99) 34568.83 (30959.8938333.71) −0.214 (−0.251-0.177)
 Ivoire 3177265.68 (2601327.523811974.17) 27633.65 (23218.8832664.11) 7571579.51 (6213044.748895117.55) 27521.13 (22957.2731770.96) 0.075 (−0.0060.155)
 Jamaica 768982.72 (639788.67902222.03) 31978.14 (26998.5337255.61) 962352.12 (829459.751119478.24) 32712.95 (27986.4238422.99) 0.236 (0.2150.257)
 Japan 38066101.68 (33777811.9742635469.41) 29746.37 (26250.9933760.38) 26156578.48 (23265025.9129385561.27) 24611.78 (21570.2927745.67) −1.269 (−1.401-1.137)
 Kenya 6819762.84 (5876207.637786892.82) 30397.39 (26716.4634028.7) 15873136.05 (13790474.217725760.14) 29713.7 (26235.5133101.45) 0.217 (0.1980.236)
 Kingdom of Bahrain 169896.06 (141009.88205442.27) 31357.5 (26571.8736761.06) 532755.7 (446007.15623326.14) 31822.09 (26593.1936899.86) 0.211 (0.1350.287)
 Kingdom of Belgium 2747619.57 (2345112.893190088.63) 27651.49 (23492.5932703.79) 3047106.07 (2503213.993508826.42) 28396.83 (23337.9233393.95) −0.158 (−0.253-0.063)
 Kingdom of Cambodia 3511163.93 (2999251.854009486.52) 36364.14 (31815.5740885.08) 6578429.91 (5666830.797489903.51) 37688.44 (32668.0542766.89) 0.538 (0.4870.589)
 Kingdom of Denmark 1175668.71 (1034362.441343971.73) 23265.07 (20604.9826593.97) 1259976.21 (1085596.481446002.11) 24983.51 (21445.129015.02) −0.198 (−0.234-0.161)
 Kingdom of Norway 1400389.01 (1232305.161571346.48) 32821.54 (28727.4637010.74) 1750672.17 (1558122.451963645.15) 33319.43 (29265.2937375.24) −0.090 (−0.117-0.062)
 Kingdom of Spain 12328055.89 (10914990.3313970173.98) 31368.85 (27726.5635529.25) 13662220.41 (11767038.8715861487.44) 32142.49 (27146.1437244.91) −0.300 (−0.355-0.245)
 Kingdom of Sweden 2155780.45 (1810616.292547482) 26144.96 (21761.7831283.04) 2824211.62 (2421196.443262886.64) 29425.05 (24847.3734210.06) 0.330 (0.2220.438)
 Kingdom of Thailand 19916003.34 (16829561.5622901851.75) 32790.45 (27888.8337598.73) 22612897.21 (19570840.2226101296.77) 33760.98 (29048.3739156.15) −0.158 (−0.196-0.120)
 Kingdom of the Netherlands 4157070.71 (3692981.324653671.14) 27668.69 (24486.730759.4) 3703841.36 (3196697.384226220.7) 25301.26 (21661.4629195.9) −0.557 (−0.692-0.422)
 Kingdom of Tonga 27412.79 (22766.2832762.05) 27822 (23159.5332432.31) 29299.08 (24596.134530.69) 27816.31 (23428.932972.43) −0.066 (−0.092-0.040)
 Kyrgyz Republic 1382109.52 (1174132.581593735.55) 31479.27 (27048.436006.41) 2182136.29 (1869887.992541266.64) 31706.85 (27311.1336709.15) 0.063 (0.0030.124)
 Lao People's Democratic Republic 1303807.17 (1089189.61516515.11) 33067.25 (27951.8937939.27) 2568697.01 (2181480.892921028.21) 33588.75 (28606.5738143.53) 0.441 (0.3990.482)
 Lebanon 913016.34 (761538.051063074.13) 30781.42 (25985.1436011.85) 1796409.43 (1531250.662081991.27) 31342.16 (26850.936008.68) 0.248 (0.2230.274)
 Lesotho 349820.57 (287263.04424975.75) 24368.09 (20560.2628778.68) 485753.91 (401021.76580015.59) 24290.52 (20204.1728917.64) 0.401 (0.3760.427)
 Liberia 623028.1 (510809.01746374.44) 27380.5 (22700.9232264.59) 1529982.76 (1261544.061820309.69) 27569.91 (23104.9332200.89) 0.367 (0.3430.390)
 Libya 1305307 (1088368.841521310.21) 31086.02 (26699.4335869.88) 2337662.79 (1963190.22725901.37) 31649.45 (26568.9836897.99) 0.310 (0.2490.371)
 Madagascar 3311551.81 (2811304.373882880.66) 29479.37 (25014.1834419.31) 8980779.39 (7605552.9510558753.07) 31305.71 (26756.8236327.56) 0.327 (0.2990.355)
 Malawi 2662413.9 (2190407.553223735.13) 28771.95 (24322.6933814.52) 5717621.41 (4650664.116956265.98) 28782.99 (23960.334497.44) 0.217 (0.1620.273)
 Malaysia 4594387.71 (3783262.325610186.23) 25273.73 (21069.2430257.86) 8638384.47 (7017142.5810181957.6) 25382.12 (20531.6130047.15) 0.130 (−0.0210.281)
 Mali 2128954.49 (1756953.712575139.71) 27389.91 (23222.8432516.49) 6201379.79 (5036257.317451890.76) 27562.92 (22958.7832905.6) 0.137 (0.1050.170)
 Mauritania 529028.42 (433794.35640298.99) 27503.27 (22980.4932775.56) 1197652.46 (992462.851414648.59) 27756.38 (23419.1332489.46) 0.115 (0.0920.138)
 Mauritius 385233.94 (327883.71446559.38) 33161.31 (28585.4238094.83) 439354.69 (379786.19501088.46) 33697 (28770.338594.57) −0.025 (−0.037-0.012)
 Monaco 8769.24 (7578.510163.5) 30686.64 (25869.8935836.18) 10556 (9003.6911982.22) 31383.52 (26562.7536085.59) −0.130 (−0.167-0.094)
 Mongolia 669564.87 (548231.31785597.42) 31305.01 (26109.2936521.8) 1057824.91 (902523.151231575.05) 32104.62 (27665.5337063.08) 0.017 (−0.0880.123)
 Montenegro 189235.88 (162906.31218197.17) 29708.99 (25460.5734160.29) 190697.88 (165218.26219835.88) 31119.24 (26762.1436008.35) 0.072 (0.0590.084)
 Morocco 8716241.67 (7589393.899961115.58) 33060.97 (28510.8437626.76) 12407219.25 (10776584.4914031553.81) 32602.52 (28310.6736905.12) −0.278 (−0.395-0.161)
 Mozambique 3153326.56 (2640089.393785016.25) 24918.57 (21372.3429414.04) 8678734.99 (7089820.3910506989.19) 28609.71 (23998.9733647.09) 0.289 (0.2060.371)
 Namibia 314511.25 (261630.6381157.12) 23111.19 (19580.4927401.26) 632392.6 (518430.34763331.83) 24771.71 (20519.0629617.91) 0.373 (0.2850.461)
 Nauru 2858.41 (2360.863386.95) 28004.03 (23436.0333002.38) 3196.61 (2675.833772.17) 27866.49 (23428.3532793.45) 0.063 (0.0420.083)
 Nepal 4902367.16 (4030975.885852668.16) 26629.29 (22255.3631270.27) 8810104.66 (7288335.1410423696.55) 26643.43 (22092.5731209.58) 0.429 (0.2340.625)
 New Zealand 1091830.31 (955407.31255061.86) 30593.14 (26678.6135362.43) 1650286.06 (1397743.261906860.74) 31968.69 (26947.3337198.46) −0.032 (−0.1150.051)
 Niger 1957451.61 (1598293.62349758.92) 27272.85 (22678.3431888.83) 6261403.89 (5057765.167627672.58) 27316.12 (22874.2532455.9) 0.015 (−0.0310.061)
 Nigeria 25679303.84 (22691862.828842851.05) 29706.48 (26394.3733076.78) 65985199.02 (58136117.4373870823.83) 28644.91 (25650.8231666.74) −0.064 (−0.110-0.018)
 Niue 634.14 (527.26743.79) 27734.95 (23253.7832442.53) 465.94 (390.17535.22) 28206.85 (23484.4532501.16) −0.033 (−0.056-0.010)
 North Macedonia 610599.73 (527270.56704757.19) 30084.09 (26069.6534661.99) 689104.52 (589359.43797956.41) 31521.72 (26989.9635904.57) 0.159 (0.1110.206)
 Northern Mariana Islands 14097.3 (11785.9716494.58) 28426.98 (23714.6132743.08) 13749.34 (11550.5616096.96) 28228.77 (23586.1533055.92) −0.319 (−0.383-0.255)
 Oman 603150.82 (495967.44712963.19) 30733.05 (25873.2735481.45) 1583028.21 (1333455.51891090.15) 31271.05 (26250.236177.28) 0.504 (0.4060.602)
 Pakistan 33156359.87 (28085047.5838280272.94) 31691.42 (27235.0235889.96) 75243546.86 (63778687.7587016245.14) 31147 (26629.4535636.6) 0.221 (0.1980.245)
 Palau 4518.59 (3793.735316.77) 27809.41 (23531.5732679.44) 5039.87 (4278.185964.98) 28105.55 (23829.9133537.81) −0.239 (−0.294-0.185)
 Palestine 603793.58 (497900.52714586.55) 31170.7 (26731.9235703.14) 1685974.11 (1418807.061955010.01) 31609.81 (27043.6936256.99) 0.413 (0.3770.449)
 People's Democratic Republic of Algeria 7777477.75 (6405395.289163313.62) 30825.79 (25722.736062.14) 13914734.83 (11516606.6816284615.53) 31325.11 (26088.9636455.89) 0.035 (−0.0620.133)
 People's Republic of China 230901904.01 (190042711.77278380603.17) 17990.76 (14777.3821629.84) 316752689.04 (276805596.9366305223.18) 23759.62 (20403.0627675.83) 0.802 (0.4331.173)
 Plurinational State of Bolivia 1854145.52 (1575044.282188171.03) 29764.56 (25361.0735167.59) 3640595.62 (3102812.424303462.99) 30093.41 (25729.6435485.99) 0.228 (0.2040.251)
 Portuguese Republic 3059381.61 (2564480.273585697.99) 29552.68 (24702.4134700.24) 3007830.08 (2497404.583477387.61) 30587.65 (25298.135711.41) −0.379 (−0.425-0.332)
 Principality of Andorra 17945.41 (15130.1220805.25) 30496.01 (25450.4235383.71) 25458.83 (21948.1829965.14) 30896.3 (26348.5136424.36) −0.387 (−0.438-0.336)
 Puerto Rico 1205146.57 (1024567.321391821.37) 32611.66 (27708.3437629.17) 1103556.7 (942536.251271475.29) 33173.58 (28194.4638311.65) 0.049 (0.0300.069)
 Qatar 149928.62 (123970.27175164.97) 31122.66 (26255.435598.34) 1095125.59 (909613.361284266.55) 32265.01 (27272.4536774.77) 0.464 (0.3780.550)
 Republic of Albania 1008127.85 (846091.011186275.62) 30168.18 (25534.234964.12) 841279 (720029.13968538.33) 31548.76 (26745.5436166.1) 0.224 (0.1740.274)
 Republic of Armenia 1083348.55 (905529.731261824.69) 31439.57 (26497.1636405.42) 944991.75 (816947.291107637.19) 31738.77 (27266.5236953.28) −0.017 (−0.0700.037)
 Republic of Austria 2309680.22 (1984491.282684425.11) 29246.57 (24740.2234171.79) 2575008.97 (2201577.752968216.95) 30292.98 (25554.0735239.63) −0.170 (−0.192-0.148)
 Republic of Azerbaijan 2336261.48 (1991397.952681465.59) 31445.6 (26893.5635962.59) 3478201.24 (2956852.934066262.7) 32142.44 (27262.4337206.91) 0.133 (0.0750.191)
 Republic of Belarus 3275408.58 (2779976.313773131.85) 31380.05 (26593.3336066.36) 2824281.02 (2393036.723267973.98) 31503.49 (26713.7836311.45) −0.134 (−0.208-0.061)
 Republic of Bulgaria 2928044.01 (2542544.063355707.23) 33671.5 (29258.7938560.45) 2273668.05 (1988200.332601408.3) 33937.11 (29324.7638714.16) 0.003 (−0.0070.013)
 Republic of Chile 4109395.73 (3425440.914773406.69) 29894.63 (24964.3534634.65) 5616266.99 (5022867.486190892.39) 29833.67 (26155.0133092.35) 0.071 (−0.2100.354)
 Republic of Colombia 9070987.22 (7358920.3211138553.81) 26857.62 (22152.232667.66) 14136966.09 (12011536.7916525363.57) 27631.87 (23281.0132599.97) −0.311 (−0.488-0.134)
 Republic of Costa Rica 958089.45 (803849.861126201.45) 31151.01 (26581.1635969.12) 1573332.58 (1335948.921849874.8) 31975.92 (27006.0237465.32) 0.161 (0.1170.205)
 Republic of Croatia 1460832.69 (1245283.351717696.5) 29623.87 (25297.5534782.18) 1269434.53 (1106288.721454610.61) 30987.55 (26747.7135581.31) 0.056 (0.0320.080)
 Republic of Cuba 3696107.42 (3153610.164336902.22) 32489.58 (27709.237842.18) 3713684.07 (3190703.594284971.47) 32981.35 (28087.2237873.2) −0.214 (−0.276-0.152)
 Republic of Cyprus 239459.94 (201844.32278844.72) 30110.07 (25375.4835101.11) 413323.73 (356044.52482503.29) 30897.25 (26296.2536171.3) −0.030 (−0.0970.036)
 Republic of Ecuador 3027345.14 (2536051.473508925.03) 30149.75 (25549.6634856.56) 5636070.92 (4850071.776501067.22) 30459.22 (26209.8834986.07) 0.255 (0.1890.322)
 Republic of El Salvador 1650242.03 (1369927.261955997.34) 31317.54 (26348.1937215.38) 2088731.07 (1775734.712428479.93) 31578.38 (26852.7636664.82) 0.240 (0.2000.281)
 Republic of Estonia 428004.36 (359072.52499433.52) 27676.71 (23048.932356.65) 329465.56 (273028.25392189.06) 27381.02 (22539.4433017.33) −0.294 (−0.364-0.223)
 Republic of Fiji 219999.23 (182663.73259751.3) 27695.67 (23399.3432563.97) 265503.92 (221332.11309514.46) 28225.06 (23586.3832885.13) −0.161 (−0.232-0.090)
 Republic of Finland 1083589.56 (906183.191282417.74) 21995.52 (18381.8326570.47) 1130872.4 (942475.291338122.63) 22482.22 (18513.5927495.03) −0.182 (−0.6420.280)
 Republic of Guatemala 2452690.43 (2012272.812900153.15) 31209.94 (26325.7336535.05) 5234107.42 (4475359.876203651.59) 31651.47 (27086.9737308.21) 0.479 (0.4540.504)
 Republic of Guyana 250083.79 (209677.16290310.84) 31955.98 (27196.1736740.56) 255275.27 (218081.66294664.37) 32621.35 (27993.0537435.61) 0.242 (0.2030.280)
 Republic of Haiti 1974720.03 (1733779.142202272.53) 31589.43 (28260.835016.96) 4221135.77 (3692253.254835259.94) 31187.35 (27244.0135578.22) 0.200 (0.1610.239)
 Republic of Honduras 1386494.63 (1151924.941661631.39) 30829.29 (26164.2336355.25) 3334744.48 (2821515.173883701.73) 31582.85 (26893.6936917) 0.400 (0.3800.420)
 Republic of Iceland 73774.07 (66108.7482007.35) 28543.58 (25565.1231735.24) 85180.57 (74131.7898445.6) 26499.7 (23133.5230847) −0.143 (−0.2970.011)
 Republic of Indonesia 69024636.88 (59439925.0478379172.53) 36621.33 (31825.8441414.33) 107767679.63 (94432770.18121309355.75) 36825.74 (32315.2341419.18) 0.180 (0.0600.300)
 Republic of Iraq 5512863.44 (4524564.056433895.56) 30818 (26136.2935436.83) 13602079.84 (11457848.9415845831.29) 31601.14 (26878.3636770.81) 0.307 (0.2980.315)
 Republic of Italy 17706161.96 (15305815.0220094211.98) 30791.09 (26279.5135201.41) 16367600.53 (14327238.6518610818.91) 30602.88 (26501.934852.53) −0.453 (−0.481-0.426)
 Republic of Kazakhstan 5213989.95 (4424475.266030655.84) 31531.99 (2687136312.48) 6061566.41 (5125557.796994183.69) 32382.07 (27538.2637453.63) −0.045 (−0.1080.017)
 Republic of Kiribati 20505.57 (16860.7424490.3) 27374.94 (22532.9132442.11) 34688.88 (28946.1540364.97) 27723.2 (23220.7432076.91) 0.134 (0.1060.162)
 Republic of Korea 17870168.38 (15420466.9320283927.31) 36782.38 (31485.6742269.31) 18998165.21 (16684044.6921390853.31) 36406.89 (31923.0940694.05) −0.413 (−0.459-0.368)
 Republic of Latvia 829515.61 (709894.68958407.65) 31595.8 (26694.4136456.51) 554201.16 (473681.75645410.41) 31760.33 (26795.9436881.28) −0.193 (−0.256-0.131)
 Republic of Lithuania 1213471.16 (1068590.961389471.69) 32789.73 (28843.3837392.46) 878306.44 (760351.2995501.56) 33525.8 (28574.2338377.64) −0.042 (−0.079-0.005)
 Republic of Maldives 68414.81 (56751.2279830.02) 33130.99 (28254.1938153.86) 195580.93 (167496.72226946.32) 33896.63 (29174.5138648.99) 0.704 (0.6360.773)
 Republic of Malta 113056.8 (96297.32131493.13) 30381.81 (25698.5935417.73) 126697.28 (110085.71147364.52) 30934.31 (2613835641.65) −0.180 (−0.234-0.126)
 Republic of Moldova 1406429.08 (1204241.341588824.96) 31589.29 (27008.2535800.8) 1112648.27 (955538.281287854.79) 31414.11 (26436.6436314.8) −0.055 (−0.1270.016)
 Republic of Nicaragua 1162699.18 (959004.81379552.91) 30926.16 (26309.1535873.79) 2193810.89 (1878757.662553062.85) 31619.31 (27173.7836618.81) 0.322 (0.2750.370)
 Republic of Panama 759930.99 (656481.96868095.32) 31294.21 (27293.8835723.91) 1428495.1 (1235389.851663567.75) 32741.92 (28321.1838133.81) 0.153 (0.1290.176)
 Republic of Paraguay 1179457.46 (979168.111371128.68) 29656.23 (25046.2634540.13) 2146135.32 (1827127.312552016.54) 28899.44 (24559.6734322.04) 0.045 (0.0050.085)
 Republic of Peru 6540867.69 (5575962.497706120.83) 30094.83 (25729.5535169.74) 11335356.14 (9744707.1513339124.97) 30517.88 (26267.4735728.82) 0.145 (0.1110.179)
 Republic of Poland 12473258.03 (11116408.3813769344.33) 32462.59 (28887.1635860.96) 12299827.23 (11057006.5913544723.53) 33484.03 (29867.1136910.99) −0.104 (−0.182-0.026)
 Republic of Serbia 2684620.58 (2319666.983115914.4) 27723.99 (23884.7132306.6) 2497131.31 (2161235.262871832.73) 28302.71 (24378.7932441.22) −0.321 (−0.576-0.065)
 Republic of Singapore 1131972.07 (980691.951291699.17) 32658.01 (27963.4137575.25) 1840224.62 (1541725.692143658.34) 32333.86 (27692.6737440.22) −0.427 (−0.528-0.326)
 Republic of Slovenia 689555.42 (603597.41791210.48) 34366.61 (29989.3439377.36) 685551.58 (596104.4783826.41) 34224.12 (29377.5139119.92) −0.297 (−0.335-0.258)
 Republic of Suriname 130628 (110086.23152059.99) 32968.59 (27839.4438421.37) 195494.86 (165848.15225692) 33092.67 (27936.0838381.85) −0.018 (−0.0490.012)
 Republic of Tajikistan 1623948.55 (1364186.211914453.93) 31577.83 (27004.6436814.03) 3222949.25 (2731911.643789664.09) 31728.06 (27169.337076.45) 0.190 (0.1310.249)
 Republic of the Marshall Islands 12555.85 (10462.314807.39) 27344.9 (23272.9531888.72) 16449.88 (13559.2719606.63) 27841.88 (23002.4932855.71) 0.101 (0.0740.129)
 Republic of the Philippines 21869119.27 (19432791.9724400337.27) 34650.45 (30935.0138343.35) 41405638.36 (37247842.1145526593.31) 35100.14 (31652.9338527.56) 0.187 (0.1540.220)
 Republic of the Union of Myanmar 13714211.27 (11678252.9115825498.51) 33310.87 (28776.1138331.15) 18982011.63 (16203214.1721702764.93) 32608.33 (27817.2437380.08) −0.033 (−0.060-0.007)
 Republic of Trinidad and Tobago 395948.29 (333888.38471815.15) 32443.48 (27645.4338650.7) 424420.84 (368660.03487499.15) 31570.36 (27609.2336288.4) −0.309 (−0.392-0.227)
 Republic of Uzbekistan 6408200.95 (5375370.47511634.52) 31354.24 (26633.836259.71) 10849931.57 (9231416.8912648953.49) 31694.2 (26909.836683.25) 0.166 (0.0790.253)
 Republic of Vanuatu 41506.32 (34263.5949442.96) 27646.59 (23472.3632504.47) 88800.99 (73269.85103913.4) 27825.41 (23075.8632378.55) 0.080 (0.0630.096)
 Romania 7025872.08 (6099490.848006292.06) 29678.76 (25713.933793.72) 5979317.12 (5242909.126935070.21) 32151.46 (27999.2137419.26) 0.134 (0.0790.190)
 Russian Federation 52019682 (45393179.1458730759.82) 34232.02 (29684.4938541.98) 47825366.96 (42266098.2653785609.39) 33962.8 (29717.0138227.61) −0.222 (−0.285-0.158)
 Rwanda 1946684.76 (1557669.522361870.36) 28739.63 (24046.8433978.46) 3904275.07 (3198235.624662444.65) 28741.37 (23924.9933724.24) 0.298 (0.2710.325)
 Saint Kitts and Nevis 13694.83 (11540.7216255.88) 32640.94 (27724.9538790.97) 20268.48 (17327.5623117.52) 33224.26 (28239.2438060.46) 0.224 (0.1880.260)
 Saint Lucia 44669.17 (37544.1851922.09) 32474.07 (27708.9137737.03) 60212.38 (52581.7868444.07) 32860.22 (28480.737574.98) 0.173 (0.1330.212)
 Saint Vincent and the Grenadines 32555.48 (27937.8838006.74) 29654.92 (25673.5334635.07) 37428.91 (32507.142934.77) 32049.77 (27817.7536854.39) 0.387 (0.2960.477)
 San Marino 7449.41 (6403.698586.42) 30311.63 (25668.5735126.05) 9459.23 (8046.9910956.76) 31081.01 (26047.5736536.12) −0.365 (−0.401-0.328)
 Sao Tome and Principe 30795.07 (25216.5136926.65) 27229.82 (22983.2231514.47) 62569.55 (52162.6774035.07) 27770.95 (23554.5432371.28) 0.377 (0.3460.407)
 Saudi Arabia 5475920.23 (4628305.296337458.9) 35001.73 (3031940209.59) 14713356.34 (12474552.4916926529.87) 35861.51 (30967.7740787.9) 0.484 (0.4340.535)
 Senegal 2035156.3 (1734154.662406074.51) 26711.79 (22975.3931080.68) 4544657.14 (3933658.345322331.55) 26660.95 (22964.9931266.54) 0.168 (0.1410.195)
 Seychelles 25027.29 (21280.7728998.33) 33536.72 (28864.838901.77) 36272.36 (31437.3840903.92) 33817.03 (29422.8838266.09) 0.028 (−0.0340.089)
 Sierra Leone 1028906.35 (921936.261161823.25) 25781.1 (23124.5428837.52) 2596485.06 (2256907.862997750.72) 27100.39 (23629.1230966.53) 0.606 (0.5470.664)
 Slovak Republic 1653935.19 (1414261.641900027.26) 30765.53 (26247.8335339.27) 1680813.38 (1455510.391954794.92) 31688.69 (27266.6636557.75) −0.001 (−0.0550.053)
 Socialist Republic of Viet Nam 22580238.11 (18945522.6526075279.35) 33289.72 (28132.6238190.38) 34181345.29 (29040885.5139761757.05) 33401.19 (28354.5738688.23) 0.107 (−0.0200.235)
 Solomon Islands 92404.58 (77475.69109892.79) 27471.98 (23230.1932471.03) 191311.82 (159641.83227931.54) 27421.74 (23044.1232699.62) 0.085 (0.0780.092)
 Somalia 2122520.42 (1719222.52562702.68) 28507.22 (23826.6433861.49) 5852212.47 (4756692.857056014.96) 28263.45 (2354633845.18) 0.038 (0.0190.057)
 South Africa 10536888.13 (9152702.3912128284.36) 27589.07 (24161.5231551.82) 17443557.27 (15311180.6719774380.92) 29034.48 (25457.7432894.36) 0.297 (0.2320.362)
 South Sudan 1648795.96 (1364334.481991741.08) 29067.24 (24499.0134374.86) 2724455.41 (2236933.663234913.68) 29042.18 (24351.233865.87) 0.005 (−0.0150.025)
 State of Israel 1634819.11 (14070221901185.53) 32738.56 (28185.2538062.85) 3171581.52 (2770062.373626685.1) 33877.63 (29544.7138748.98) −0.020 (−0.0570.017)
 State of Kuwait 578056.3 (479851.15673906.11) 31509.41 (26607.4736088.13) 1607959.27 (1342757.461882523.68) 31797.6 (26504.2537121.99) 0.136 (0.1040.168)
 Sudan 5865801.44 (4831870.16800745.28) 30371.67 (25605.6135384.99) 13931925.33 (11675920.3116180918.72) 31217.21 (26434.5935943.47) 0.285 (0.2570.314)
 Swiss Confederation 2007998.04 (1702018.412340713.89) 29534.29 (25451.8134175.39) 2591728.93 (2250515.582923965.54) 30926.73 (26745.2735184.92) −0.028 (−0.0810.026)
 Syrian Arab Republic 3777845.42 (3113168.554443860.97) 30581.68 (26040.735366.16) 4439559.94 (3772417.335203006.85) 30867.99 (26251.6336053.93) 0.254 (0.1990.310)
 Taiwan (Province of China) 3028395.49 (2380864.913798365.39) 13545.75 (10638.6216938.92) 3040921.68 (2428448.993633126.85) 13329.27 (10258.6316272.28) −0.332 (−0.416-0.248)
 Togo 976939.6 (857099.131112905.63) 27408.43 (24347.9530903.61) 2380170.22 (2081368.832769313.62) 26758.76 (23492.6130861.31) 0.102 (0.0770.126)
 Tokelau 438.02 (365.02515.41) 27578.01 (23166.3632321.56) 390.65 (326.5453.51) 27893.45 (23297.5632488.83) 0.087 (0.0560.119)
 Tunisia 2578877.08 (2153380.083015282.41) 30422.05 (25551.7735454.39) 3729260.52 (3217271.24240119.15) 31266.58 (26957.6335629.54) 0.027 (−0.0420.096)
 Turkey 17998399.43 (1509357821281515.79) 30670.22 (25956.4836152.45) 26849705.36 (22637078.730838309.84) 31286.85 (26240.0236020.46) 0.125 (0.0810.170)
 Turkmenistan 1133277.63 (954973.341335776.3) 31072.56 (26578.2935974.49) 1687631.25 (1441059.141914439.37) 32238.97 (27706.6136584.77) 0.206 (0.1700.243)
 Tuvalu 2555.18 (2136.813011.8) 27780.93 (23257.7132669.04) 3493.16 (2917.644181.1) 27614.75 (23053.3232795.58) 0.168 (0.1470.190)
 Uganda 4549959.19 (3731489.025603133.84) 28946.61 (24173.7933896.32) 12075380.54 (9768794.9214800844.05) 28906.15 (23808.6834463.86) 0.188 (0.1370.239)
 Ukraine 18012711.28 (15663677.8520686385.24) 34218.8 (29644.0739319.49) 14490003.51 (12610643.9116420587.51) 34097.11 (29311.0738751.83) −0.078 (−0.150-0.007)
 United Arab Emirates 636124.4 (528140.69751469.52) 31712.78 (26681.0236844.45) 3199827.79 (2644240.043866375.61) 31432.54 (26620.2636584.71) 0.134 (−0.0740.343)
 United Kingdom of Great Britain and Northern Ireland 18004745.9 (16092139.1820006300.21) 31921.11 (28444.0835529.57) 20389092.54 (18474169.5822436033.9) 32000.49 (28730.2235382.81) −0.137 (−0.158-0.117)
 United Mexican States 27076842.15 (22825282.5331385284.53) 31035.09 (26594.8535305.88) 40931982.67 (35415668.0346383946.61) 30231.54 (26119.2434396.02) −0.023 (−0.0620.017)
 United Republic of Tanzania 4987540.12 (4195489.796013410.34) 21113.39 (17963.7925266.55) 13619612.1 (10857183.4917128633.21) 23097.07 (18919.6728281.79) 0.152 (−0.0160.321)
United States of America 83748055.96 (73482646.8693841115.29) 32268.24 (28022.736310.08) 101507986.65 (89016022.09114045089.76) 31288.5 (27299.1235234.37) −0.147 (−0.243-0.051)
 United States Virgin Islands 35118.15 (30104.9340361.58) 32901.14 (28179.6237864.49) 28060.47 (24296.7531882.05) 33397.41 (28520.9837981.15) 0.029 (0.0060.051)
 Yemen 3388811.38 (2650506.824132489.6) 26633.22 (21810.8932488.95) 9396526.68 (7453457.6311445659.96) 27264.43 (22389.9332435.34) 0.522 (0.3150.729)
 Zambia 2171056.94 (1864487.982505523.46) 26284.79 (22807.7530305.41) 5653750.83 (4846226.976677009.55) 26607.99 (23131.6130968.93) 0.149 (0.1180.181)
 Zimbabwe 2395501.11 (1942660.772990960.13) 24042.32 (20126.2428729.55) 3730601.17 (3092410.934553541.82) 23749.74 (19829.7328432.77) 0.032 (−0.0170.080)

Table 2.

The number of prevalence cases and the age-standardized prevalence rate attributable to caries of permanent teeth in 1990 and 2021 and its trends from 1990 to 2021 globally

Number of prevalence cases (95% UI) in 1990 The age-standardized prevalence rate/100000 (95% UI) in 1990 Number of prevalence cases (95% UI) in 2021 The age-standardized prevalence rate/100000 (95% UI) in 2021 EAPC (95% CI)
Global 1466379652 (1255303081–1731120376) 28331.49 (24315.34–33176.93) 2242874758 (1957579677–2599622169) 27543.34 (23976–32018.09) −0.03 (−0.09–0.02)
Sex
 Female 739208373 (635939946–870333401) 28608.32 (24676.38–33424.08) 1131593062 (987306930–1307857024) 27791.06 (24168.74–32248.26) −0.04 (−0.09–0.02)
 Male 727171279 (618718834–861119940) 28074.42 (24020.35–32950.07) 1111281696 (969787614–1294372241) 27300.85 (23802.34–31795.78) −0.03 (−0.09–0.02)
Age
 5–9 years 55416038 (28021830–93384444) 9496.68 (4802.12–16003.35) 55379924 (27717494–92230407) 8060.5 (4034.26–13424.05) −0.31 (−0.41–0.21)
 10–14 years 140958095 (89958536–202288610) 26313.73 (16793.25–37762.77) 159921741 (104132819–227775562) 23989.37 (15620.64–34167.91) −0.17 (−0.25–0.1)
 15–19 years 159711515 (107820398–224195102) 30747.84 (20757.71–43162.3) 191675831 (133141672–261959958) 30718.27 (21337.49–41982.12) 0.06 (−0.01–0.13)
 20–24 years 193867942 (139170619–253450448) 39397.01 (28281.66–51505.12) 227158647 (171124875–291991568) 38039.95 (28656.54–48896.86) −0.1 (−0.14–0.06)
 25–29 years 168638646 (117310984–243886546) 38100.13 (26503.79–55100.7) 222643418 (163275553–312496950) 37842.44 (27751.75–53114.74) 0.03 (−0.03–0.09)
 30–34 years 136863076 (99229572–193310540) 35509.88 (25745.66–50155.49) 212736036 (157293774–292579430) 35193.22 (26021.33–48401.82) 0.08 (0.01–0.15)
 35–39 years 125051896 (81023358–171405486) 35501.45 (23002.02–48660.94) 203269766 (138829361–272800884) 36242.12 (24752.67–48639.22) 0.1 (0.06–0.14)
 40–44 years 102668400 (67696732–139434387) 35837.69 (23630.39–48671.32) 182511550 (124569447–245436967) 36484.01 (24901.4–49062.78) 0.05 (0–0.1)
 45–49 years 82854572 (57720108–110221346) 35683.11 (24858.41–47469.2) 166093147 (117776761–218822172) 35077.41 (24873.41–46213.31) −0.03 (−0.1–0.04)
 50–54 years 75486159 (48573311–101360977) 35510.96 (22850.34–47683.25) 150592841 (101561982–201238711) 33846.95 (22826.87–45230.01) −0.08 (−0.14–0.02)
 55–59 years 64686143 (44785636–86993622) 34927.73 (24182.31–46972.81) 131690603 (93240164–175095035) 33278.06 (23561.68–44246.31) −0.09 (−0.13–0.05)
 60–64 years 55693880 (41859014–73643584) 34676.64 (26062.64–45852.65) 107647898 (81097596–141060948) 33634.94 (25339.21–44074.96) −0.12 (−0.16–0.07)
 65–69 years 42235053 (31580269–52514909) 34168.14 (25548.42–42484.54) 89463085 (67985743–110428254) 32432.71 (24646.61–40033.13) −0.13 (−0.19–0.07)
 70–74 years 28042675 (19438484–35155855) 33123.43 (22960.33–41525.37) 65332724 (47108018–81027531) 31739.69 (22885.83–39364.48) −0.09 (−0.14–0.03)
 75–79 years 19114009 (14447893–24105659) 31051.66 (23471.32–39160.84) 38820745 (30584007–48419386) 29435.43 (23190.01–36713.5) −0.09 (−0.14–0.03)
 80–84 years 10185393 (7226910–13528889) 28791.88 (20428.89–38243.21) 23307466 (16985304–30296495) 26611.84 (19393.37–34591.73) −0.15 (−0.2–0.1)
 85–89 years 3851605 (2582027–5308873) 25488.63 (17086.99–35132.34) 10523631 (7255281–14034347) 23016.66 (15868.32–30695.1) −0.26 (−0.3–0.22)
 90–94 years 902099 (533970–1334568) 21051.57 (12460.82–31143.74) 3372581 (2115080–4791980) 18852.43 (11823.11–26786.74) −0.34 (−0.4–0.28)
 95 + years 152456 (85501–238909) 14974.78 (8398.16–23466.51) 733124 (439842–1108716) 13451.05 (8070.03–20342.27) −0.27 (−0.39–0.15)
SDI region
 High-middle SDI 310012322 (261811414–366835272) 28281.67 (24070.1–33146.27) 379284830 (328955920–436467219) 26691.98 (23040.41–31381.8) −0.2 (−0.21–0.18)
 High SDI 237447100 (207466051–273319204) 25313.92 (22122.01–29368.4) 278799405 (248570842–314093138) 23472.19 (20786.3–26991.46) −0.22 (−0.27–0.17)
 Low-middle SDI 321852938 (272830206–382011614) 31661.78 (27493.71–36853.24) 566930051 (488469072–668027835) 29891.17 (25921.28–34837.22) −0.06 (−0.17–0.06)
 Low SDI 136548862 (117999590–157470597) 33092.46 (29245.6–37734.65) 310714532 (267852988–360694838) 31719.14 (27960.28–36261.48) −0.1 (−0.16–0.04)
 Middle SDI 458696797 (384654425–549466408) 27336.24 (23133–32332.31) 704937398 (607791505–824675289) 27257.52 (23565–31966.2) 0.06 (−0.01–0.13)
GBD region
 Advanced Health System 404607923 (353344981–465780912) 29023.38 (25368.27–33549.78) 450153393 (399506202–508283296) 26974.56 (23784.11–30944.28) −0.23 (−0.25–0.2)
 Africa 165668688 (141358584–193880123) 30838.27 (26727.14–35688.91) 362229796 (308949982–425098891) 29042.81 (25212.74–33603.47) −0.2 (−0.22–0.19)
 African Region 128730956 (109801308–150025438) 30135.59 (26124.61–34637.86) 293881006 (250731936–344987376) 28669.68 (24920.45–33124.78) −0.18 (−0.19–0.16)
 America 197589762 (168834757–233618101) 27779.64 (23839.07–32646.74) 303443907 (264694605–348233396) 27878.84 (24286.85–32259.84) 0.07 (0.05–0.08)
 Andean Latin America 15119429 (12855413–17574944) 43349.54 (37668.29–49452.77) 28568864 (24766242–32587080) 42661.55 (37126.88–48436.02) −0.13 (−0.16–0.1)
 Asia 803597282 (675398143–964893376) 26031.66 (22095.47–30843.75) 1267510559 (1095430104–1489872130) 26093.39 (22560.27–30756.11) 0.09 (0–0.19)
 Australasia 6477118 (5717186–7408125) 29940.94 (26492.07–34316.49) 8820199 (7359582–10407446) 25919.86 (21527.97–31390.2) −0.16 (−0.38–0.06)
 Basic Health System 591513973 (491611309–711549438) 25834.81 (21714.66–30740.94) 856411433 (736410947–1005012163) 25818.45 (22195.54–30512.93) −0.02 (−0.05–0.02)
 Caribbean 12792002 (11071594–14738717) 37368.53 (32435.18–42702.97) 17228511 (15485915–19169056) 34955.75 (31393.59–39072.76) −0.16 (−0.19–0.13)
 Central Africa 17556528 (14466778–21111561) 32385.96 (27194.18–38198.78) 47303640 (38442176–57193750) 32921 (27152.85–38931.03) 0.02 (−0.02–0.06)
 Central Asia 23824101 (20056646–27778380) 36806.86 (31322.32–42521.73) 34920647 (29814943–40866997) 36158.48 (30985.72–42091.57) −0.09 (−0.12–0.05)
 Central Europe 50944530 (44755445–57424167) 39100.51 (34287.27–44110.93) 44314432 (38624122–49622538) 35601.05 (31052.06–40315.69) −0.25 (−0.29–0.21)
 Central Latin America 44896537 (37651773–53315893) 30308.39 (25882.66–35428.98) 76711304 (65441629–90046727) 29071.05 (24810.54–34084.22) 0.08 (0–0.17)
 Central Sub-Saharan Africa 14150377 (11707079–17138145) 31647.57 (26593.44–37448.66) 37667625 (30735781–45913529) 32084.16 (26431.21–38158.94) 0.01 (−0.04–0.05)
 Commonwealth High Income 34730355 (30772648–39599763) 28781.6 (25375.24–33110.8) 42287598 (37404050–47821657) 25900.16 (22693.41–29919.01) −0.27 (−0.36–0.19)
 Commonwealth Low Income 56027959 (46381406–67434405) 32670 (27820.52–38259.82) 112099598 (94369940–133829476) 30917.09 (26148.19–36488.18) −0.22 (−0.25–0.2)
 Commonwealth Middle Income 325466984 (279017759–382929490) 31516.35 (27551.07–36451.61) 614787840 (535419460–716985402) 29537.13 (25873.12–34175.15) 0.02 (−0.16–0.21)
 East Asia 252554877 (198509122–315053570) 19592.17 (15554.4–24115.63) 303804945 (257882732–364722705) 19407.08 (16361.51–23723.11) −0.05 (−0.08–0.01)
 East Asia & Pacific—WB 424621162 (346937614–515954480) 22047.51 (18338.18–26623.23) 552809117 (471216557–654986662) 21994.08 (18719.16–26396.13) −0.03 (−0.07–0.01)
 Eastern Africa 47977490 (41649016–55012773) 33325.21 (29356.96–37630.33) 109691600 (95124747–126892560) 31767.23 (27939.66–36132.44) −0.23 (−0.26–0.2)
 Eastern Europe 74128899 (63053026–86128432) 31120.81 (26487.25–36349.45) 69442629 (59343333–79717456) 30409.55 (26109.31–35460.72) −0.09 (−0.12–0.06)
 Eastern Mediterranean Region 104803782 (88906685–123587380) 31977.4 (27579.08–37214.18) 226523986 (192862706–268615266) 31056.84 (26860.97–36230.62) −0.11 (−0.12–0.09)
 Eastern Sub-Saharan Africa 53047531 (46226799–60417960) 34007.05 (30162.54–38151.75) 119153742 (102701543–137891892) 31658.72 (27830.96–36022.36) −0.25 (−0.27–0.23)
 Europe 296266968 (261012522–336488401) 34785.08 (30518.52–39693.76) 306094853 (272316471–341647095) 32455.27 (28679.51–37043.14) −0.22 (−0.23–0.21)
 Europe & Central Asia—WB 312440452 (275418551–355615853) 34884.66 (30577.04–39858.36) 332133940 (294949658–371114419) 32800.49 (28920.18–37508.71) −0.19 (−0.2–0.19)
 European Region 315502664 (278162026–359080458) 34944.58 (30618.87–39928.57) 337077234 (299492610–376696923) 32870.14 (28987.7–37574.65) −0.19 (−0.2–0.18)
 High-income Asia Pacific 30828511 (26231030–36628219) 16799.84 (14260.9–19941.81) 25622355 (22442103–29246795) 14590.94 (12662.87–17035.46) −0.41 (−0.48–0.34)
 High-income North America 60110740 (50211957–72376313) 20321.2 (16925.02–24447.62) 76334637 (65609274–87749990) 19279.64 (16329.48–22885.58) −0.06 (−0.15–0.03)
 Latin America & Caribbean—WB 138822203 (118561077–162384573) 33924 (29435.42–39162.93) 228388465 (199799420–261604229) 32945.69 (28802.12–37747.23) −0.04 (−0.06–0.01)
 Limited Health System 429009714 (364531626–505382486) 31642.43 (27619.65–36589.36) 836042203 (727030966–975954838) 30003.74 (26205.04–34676.92) −0.01 (−0.15–0.14)
 Middle East & North Africa—WB 78251396 (66525104–91773941) 34328.16 (29869.69–39523.13) 157740959 (135426950–184557845) 32869.22 (28639.06–38019.24) −0.15 (−0.17–0.13)
 Minimal Health System 39426410 (33188372–46210232) 35779.63 (30712.82–41267.3) 98059186 (81460543–116203876) 34741.78 (29637.32–40507.06) −0.1 (−0.11–0.08)
 North Africa and Middle East 107433971 (91433928–125961996) 35477.31 (30514.88–40783.05) 211987205 (182573238–248322004) 33924.85 (29422.72–39163) −0.18 (−0.22–0.14)
 North America 60120719 (50221598–72386632) 20324.7 (16928.09–24451.62) 76345757 (65619994–87762209) 19282.21 (16331.55–22888.47) −0.06 (−0.15–0.03)
 Northern Africa 36263392 (30625722–43081197) 33034.03 (28293.3–38667.95) 62679948 (53510600–74110736) 30247.58 (26035.17–35379.12) −0.27 (−0.32–0.23)
 Oceania 2393696 (2024953–2819214) 40302.13 (34541.53–46891.24) 5210674 (4426925–6204793) 39790.6 (33924.14–46817.45) −0.03 (−0.05–0.01)
 Region of the Americas 197589762 (168834757–233618101) 27779.64 (23839.07–32646.74) 303443907 (264694605–348233396) 27878.84 (24286.85–32259.84) 0.07 (0.05–0.08)
 South-East Asia Region 379281702 (322039232–447906409) 32505.23 (28291.43–37651.5) 656690887 (568776195–765137758) 30699.64 (26711.91–35550.97) 0.01 (−0.18–0.19)
 South Asia 310442858 (264458609–366002107) 32579.46 (28395.36–37753.52) 574075748 (497715820–671059371) 30710.95 (26737.41–35651.64) 0.05 (−0.15–0.24)
 South Asia—WB 319556990 (272150428–376842892) 32647.91 (28474.79–37825.55) 591882420 (513492638–692002568) 30834.61 (26878.83–35796.73) 0.04 (−0.15–0.24)
 Southeast Asia 138113503 (115912644–163825104) 31837.48 (27196.44–37118.2) 216616958 (184944503–253360017) 29770.01 (25477.06–34652.21) −0.31 (−0.42–0.21)
 Southern Africa 25512200 (21723525–29832160) 31460.83 (27120.43–36223.13) 49170273 (41405969–58058377) 29023.55 (24873.41–33857.23) −0.12 (−0.17–0.08)
 Southern Latin America 20229204 (17600581–23335394) 41401.82 (36063.88–47631.91) 30610301 (27568459–33619972) 41968.62 (37634.39–46385.41) 0.04 (−0.04–0.12)
 Southern Sub-Saharan Africa 12381387 (10323122–14858195) 26565.18 (22329.16–31459.36) 20271625 (17089338–24542143) 25097.02 (21334.22–29965.67) −0.06 (−0.1–0.03)
 Sub-Saharan Africa—WB 129837959 (110580836–151245727) 30310.97 (26280.48–34919.79) 300406127 (256140792–352088234) 28850.76 (25047.38–33308.83) −0.17 (−0.19–0.16)
 Tropical Latin America 46241724 (39027956–54788001) 31755.44 (27076.58–37097.08) 75877389 (65469946–87924720) 31305.59 (26932.19–36281.54) −0.08 (−0.12–0.03)
 Western Africa 38359079 (32664068–45282958) 26039.79 (22348.99–30460.25) 93384336 (80351676–109427859) 24544.54 (21282.78–28363.23) −0.22 (−0.23–0.2)
 Western Europe 147020642 (131014898–165909044) 34683.64 (30754.37–39461.56) 157664938 (141786027–175170206) 31592.48 (28227.43–35779.98) −0.29 (−0.35–0.24)
 Western Pacific Region 334336277 (270028233–408105311) 20730.65 (16940.46–25177.56) 418399970 (357762610–497292046) 20704.97 (17583.17–24999.72) −0.03 (−0.06–0)
 Western Sub-Saharan Africa 43248016 (36587101–51152340) 26638.41 (22793.55–31148.44) 107970027 (92376764–127107051) 25347.7 (21995.91–29425.88) −0.19 (−0.2–0.18)
 World Bank High Income 304829637 (267874801–349934208) 27805.61 (24431.37–32194.15) 346069178 (308734862–388902139) 25607.78 (22710.94–29368.79) −0.24 (−0.29–0.2)
 World Bank Low Income 86221913 (73968234–99678691) 33209.26 (28930.63–38044.79) 197621702 (169063074–230050949) 32322.46 (28052.73–37091.16) −0.08 (−0.08–0.07)
 World Bank Lower Middle Income 561262913 (477700893–664189104) 31757.46 (27583.85–36770.72) 1020909829 (883714754–1191980280) 30029.47 (26136.6–34682.23) −0.08 (−0.2–0.05)
 World Bank Upper Middle Income 512235189 (423297000–615561123) 25314.6 (21187.14–30227.6) 676057402 (579586103–792838237) 25005.34 (21357.4–29692.81) −0.03 (−0.05–0)
Country
 Afghanistan 3386219.98 (2828103.663960871.9) 39326.45 (33897.1145311.93) 10369914.3 (8691178.5912275814.95) 39316.36 (34146.3345080.81) −0.040 (−0.0910.011)
 American Samoa 16582.2 (13626.6519852.58) 37352.29 (30942.3144087.63) 19310.33 (16168.3822745.04) 37996.76 (31911.4844492.06) 0.388 (0.3520.424)
 Angola 2606839.98 (2139972.573203684.83) 31067.53 (26163.9837056.27) 7986372.11 (6320808.849815398.79) 29948.14 (24026.7736139.01) −0.262 (−0.302-0.222)
 Antigua and Barbuda 21639.97 (18435.8525197.7) 36270.33 (31008.8741946.69) 34191.24 (29372.7939690.75) 34820.8 (29758.9240454.01) 0.242 (0.2280.256)
 Arab Republic of Egypt 16244706.95 (13258350.6519822667.44) 32423.84 (26833.7238929.01) 31015607.63 (25405005.5438035079) 30753.4 (25620.0737026.87) −0.148 (−0.215-0.082)
 Argentine Republic 13425984.93 (11511339.1515510125.9) 41132.79 (35400.9247499.49) 20237458.9 (17514650.6122998002.2) 41729.71 (35948.8147651.76) 0.347 (0.3230.370)
 Australia 5633045.16 (4989428.536411667.66) 31277.64 (27782.3835580.12) 7494548.21 (6229075.938873101.35) 26407.12 (21843.2531996.39) −0.176 (−0.4700.119)
 Bangladesh 28869577.31 (23476343.9535826780.71) 32243.75 (26477.4938855.32) 51687448.67 (43013506.7862365339.82) 30972.14 (25880.4537235.72) 0.540 (0.5260.555)
 Barbados 94919.17 (81268.43110656.14) 36127.01 (3072041984.73) 117672.46 (102060.51133165.13) 35806.79 (30961.7841017.79) 0.118 (0.0940.143)
 Belize 61339.95 (52313.3871470.48) 38156.72 (32757.6543758.77) 137308.77 (115474.49160860.19) 31241.15 (26383.8236460.94) 0.088 (−0.0100.185)
 Benin 1249373.82 (1011341.531520852.89) 33077.83 (27521.9139186.34) 3652170.25 (2929564.094437289.72) 32222.68 (26462.1538277.1) 0.098 (0.0700.125)
 Bermuda 22579.65 (19000.3426194.97) 34810.15 (29263.0639968.69) 23183.1 (19768.9826840.1) 33294.85 (28382.3538740.69) −0.159 (−0.176-0.142)
 Bhutan 170784.36 (138363.97208825.3) 31583.23 (26183.2237791.89) 231823.14 (185366.92282321.05) 29379 (23718.7935192.63) 0.417 (0.4000.435)
 Bolivarian Republic of Venezuela 6600932.11 (5609343.137676402.06) 38963.42 (33898.444307.27) 10875687.11 (9340578.9912302470.13) 38881.19 (33495.2744206.22) 0.430 (0.4020.458)
 Bosnia and Herzegovina 2122982.01 (1825747.582409406.92) 45111.46 (38838.6751117.75) 1383461.84 (1188623.31565645.82) 38620.96 (33298.5644245.48) −0.402 (−0.421-0.383)
 Botswana 308062.55 (246411.55380581.47) 27564.49 (22289.4333180.63) 636390.74 (509374.58769839.91) 25922.29 (20946.2230879.1) 0.433 (0.4020.464)
 Brunei Darussalam 43615.72 (3591253355.76) 16275.32 (13568.9419506.86) 82289.21 (66191.8101518.84) 16520.26 (13486.0220024.69) 0.284 (0.2610.306)
 Burkina Faso 2428345.64 (1982137.852927932.64) 32346.16 (27085.2538267.61) 5909581.7 (4776132.57206475.57) 31315.96 (25958.8437183.51) −0.207 (−0.300-0.113)
 Burundi 1677639.43 (1372657.32012099.57) 37118.56 (31448.8443367.69) 4249004.46 (3468863.715107441.07) 37711.16 (31437.9543909.96) 0.165 (0.1350.195)
 Cabo Verde 96729.66 (80131.3115859.5) 32732.69 (27377.2938856.8) 178620.51 (146568.41216920.41) 30460.93 (25308.3136553) 0.546 (0.5190.573)
 Cameroon 2702336.76 (2158983.083323552.82) 31764.22 (25652.2238037.42) 8855152.05 (6961375.7310682360.73) 31890.91 (25853.737607.86) 0.115 (0.0690.161)
 Canada 5778177.02 (4573791.947193766.43) 19588.81 (15631.524218.45) 7667165.06 (6343672.529161869.36) 18819.02 (15577.3722936.73) −0.109 (−0.134-0.084)
 Central African Republic 740440.46 (608398.71889675.14) 32841.12 (27291.8338703.28) 1583917.03 (1308950.321916890.98) 33191.02 (28191.8439250.16) 0.196 (0.1790.213)
 Chad 1600648.8 (1320318.361929853.7) 33607.91 (28270.4239591.21) 4452794 (3608227.775417322.42) 32487.2 (26942.7938229.96) −0.262 (−0.295-0.229)
 Commonwealth of Dominica 25637.18 (21894.229564.03) 37436.81 (32053.1242864.6) 26095.19 (22122.7729788.29) 35974.1 (30605.8441169.57) 0.339 (0.3160.361)
 Commonwealth of the Bahamas 99076.02 (84751.57115229.52) 38843.13 (33646.9744393.91) 160517.26 (137858.74182388.34) 37926.24 (32575.0543103.15) 0.048 (−0.0260.121)
 Comoros 127657.28 (111592.17146748.54) 32720.27 (28810.6337144.47) 215978.76 (183385.18257797.97) 29147.38 (24818.5734529.1) 0.340 (0.2760.404)
 Congo 620029.78 (491807.5755296.99) 30562.51 (24638.1236466.51) 1533744.91 (1220297.441876748.78) 30180.41 (24424.635981.78) 0.182 (0.1360.228)
 Cook Islands 6911.45 (5797.68270.95) 37944.64 (32325.5744902.99) 6890.52 (5860.558056.51) 36688.94 (30796.2543222.71) 0.210 (0.1930.228)
 Czech Republic 4265253.28 (3606712.54884745.34) 39271.61 (33343.9145452.2) 4222924.38 (3580117.364797782.4) 37490.68 (32084.3543251.99) −0.205 (−0.272-0.138)
 Democratic People's Republic of Korea 2658293.82 (2044915.633514183.94) 12621.53 (9862.2216488.28) 3937900.91 (3081990.825001842.43) 13769.05 (10691.1117708.05) 0.112 (0.0410.184)
 Democratic Republic of the Congo 9833120.55 (8124122.3911876020.29) 31886.19 (26683.6837673.38) 25691316.75 (21117321.1631254458.91) 33031.73 (27228.5439036.15) 0.739 (0.6300.848)
 Democratic Republic of Timor-Leste 266267.67 (223390.81311294.91) 39739.37 (34255.0745634.94) 480957.64 (404566.72562681.18) 37281.08 (31757.5243133.59) 0.262 (0.2190.305)
 Democratic Socialist Republic of Sri Lanka 5666932.43 (4734122.086802278.64) 33772.28 (28401.9739601.5) 7262153.29 (6114808.448549570.06) 30817.4 (25771.136557.61) 0.228 (0.1170.340)
 Djibouti 119495.95 (104179.72138822.52) 32233.08 (28307.8136637.3) 354770.08 (295154427223.67) 28031.58 (23745.8133367.5) −0.101 (−0.135-0.067)
 Dominican Republic 2484411.19 (2104272.632904026.56) 37640.98 (32253.6143262.96) 3997043.61 (3482238.854640176.93) 35365.64 (30765.540789.81) 0.076 (0.0160.136)
 Eastern Republic of Uruguay 1336171.82 (1174978.071518991.91) 41424.02 (36296.247280.14) 1511757.38 (1342747.371717169.38) 40711.53 (35714.3546536.93) 0.183 (0.1590.207)
 Equatorial Guinea 108705.44 (89637.18130039.3) 31991.3 (26648.5137575.06) 385777.23 (309550.96475912.87) 27748.07 (22708.733321.47) 0.150 (0.1340.165)
 Eritrea 1154313.06 (983954.111367810.87) 41047.54 (36136.4947189.12) 2517723.89 (2126340.342979959.78) 41494.85 (35788.3247683.06) −0.235 (−0.392-0.077)
 Eswatini 182940.9 (144323.94226074.52) 27957.42 (22764.533627.2) 297198.33 (240127.48364392.2) 26918.35 (22136.1332510.06) 0.417 (0.3770.458)
 Ethiopia 12359263.62 (10926036.2514068323.73) 30348.39 (27129.6834199.96) 27344701.77 (23981618.5931489877) 28174.73 (24905.5132125.63) 0.441 (0.4290.453)
 Federal Republic of Germany 29917235.65 (25829889.0534854379.9) 32912.81 (28352.1438381.56) 26111218.34 (21767391.4530519240.02) 28270.29 (24108.0933301.22) 0.072 (0.0610.082)
 Federated States of Micronesia 37503.77 (31757.0244461.01) 40843.43 (35474.4647322.13) 41454.56 (35688.848968.98) 40132.67 (34835.4347078.21) −0.607 (−0.664-0.551)
 Federative Republic of Brazil 44800723.82 (37727485.5553171396) 31552.07 (26864.1136926.15) 72853873.4 (62665716.0984492498.21) 30940.85 (26571.0535900.69) 0.384 (0.3680.399)
 French Republic 26608082.47 (24188833.3429442917.26) 42606.59 (38868.2547126.04) 29886842.27 (26444980.0133384097.96) 39059.83 (33723.7344577.86) 0.264 (0.2130.315)
 Gabon 241240.68 (195003.84297142.37) 28290.41 (22903.6434197.33) 486497.19 (397404.34593530.86) 28314.39 (23653.8234066.75) −0.035 (−0.062-0.008)
 Gambia 259482.87 (205006.92318147.34) 32262.88 (26128.9438503.96) 683960.8 (554142.02823950.37) 32348.48 (2632238249.44) 0.241 (0.2150.266)
 Georgia 2072322.4 (1759563.992410893.03) 36208.54 (30605.5742347.13) 1384534.9 (1173468.411587062.15) 36155.7 (30402.8442138.42) 0.145 (0.1090.182)
 Ghana 3554177.71 (2859985.044398435.82) 28131.49 (22959.4734123.49) 8572845.4 (6872457.1510464275.39) 26905.24 (22058.3432426.84) −0.017 (−0.1140.081)
 Grand Duchy of Luxembourg 151323.08 (129366.86173139.48) 35046.08 (29681.0340638.96) 248675.99 (211532.75285096.38) 33273.07 (28133.6738678.75) 0.076 (0.0250.128)
 Greenland 11221.69 (8995.1314098.38) 18830.39 (15379.5323112.02) 10865.3 (8752.8213043.73) 18125.08 (14618.7221972.12) −0.071 (−0.115-0.027)
 Grenada 29645.45 (25447.3334197.77) 37840.66 (32487.8243273.47) 39557.03 (34289.245403.61) 35811.33 (31015.1441182.79) −0.060 (−0.095-0.025)
 Guam 48814.69 (40433.0458651.97) 35868.69 (30142.5942457.53) 58732.49 (48202.1868721.71) 35551 (29011.8441788.11) 0.392 (0.3430.442)
 Guinea 1600176.89 (1308615.031929249.75) 32707.3 (27236.4338905.54) 3676878.38 (3018413.134486229.02) 32540.05 (27182.2338776.58) 0.116 (0.0980.134)
 Guinea-Bissau 335993.57 (286462.89402003.38) 40579.82 (35137.1946900.98) 697536.14 (589029.74826106.62) 39349.69 (34156.9345730.24) 0.021 (−0.0050.047)
 Hashemite Kingdom of Jordan 1223300.36 (1013417.291462510.6) 37599.61 (32122.343925.27) 4515034.11 (3793226.725359143.81) 36380.86 (30706.3242528.71) 0.089 (0.0610.118)
 Hellenic Republic 4881208.26 (4425735.015400391.69) 43280.26 (39179.0247841.58) 4547904.1 (3962818.455121709.83) 37619.27 (32253.643327.99) 0.274 (0.2260.322)
 Hungary 4112494.49 (3506667.524740633.85) 37470.63 (31591.3343299.53) 3569974.34 (3000598.974125068.75) 34910.22 (29659.6841093.14) −0.133 (−0.202-0.064)
 Independent State of Papua New Guinea 1501700.44 (1268059.891778725.52) 40655.59 (34964.8147464.21) 3887172.78 (3288325.524658225.66) 39925.45 (34099.6947082.73) −0.232 (−0.265-0.198)
 Independent State of Samoa 61122.28 (51214.0972153.48) 40214.6 (34295.8247007.49) 78833.96 (67933.9492462.55) 39651.5 (34213.3146073.58) 0.101 (0.0760.126)
 India 252092740.7 (216680467.29295774383.1) 33443.05 (29295.3638509.09) 457442136.97 (400192193.1529122514.21) 31414.86 (27600.636238.98) 0.045 (0.0340.056)
 Ireland 1379325.7 (1181568.41607522.31) 37517.01 (32040.643638) 1885154.4 (1598315.072182485.02) 34152.95 (28680.8939859.54) 0.585 (0.3430.828)
 Islamic Republic of Iran 15701574.1 (13550378.0618146124.31) 32059.87 (28112.7336505.73) 28067972.48 (24281032.4532187568.32) 31184.5 (27490.5935341.85) −0.076 (−0.113-0.039)
 Ivoire 3179483.42 (2547948.753934150.73) 31777.57 (26196.2838107.38) 7619289.16 (6093190.389269910.06) 31096.54 (25622.0636752.21) 0.512 (0.2830.741)
 Jamaica 834151.95 (715711.9966781.41) 37432.11 (32253.3842952.36) 1101422.43 (946276.531262459.31) 36344.06 (31249.3341647.75) 0.378 (0.3660.391)
 Japan 19599797.2 (16638127.0523335189.4) 15088.81 (12752.7217872.64) 13027573.81 (11394520.9614802488.82) 11763.65 (10209.3713635.36) −1.358 (−1.539-1.177)
 Kenya 5105739.84 (4348573.026013889.79) 27073.76 (23436.7631121.97) 11992831.14 (10321755.3814051272.16) 25546.42 (22322.3129262.63) 0.279 (0.2500.309)
 Kingdom of Bahrain 174399.16 (142337.86211420.68) 35267.62 (29888.7941345.49) 574424.89 (475774.43682234.03) 34221.43 (28787.640281.77) 0.312 (0.2780.346)
 Kingdom of Belgium 3094500.18 (2561872.923690728.54) 27827.3 (22824.8733715.14) 3467386.95 (2867974.124080781.53) 26678.42 (21774.532456.76) −0.124 (−0.177-0.072)
 Kingdom of Cambodia 3399725.64 (2853951.513998209.24) 39329.24 (34010.4445078.76) 6207864.42 (5217005.097277496.26) 36943.78 (31237.0242446.64) 0.441 (0.3500.533)
 Kingdom of Denmark 1153778.37 (911075.321416328.33) 19901.65 (15721.6124475.84) 1353441.22 (1088632.261607299.75) 21993.88 (18074.5726277.64) −0.137 (−0.215-0.059)
 Kingdom of Norway 1421480.4 (1237020.341614607.27) 30245.91 (25901.2434857.38) 1806219.64 (1568779.782029873.73) 29152.31 (25053.4533707.75) 0.503 (0.3080.698)
 Kingdom of Spain 16788311.77 (14705348.9819136534.13) 39770.37 (34583.8645360) 19355675.9 (16751823.621727790.65) 35675.2 (30731.1140904.96) −0.151 (−0.290-0.012)
 Kingdom of Sweden 2638885.33 (2173829.743202245.27) 28388.74 (23445.3634786.94) 3600711.54 (3039589.984197322.77) 30714.64 (25671.9736407.77) 0.444 (0.3060.583)
 Kingdom of Thailand 18721483.33 (15446916.5622591493.04) 32805.67 (27452.0838680.68) 23081133.41 (19118337.427176226.86) 30733.79 (25497.4236682.94) 0.125 (0.1040.146)
 Kingdom of the Netherlands 4898221.59 (4324715.365558472.81) 30052.52 (26415.2134108.94) 4097254.31 (3380827.784863030.38) 22548.32 (18625.3627171.23) −0.615 (−0.815-0.414)
 Kingdom of Tonga 35563.1 (29777.2542463.8) 40227.16 (34395.4647264.3) 38968.97 (33441.8245765.54) 39288.14 (33967.7645821.09) 0.054 (0.0330.074)
 Kyrgyz Republic 1529423.15 (1278071.161792490.67) 37365.89 (31315.4143460.62) 2505551.45 (2129167.732926578.08) 37618.83 (32095.343647.27) 0.185 (0.0840.285)
 Lao People's Democratic Republic 1191035.14 (982085.221426238.96) 33067.75 (27924.6938726.92) 2170654.46 (1741308.082656741.24) 29964.77 (24368.6335767.79) 0.201 (0.1480.255)
 Lebanon 1045648.47 (873475.411231209.38) 37000.87 (31192.2543241.47) 2094604.69 (1760566.442453669.47) 35897.3 (30221.3642020.18) 0.209 (0.1940.224)
 Lesotho 387093.73 (314229.4473055.43) 29988.14 (24734.6235912.37) 521021.96 (421831.02644102.11) 28559.32 (23148.4334803.06) 0.264 (0.2310.298)
 Liberia 667254.07 (543554.56800315.29) 32992.99 (27229.5638790.62) 1642185.45 (1323924.041965636.68) 33362.96 (27871.439323.51) 0.189 (0.1350.243)
 Libya 1296912.94 (1051740.971544295.7) 34688.35 (28872.2640812.29) 2719929.74 (2252723.923194260.34) 36795.29 (30873.6542936.79) 0.717 (0.6760.758)
 Madagascar 5274085.68 (4572043.25975613.01) 50434.79 (44563.8756444.1) 11549218.24 (9927442.4913357905.2) 45951.54 (40298.8651554.54) −0.317 (−0.466-0.167)
 Malawi 3014988.17 (2540016.793583479.04) 37531.84 (32441.3943449.14) 6319517.79 (5257633.927596949.07) 36863.08 (31776.2642937.33) 0.086 (0.0340.138)
 Malaysia 4453688.52 (3547057.525518681.19) 26752.28 (21579.7932497) 8208726.05 (6641796.4810200156.73) 24435.27 (19914.8930195.87) 0.092 (0.0390.146)
 Mali 2340288.21 (1913099.542803160.97) 33686.95 (28094.1239858.59) 6292583.43 (5169055.267697430.29) 32446.19 (27005.8138621.83) −0.191 (−0.219-0.163)
 Mauritania 552159.11 (449298.21665502.23) 32228.43 (26587.4438098.04) 1211049.23 (977134.961471226.03) 31511.95 (26075.0837607.9) −0.043 (−0.0860.001)
 Mauritius 354553.92 (293423.44424268.72) 32283.48 (27074.4438159.91) 426765.75 (357248.65499286.79) 30193.28 (25004.9635938.66) 0.158 (0.1450.172)
 Monaco 12088.62 (10169.3713953.44) 33001.79 (27722.6938829.35) 14173.42 (12001.8816531.02) 31265.84 (26374.3336894.72) −0.216 (−0.256-0.176)
 Mongolia 719157.15 (605901.71845841.06) 37681.2 (32223.4643600.85) 1175207.04 (978614.391383130.85) 35985.02 (30267.2441991.11) 0.181 (0.0410.322)
 Montenegro 282605.99 (242772.63323657.18) 43866.17 (37693.8550224.49) 263821.8 (227936.58299737.21) 39720.3 (34254.0245563.97) −0.154 (−0.185-0.122)
 Morocco 7044689.68 (6219161.368179211.27) 29533.83 (26325.2633708.6) 7410678.33 (6133000.968889966.92) 19482.87 (16184.7323308.4) −1.000 (−1.323-0.676)
 Mozambique 5236610.96 (4519240.535918225.64) 47024.33 (41605.0552026.77) 9738967.41 (8006972.811682555.78) 37448.06 (31895.7943763.47) −0.486 (−0.613-0.359)
 Namibia 367006.34 (297673.54440688.99) 30729.75 (2517636567.38) 713596.25 (581050.99871085.85) 30384.81 (25259.8336494.37) 0.453 (0.3360.572)
 Nauru 3433.15 (2841.664153.93) 37422.93 (31508.6844322.94) 4000.13 (3307.774768.23) 38090.6 (31823.9344824.63) 0.198 (0.1070.290)
 Nepal 5075932.07 (4160816.996281345.15) 31057.05 (25628.5937814.74) 8823516.05 (7246888.9610770591.1) 28571.68 (23537.9834568.29) 0.222 (0.1200.325)
 New Zealand 844073.12 (703737.571018285.18) 23299.18 (19367.6728127.32) 1325651.1 (1095055.21565699.5) 23480.5 (19329.9928253.23) 0.161 (−0.0080.330)
 Niger 2219761.05 (1848980.072633504.34) 35761.42 (30399.7541843.52) 6833830.54 (5629709.88196053.9) 35394.97 (30111.1341035.08) −0.431 (−0.566-0.295)
 Nigeria 16306467.56 (13983934.5519230278.64) 20804.31 (17737.7224287.73) 39644079.14 (34308645.6946397455.61) 19271.23 (16702.0922428.2) −0.276 (−0.327-0.224)
 Niue 858.73 (723.941009.7) 39026.96 (32885.7346068.99) 668.28 (574.25777.66) 38182 (32959.3644670.57) 0.154 (0.1120.195)
 North Macedonia 898771.12 (764223.941024289.55) 43821.89 (37270.4549930.99) 951327.11 (824885.931085149.34) 39380.79 (33867.7445331.8) −0.008 (−0.0460.031)
 Northern Mariana Islands 16763.61 (13491.1520487.76) 36092.86 (30281.2242835.63) 18743.41 (15724.7522125.34) 36578.43 (30648.9143271.08) 0.213 (0.1530.274)
 Oman 663877.81 (550363.88792818.07) 37896.12 (32119.6943989.12) 1792700.42 (1486415.22136989.48) 36782.64 (31296.4742694.81) 0.268 (0.2060.331)
 Pakistan 24233823.43 (19941558.1329635624.6) 25696.95 (21403.8130907.16) 55890823.61 (46619094.8568403069.49) 25988.02 (21892.4231138.37) 0.271 (0.1900.352)
 Palau 5867.69 (4904.616975.3) 38321.55 (32357.7844925.45) 7499.6 (6180.298730.18) 37883.17 (31071.4344402.47) 0.208 (0.1750.242)
 Palestine 570077.42 (463629.81687563.48) 33433.25 (27734.7439433.87) 1555550.1 (1275001.661904829.04) 31976.16 (26772.9238317.68) 0.401 (0.3250.477)
 People's Democratic Republic of Algeria 8215595.44 (6834202.639929343.15) 36507.03 (30861.9142649.59) 15808777.49 (13427728.4718851833.02) 36017.33 (30782.2142684.35) 0.225 (0.1300.321)
 People's Republic of China 247030844.32 (194257990.56307748803.28) 19827.23 (15730.4624395.1) 296616329.59 (252252744.17355044543.51) 19634.62 (16565.823954.9) 0.027 (−0.0650.119)
 Plurinational State of Bolivia 2504919.59 (2120721.312918113.12) 44129.34 (38151.4650048.47) 5062261.32 (4386041.55833768.44) 43096.73 (37458.5949194.56) 0.309 (0.2930.325)
 Portuguese Republic 3454607.34 (2882853.354077239.6) 31047.2 (25616.6636990) 3714960.76 (3110872.934358168.31) 29546.82 (24739.0135045.19) −0.031 (−0.0750.013)
 Principality of Andorra 21245.05 (17943.9924805.35) 34706.32 (29352.140572.67) 34958.88 (29218.1540132.41) 33502.38 (28146.7138966.23) 0.068 (0.0300.106)
 Puerto Rico 1292773.59 (1114093.951491689.46) 35273.44 (30382.8440658.23) 1236171.13 (1069138.021405951.61) 34287.29 (29391.5539735.52) 0.145 (0.1360.153)
 Qatar 150434.86 (120650.09184154.57) 33329.11 (28139.0139682.58) 1106161.97 (890241.61370201.74) 32817.68 (27459.1539201.29) 0.314 (0.2730.356)
 Republic of Albania 1342776.71 (1147150.531541453.76) 41713.1 (35806.1347540.28) 1118736.04 (955628.181279072.14) 38834.79 (33232.1544724.81) 0.106 (0.0720.139)
 Republic of Armenia 1258102.41 (1075524.951466823.27) 37213.59 (31942.443136.61) 1170526.45 (994774.51347257.05) 36157.29 (30853.8342060.87) 0.143 (0.0540.231)
 Republic of Austria 2676225.86 (2292757.243112105.01) 30801.75 (26115.1636087.44) 3068331.72 (2610325.233554185.72) 29456.78 (25210.6934889.41) −0.001 (−0.0460.044)
 Republic of Azerbaijan 2555421.17 (2114690.643020212.63) 36213.94 (30261.8542267.74) 4020457.54 (3396880.24679183.97) 35523.67 (30041.2341354.73) 0.243 (0.1420.344)
 Republic of Belarus 3479793.22 (2882645.984087455.24) 31850.52 (26556.2637699.74) 3169279.31 (2642714.623684309.52) 31334.27 (26238.2737015.17) −0.001 (−0.0800.078)
 Republic of Bulgaria 3937914.73 (3423204.154444849.73) 42760.19 (36818.448662.19) 2939438.9 (2518029.973312554.29) 39865.19 (34538.2745444.11) −0.185 (−0.243-0.127)
 Republic of Chile 5466086.21 (4834287.646331354.61) 42079.77 (37284.4848140.57) 8859394.89 (8604440.079139428.09) 42647.53 (40975.4544539.69) 0.279 (−0.0370.596)
 Republic of Colombia 10133688.42 (8371113.4412044980.11) 33263.84 (27619.7738892.55) 16721462.38 (13743057.5920015015.38) 31798.07 (26033.0738040.02) 1.315 (0.9191.713)
 Republic of Costa Rica 1015280.45 (844070.261199747.35) 36419.88 (30898.3242087.27) 1785896.15 (1522876.922061582.79) 34874.96 (29643.6840522.82) 0.395 (0.3620.428)
 Republic of Croatia 2309665.57 (1997788.732605655.06) 44982.65 (38467.9950731.49) 1843251.45 (1573123.512082423.98) 40554.61 (34538.9846279.72) −0.184 (−0.227-0.140)
 Republic of Cuba 4230665.18 (3652562.684869300.37) 37122.36 (32193.1542330.93) 4444656.65 (3825200.715063540.37) 35857.49 (30879.9441454.52) 0.150 (0.0320.268)
 Republic of Cyprus 294270.21 (251542.77342512.83) 36333.04 (30990.3442372.92) 543887.67 (461565.89624142.85) 34653.01 (29342.8640426.28) 0.225 (0.2090.241)
 Republic of Ecuador 3958688.12 (3341755.924666969.85) 42963.18 (36750.849132.98) 7821355.85 (6728413.859023886.25) 42848.49 (36956.8149183.63) −0.065 (−0.1890.060)
 Republic of El Salvador 1755462 (1489568.542054338.15) 37630.21 (32408.3943101.9) 2326544.76 (1972681.642710321.13) 35944.49 (30252.4241605.09) 0.339 (0.3020.375)
 Republic of Estonia 359791.09 (289570.88435558.08) 22177.89 (17803.4527091.1) 277939.73 (218308.5337440.1) 20798.57 (16449.1525974.74) −0.320 (−0.386-0.253)
 Republic of Fiji 284128.77 (237390.88337031.32) 39442.93 (33451.0146353.49) 359016.15 (304455.27423853.6) 38709.25 (32978.6645414.72) 0.055 (−0.0560.166)
 Republic of Finland 1339007.45 (1106860.871602192.13) 24190.07 (20002.4529300.21) 1434408.31 (1187528.081686137.4) 22807.45 (18770.4227575.01) −0.083 (−0.2840.119)
 Republic of Guatemala 2504759.47 (2085248.742951376.12) 37228.8 (31846.2842959.76) 5537787.5 (4621022.346509759.74) 36054.19 (30191.7541771.9) 0.543 (0.5050.581)
 Republic of Guyana 277315.77 (236634.48322222.04) 38488.51 (33067.5243928.37) 281530.3 (240560.61326965.72) 36233.22 (31095.741846.63) 0.177 (0.1500.203)
 Republic of Haiti 2204450.43 (1884719.242556119.08) 39614.09 (34641.6945305.81) 4300779.18 (3645151.895020530.12) 34351.49 (29490.4539499.13) 0.068 (0.0020.133)
 Republic of Honduras 1448843.66 (1214806.031700885.06) 37672.86 (32303.7843218.5) 3585246.68 (2999901.424220465.26) 36841.78 (31258.3842573.04) 0.447 (0.4390.454)
 Republic of Iceland 108258.32 (98520.11118417.5) 41419.44 (37656.1945281.13) 128153.29 (110092.61146957.49) 34244.77 (29169.4239979.91) −0.526 (−0.577-0.476)
 Republic of Indonesia 55327423.04 (46525198.2465226282.47) 32234.37 (27516.6737429.65) 89851881.34 (76783390.74104871373.57) 30814.66 (26496.7735610.29) 0.111 (−0.0960.319)
 Republic of Iraq 5835612.61 (4852518.677004895.92) 36902.47 (31257.3142960.21) 14449254.61 (12025144.3817117142.19) 35913.33 (30303.0442010.31) 0.205 (0.1710.240)
 Republic of Italy 19636610.41 (16537615.0622991120.73) 30642.57 (25439.236615.39) 20343859.07 (17207344.7323311901.32) 28731.37 (24370.6534131.42) −0.099 (−0.124-0.075)
 Republic of Kazakhstan 5774148.35 (4818496.046762384.45) 35922.07 (30175.9141787.48) 6695959.57 (5659190.157800943.81) 34966.77 (29729.2440883.74) 0.051 (−0.0500.153)
 Republic of Kiribati 27650.45 (23714.8532771.34) 40941.21 (35207.7448092.79) 48087.79 (41031.0256637) 41191.64 (35686.3348058.75) 0.245 (0.2220.269)
 Republic of Korea 10587237.46 (8850382.1112712157.84) 22326.53 (18725.6326479.28) 11534001.16 (9789818.9713412164.89) 20631.46 (17625.3424172.05) −0.283 (−0.301-0.265)
 Republic of Latvia 885860.47 (742472.011031861.23) 31686.8 (26370.3637308.96) 610260.52 (508976707833.2) 30775.71 (25758.4436611.9) −0.103 (−0.165-0.041)
 Republic of Lithuania 1446817.32 (1265750.61640220.86) 37858.21 (33048.9542849.4) 1028637.33 (875867.681176420.04) 34671.35 (29665.3540306.46) −0.223 (−0.307-0.138)
 Republic of Maldives 60979.51 (50376.9573499.25) 33045.75 (27719.4638671.32) 174603.74 (140668.83212289.67) 30880.07 (25443.8236491.04) 0.677 (0.6210.732)
 Republic of Malta 146842.13 (124111168714.93) 37117.79 (31493.0142733.83) 179507.08 (154164.46204826.22) 34519.75 (29000.0840111.88) 0.162 (0.1300.195)
 Republic of Moldova 1507163.33 (1258719.031767791.7) 33383.82 (27879.5539132.76) 1331747.83 (1102818.351558580.76) 33134.94 (27442.1739403.69) 0.287 (0.1950.378)
 Republic of Nicaragua 1197365.84 (994784.331410453.71) 37668.93 (32039.3843213.41) 2435539.71 (2058384.942827745.53) 36755.61 (31509.7642142.95) 0.534 (0.5010.568)
 Republic of Panama 1021838.82 (889359.821167245.83) 45240.74 (39871.5950681.9) 1829550.37 (1582107.062064313.87) 41767.23 (36079.0647134.02) −0.050 (−0.091-0.008)
 Republic of Paraguay 1441000.49 (1218735.381689908.67) 39881.91 (34394.8245799.88) 3023516.09 (2587503.23458389.42) 41395.43 (35667.3947174.64) 0.630 (0.5880.672)
 Republic of Peru 8655821.3 (7380147.7810058232.75) 43307.07 (37764.349366.66) 15685246.62 (13545247.218036371.62) 42434.49 (36825.5648595.21) 0.259 (0.2290.290)
 Republic of Poland 12350296.47 (10756819.3514074981.59) 31242.84 (27240.0735568.67) 12347960.89 (10902713.5113769235.17) 29723.56 (26118.8933866.68) 0.016 (−0.0580.090)
 Republic of Serbia 4315950.68 (3645516.674940583.92) 42988.45 (36210.6649412.46) 3631507.95 (3122073.124176008.57) 37484.85 (31754.1743407.59) 0.284 (−0.1250.695)
 Republic of Singapore 597860.92 (493161.37730126.27) 17355.66 (14473.3320916.3) 978491.2 (786994.441177574.45) 16443.73 (13339.2719902.17) −0.394 (−0.470-0.317)
 Republic of Slovenia 784185.48 (679530.38888840.63) 37405.62 (32532.9242263.53) 769531.82 (646416.76877512.04) 35079.43 (29611.2840774.11) −0.198 (−0.261-0.136)
 Republic of Suriname 106658.12 (88697.54128744.52) 28246.23 (23367.8333816.49) 163350.77 (133317.46193505.46) 27155.74 (22299.9132465.41) 0.009 (−0.0290.047)
 Republic of Tajikistan 1731252.37 (1456048.722028662.53) 37589.38 (31715.1943360.78) 3650545.08 (3135420.424253678.74) 37958.06 (33082.8543699.66) 0.392 (0.2990.485)
 Republic of the Marshall Islands 15770.22 (13105.8918879.43) 40375.99 (34238.6147627.95) 22510.1 (19167.1326774.57) 40132.44 (34305.3647294.29) 0.437 (0.4090.464)
 Republic of the Philippines 18206235.49 (15482060.6621337146.19) 32748.72 (28604.5937591.96) 35639298.18 (31347767.2540659804) 31952.1 (28304.0436132.1) 0.167 (0.0090.326)
 Republic of the Union of Myanmar 10371288.19 (8458878.8112749054.99) 27008.57 (22323.8532581.45) 13717331.44 (11013599.5916709143.69) 23852.58 (19262.7628920.77) −0.265 (−0.315-0.215)
 Republic of Trinidad and Tobago 423818.51 (358810.5496925.82) 36329.19 (30822.6842212.55) 407691.45 (344694.65482001.72) 27646.31 (2337232809.12) −0.673 (−0.733-0.612)
 Republic of Uzbekistan 6990696.02 (5887813.438219994.78) 37712.31 (32033.0143358.58) 12505160.92 (10566697.7314719558.1) 36469.26 (31046.1642716.96) 0.357 (0.2440.471)
 Republic of Vanuatu 53643.57 (44849.0363102.82) 40665.4 (34723.7947405.49) 119090.06 (101426.4140463.85) 40667.94 (34925.2347443.09) 0.219 (0.2030.236)
 Romania 11220979.8 (9744485.5212604461.57) 46315.8 (40312.2252113.64) 8437494.65 (7277719.659463447.93) 41316.4 (35536.3546916.14) −0.328 (−0.362-0.293)
 Russian Federation 50881084.46 (43367381.8558944716.74) 32074.45 (27379.5737380.77) 49374922.77 (42642704.956430473.91) 30939.62 (26710.5535758.14) −0.007 (−0.0740.061)
 Rwanda 2193062.35 (1802080.82619915.61) 37380.46 (31865.5543560.95) 4362260.36 (3600658.775262021.86) 35668.16 (30003.9741639.66) 0.252 (0.2290.274)
 Saint Kitts and Nevis 14344.78 (12281.5616644.62) 36610.59 (31352.2742237.35) 22777.63 (19327.8326341.98) 34676.18 (29260.8339946.32) 0.418 (0.4010.436)
 Saint Lucia 46975.97 (40021.6654697.3) 37388.93 (31882.6843028.98) 70653.75 (61044.4980976.02) 35756.78 (30918.0941130.43) 0.529 (0.5040.554)
 Saint Vincent and the Grenadines 50639.06 (44212.6257716.5) 47461.79 (41736.1553353.17) 49916.14 (43796.3456127.14) 41019.54 (3576346162.92) −0.223 (−0.375-0.071)
 San Marino 9377.86 (8061.9910769.77) 34986.03 (29514.7240637.76) 13264.97 (1146515235.3) 34061.24 (28982.4939689.81) 0.012 (−0.0400.064)
 Sao Tome and Principe 32365.61 (26357.9139261.9) 32328.62 (26641.1238957.48) 65436.2 (53041.4978979.53) 31861.01 (26132.3537860.97) 0.272 (0.2280.315)
 Saudi Arabia 5627156.44 (4668180.576646948.52) 40301.19 (34347.7346343.29) 15928216.65 (13402966.2118668143.07) 39279.33 (33844.2844915) 0.305 (0.2280.381)
 Senegal 1765694.94 (1513638.132038012.24) 28467.32 (24722.3532571) 3560999.76 (2945415.484283126.52) 24454.05 (20518.3929020.89) 0.054 (−0.0110.118)
 Seychelles 22368.25 (18634.1726776.98) 31613 (26366.0737482.11) 33515.25 (27932.5339861.17) 29946.26 (25137.2135576.08) 0.115 (0.0650.165)
 Sierra Leone 1378533.93 (1248532.031524492) 37690.6 (34240.5441758.42) 2420148.26 (2067727.622860879.2) 30328.14 (25983.9135209.33) −0.610 (−0.817-0.403)
 Slovak Republic 2185955.36 (1865028.22506485.75) 39997.57 (34138.4446084.07) 2189989.31 (1874933.182519982.85) 37336.63 (31912.143283.13) −0.126 (−0.201-0.050)
 Socialist Republic of Viet Nam 19871728.04 (16430134.0523881755.86) 31842.5 (26534.537499.82) 29059937.68 (23188093.2334807069.18) 27864.27 (22549.2933331.27) −0.319 (−0.565-0.073)
 Solomon Islands 120453.71 (101655.99142795.4) 41258.79 (35267.7647897.76) 260301.93 (221072.89308386.64) 40936.04 (35152.1447921.3) 0.225 (0.2040.247)
 Somalia 2530038.58 (2089411.242992588.63) 39636.11 (34069.0445910.08) 6991308.43 (5834918.648309094.69) 39988.6 (34477.9646218.26) −0.022 (−0.0530.010)
 South Africa 9106780.62 (7625359.6210880663.01) 26895.79 (22761.2531662.12) 14781698.34 (12548857.7917723960.49) 25047.02 (21447.4829675.65) 0.264 (0.1950.334)
 South Sudan 1714905.16 (1402940.752072468.36) 34631.35 (28911.1340865.2) 2981511.09 (2458916.953591164.48) 36212.09 (30658.0942372.04) 0.087 (0.0280.147)
 State of Israel 2027819.88 (1765012.882306433.73) 41847.85 (36461.4147546.66) 3823324.82 (3317070.844354863.41) 38993.23 (33912.7244631.79) −0.039 (−0.069-0.009)
 State of Kuwait 578835.35 (474392.07701974.37) 34400.7 (28973.6540523.41) 1738319.11 (1387565.182105395.61) 33614.18 (27747.7639856.11) 0.272 (0.2370.308)
 Sudan 6792560.53 (5647283.377989631.41) 39420.46 (33022.0845687.22) 15342590.11 (12915097.318297899.34) 38272.86 (32833.5344500.75) 0.044 (−0.0070.096)
 Swiss Confederation 3524799.14 (3203625.123869039.17) 45805.73 (41131.3150762.03) 4627113.06 (4217345.125036982.12) 44429.86 (39765.3350005.32) 0.051 (0.0250.076)
 Syrian Arab Republic 4148101.81 (34702164910992.39) 38423.53 (33034.2244409.37) 5477835.75 (4587046.456394293.24) 37573.79 (31920.3543442.56) 0.534 (0.4660.601)
 Taiwan (Province of China) 2865738.63 (2191120.743784546.28) 13232.68 (10277.1117228.65) 3250714.7 (2541245.134113545.68) 12679.47 (9754.9116611.84) 0.028 (−0.0240.081)
 Togo 977315.48 (795619.161176453.23) 33323.99 (27761.4238954.44) 1999626.87 (1699366.182411359.54) 25785.4 (21488.7830619.14) 0.012 (−0.1360.160)
 Tokelau 597.11 (509.37704.23) 40216.86 (34789.3847147.52) 545.32 (466.67632.82) 38978.21 (33397.8945564.28) 0.201 (0.1640.238)
 Tunisia 2909327.69 (2437150.533425526.27) 37288.86 (31686.843226.16) 4513906.04 (3805192.395235647.07) 36187.06 (30406.2942228.32) 0.277 (0.2030.352)
 Turkey 21239180.95 (17899212.5424881102.13) 39039.94 (33445.9345077.74) 32693622.45 (27668936.3837835038.22) 36687.5 (31102.4742631.25) 0.074 (−0.0740.223)
 Turkmenistan 1193577.59 (1011090.961423805.6) 36150.75 (30810.242019) 1812704.39 (1519848.932134953.03) 35046.46 (29548.4541116.73) 0.262 (0.1810.344)
 Tuvalu 3625.54 (3068.664235.45) 41371.4 (35286.1748072.19) 4903.1 (4162.975760) 39881.97 (33985.9946661.73) 0.180 (0.1630.197)
 Uganda 3511768.43 (2797997.494384841.46) 25312.14 (20542.2431021.47) 8816416.88 (7082126.3211104277.51) 24008.29 (19210.4829470.77) 0.029 (−0.0290.087)
 Ukraine 15568388.82 (12779161.7518219383.4) 27867.93 (22940.7332820.36) 13649841.92 (11317446.5616053697.22) 28270.7 (23847.1533748.53) 0.149 (0.0680.229)
 United Arab Emirates 610660.97 (494843.9755853.14) 32990.76 (27770.2439142.71) 3729701.47 (2845809.64556536.41) 33294.66 (27549.2139528.38) 0.613 (0.5630.663)
 United Kingdom of Great Britain and Northern Ireland 20716303.75 (18582080.4923172860.1) 32774.38 (29232.5337067.88) 23239693.21 (20997723.6225744201.97) 30296.17 (27062.5734150.95) −0.166 (−0.248-0.085)
 United Mexican States 19218366.44 (15990112.3723341197.7) 24755.35 (20606.6129677.84) 31613589.82 (26433121.6737573527.79) 23261.87 (19496.6727577.49) 0.190 (0.1380.242)
 United Republic of Tanzania 6717677.51 (5598169.787984487.28) 32344.8 (27034.3538053.2) 16762007.85 (13514473.7420481623.83) 32322.78 (26384.8938333.56) −0.493 (−0.793-0.192)
 United States of America 54319962.3 (45472132.0365322973.35) 20396.57 (17026.6924562.88) 68655409.32 (59125324.9978946284.96) 19321.53 (16431.6522797.83) −0.025 (−0.1120.063)
 United States Virgin Islands 37807.04 (31957.1443601.86) 35625.3 (30394.4640784.56) 30960.77 (26526.9735545.69) 33765.11 (28771.539260.81) 0.065 (0.0230.106)
 Yemen 3916326.46 (3224379.14749606.98) 35770.5 (30311.2142395.82) 10884681.54 (9058476.8512906420.36) 35591.65 (30068.0641974.16) 0.375 (0.2320.518)
 Zambia 2272373.17 (2040610.932528257.21) 33565.39 (30281.5237408.93) 4853790.09 (4057080.865888997.53) 27032.79 (22700.2832374.68) −0.250 (−0.367-0.133)
 Zimbabwe 2029503.16 (1622715.912518744.48) 23262.35 (18773.127997.01) 3321719.63 (2619813.544272098.05) 23506.58 (18778.7729375.73) 0.242 (0.2130.270)

Table 3.

The number of DALYs cases and the age-standardized DALYs rate attributable to caries of permanent teeth in 1990 and 2021 and its trends from 1990 to 2021 globally

Number of DALYs cases (95% UI) in 1990 The age-standardized DALYs rate/100000 (95% UI) in 1990 Number of DALYs cases (95% UI) in 2021 The age-standardized DALYs rate/100000 (95% UI) in 2021 EAPC (95% CI)
Global 1443191 (622669–2764557) 27.78 (12.3–53) 2198064 (988183–4174725) 27.02 (12.1–51.36) −0.03 (−0.08–0.02)
Sex
 Female 724436 (313504–1383004) 27.95 (12.38–53.24) 1102864 (497296–2084214) 27.14 (12.15–51.39) −0.03 (−0.09–0.02)
 Male 718755 (309244–1381436) 27.62 (12.23–52.78) 1095201 (490402–2090511) 26.91 (12.02–51.33) −0.03 (−0.08–0.02)
Age
 5–9 years 55853 (18303–131336) 9.57 (3.14–22.51) 55891 (18251–132352) 8.13 (2.66–19.26) −0.31 (−0.41–0.21)
 10–14 years 141166 (55276–301104) 26.35 (10.32–56.21) 160234 (61633–333641) 24.04 (9.25–50.05) −0.17 (−0.24–0.09)
 15–19 years 159969 (60144–335800) 30.8 (11.58–64.65) 192017 (72853–399324) 30.77 (11.68–64) 0.06 (−0.01–0.13)
 20–24 years 193927 (73710–373123) 39.41 (14.98–75.82) 227353 (86741–444138) 38.07 (14.53–74.38) −0.09 (−0.13–0.05)
 25–29 years 166731 (67415–321046) 37.67 (15.23–72.53) 220414 (91562–418358) 37.46 (15.56–71.11) 0.04 (−0.02–0.1)
 30–34 years 134997 (56018–261664) 35.03 (14.53–67.89) 210136 (87753–410865) 34.76 (14.52–67.97) 0.08 (0.01–0.15)
 35–39 years 123454 (50523–246483) 35.05 (14.34–69.98) 200824 (81549–401372) 35.81 (14.54–71.56) 0.11 (0.06–0.15)
 40–44 years 100636 (39181–196930) 35.13 (13.68–68.74) 179011 (71794–354066) 35.78 (14.35–70.78) 0.06 (0.01–0.11)
 45–49 years 81014 (33387–166801) 34.89 (14.38–71.84) 162496 (67739–333485) 34.32 (14.31–70.43) −0.03 (−0.1–0.04)
 50–54 years 73394 (30171–154280) 34.53 (14.19–72.58) 146472 (60534–303201) 32.92 (13.61–68.15) −0.08 (−0.14–0.02)
 55–59 years 62372 (26836–133418) 33.68 (14.49–72.04) 127002 (54586–272450) 32.09 (13.79–68.85) −0.08 (−0.13–0.04)
 60–64 years 53060 (22141–107473) 33.04 (13.79–66.92) 102545 (43772–208753) 32.04 (13.68–65.23) −0.11 (−0.16–0.07)
 65–69 years 39781 (17896–76295) 32.18 (14.48–61.72) 84201 (37878–164251) 30.53 (13.73–59.55) −0.13 (−0.19–0.06)
 70–74 years 26027 (11669–48523) 30.74 (13.78–57.31) 60571 (26840–112519) 29.43 (13.04–54.66) −0.09 (−0.15–0.03)
 75–79 years 17405 (7805–32482) 28.28 (12.68–52.77) 35293 (16013–65348) 26.76 (12.14–49.55) −0.09 (−0.14–0.03)
 80–84 years 9102 (4015–17000) 25.73 (11.35–48.06) 20816 (9228–39364) 23.77 (10.54–44.94) −0.15 (−0.21–0.1)
 85–89 years 3393 (1465–6730) 22.45 (9.69–44.54) 9255 (4094–17727) 20.24 (8.95–38.77) −0.26 (−0.3–0.22)
 90–94 years 780 (317–1597) 18.2 (7.4–37.26) 2914 (1222–5926) 16.29 (6.83–33.12) −0.34 (−0.39–0.28)
 95 + years 128 (53–278) 12.62 (5.23–27.33) 619 (260–1321) 11.35 (4.76–24.23) −0.27 (−0.39–0.15)
SDI region
 High-middle SDI 305219 (132610–581718) 27.81 (12.15–53.29) 371029 (167790–710273) 26.27 (11.65–49.92) −0.19 (−0.2–0.18)
 High SDI 232729 (104423–442471) 24.88 (11.09–47.23) 271471 (124443–518668) 23.06 (10.27–43.91) −0.22 (−0.27–0.17)
 Low-middle SDI 316030 (136928–605953) 30.84 (13.76–58.82) 555887 (246486–1059748) 29.18 (13.04–55.36) −0.05 (−0.17–0.07)
 Low SDI 133975 (58363–251648) 32.19 (14.47–59.74) 305981 (133494–574357) 30.97 (14.01–57.73) −0.08 (−0.14–0.02)
 Middle SDI 453446 (193127–862544) 26.86 (11.73–51.62) 691532 (311277–1329673) 26.77 (11.97–51.3) 0.06 (−0.01–0.13)
GBD region
 Advanced Health System 396361 (178393–750833) 28.51 (12.75–54.05) 438115 (199848–831430) 26.48 (11.85–50.34) −0.22 (−0.25–0.2)
 Africa 163137 (69389–309794) 30.14 (13.4–57.13) 357256 (154570–681420) 28.44 (12.78–53.93) −0.19 (−0.21–0.18)
 African Region 126636 (54036–241131) 29.43 (13.14–55.43) 289860 (125401–551103) 28.06 (12.64–52.96) −0.16 (−0.18–0.15)
 America 194309 (84850–369941) 27.26 (12.01–51.99) 296068 (133759–564408) 27.3 (12.15–52.05) 0.06 (0.05–0.08)
 Andean Latin America 14953 (6650–27599) 42.59 (19–78.75) 28104 (12465–53214) 41.91 (18.6–79.06) −0.13 (−0.16–0.1)
 Asia 792751 (338172–1514882) 25.54 (11.16–49.02) 1243504 (557126–2364591) 25.63 (11.42–48.75) 0.1 (0.01–0.19)
 Australasia 6322 (2784–12126) 29.26 (12.91–56.26) 8576 (3829–16539) 25.38 (11.24–48.41) −0.15 (−0.37–0.07)
 Basic Health System 585513 (251664–1116812) 25.44 (11.08–48.9) 841309 (378170–1629683) 25.43 (11.3–48.79) −0.01 (−0.05–0.02)
 Caribbean 12605 (5546–24147) 36.7 (16.25–70.09) 16883 (7615–32039) 34.3 (15.46–64.98) −0.16 (−0.19–0.13)
 Central Africa 17209 (7266–33426) 31.48 (13.82–59.92) 46627 (19909–88722) 32.17 (14.02–60.57) 0.04 (0–0.08)
 Central Asia 23535 (10362–44426) 36.22 (16.11–68.83) 34400 (15253–65176) 35.58 (15.67–67.47) −0.08 (−0.12–0.05)
 Central Europe 50008 (22444–94367) 38.47 (17.19–72.29) 43207 (19820–82398) 35.05 (15.67–66.02) −0.24 (−0.28–0.2)
 Central Latin America 44329 (19189–83175) 29.71 (13.19–55.95) 75234 (33613–143277) 28.5 (12.73–54.11) 0.08 (0–0.17)
 Central Sub-Saharan Africa 13849 (5837–26849) 30.71 (13.48–58.54) 37074 (15716–70220) 31.31 (13.62–58.83) 0.03 (−0.01–0.07)
 Commonwealth High Income 33926 (15467–65086) 28.21 (12.79–54.19) 41138 (18770–78858) 25.4 (11.5–48.69) −0.27 (−0.35–0.18)
 Commonwealth Low Income 55109 (23503–104992) 31.86 (13.95–59.74) 110329 (47879–209204) 30.24 (13.31–56.86) −0.21 (−0.23–0.19)
 Commonwealth Middle Income 318854 (139314–605645) 30.62 (13.66–57.71) 601566 (267151–1136076) 28.76 (12.89–54.1) 0.03 (−0.16–0.22)
 East Asia 250909 (105316–475098) 19.39 (8.36–36.81) 298908 (135110–582540) 19.21 (8.53–36.69) −0.04 (−0.08–0)
 East Asia & Pacific—WB 421091 (180130–798786) 21.78 (9.45–41.64) 544173 (243459–1064732) 21.75 (9.6–41.9) −0.03 (−0.07–0.01)
 Eastern Africa 47239 (20457–90034) 32.53 (14.64–61.6) 108333 (47174–205733) 31.12 (14.06–58.68) −0.21 (−0.24–0.18)
 Eastern Europe 72439 (32572–140967) 30.51 (13.65–58.91) 67486 (30226–131279) 29.82 (13.21–57.55) −0.08 (−0.11–0.06)
 Eastern Mediterranean Region 103454 (44472–198402) 31.32 (13.89–60.01) 222833 (96751–427831) 30.37 (13.52–57.93) −0.11 (−0.12–0.1)
 Eastern Sub-Saharan Africa 52181 (22646–98681) 33.17 (14.94–62.36) 117643 (51384–222922) 30.99 (14.01–58.31) −0.23 (−0.25–0.21)
 Europe 289789 (131002–549213) 34.14 (15.29–64.63) 297722 (135421–564142) 31.86 (14.33–60.52) −0.22 (−0.23–0.21)
 Europe & Central Asia—WB 305769 (137851–578990) 34.24 (15.32–64.84) 323401 (147097–612453) 32.2 (14.43–61.18) −0.19 (−0.2–0.18)
 European Region 308782 (139155–584622) 34.3 (15.34–64.95) 328233 (149325–621584) 32.27 (14.46–61.32) −0.19 (−0.2–0.18)
 High-income Asia Pacific 30523 (13438–60140) 16.65 (7.35–32.57) 25188 (11385–49313) 14.49 (6.49–28.15) −0.4 (−0.48–0.33)
 High-income North America 58934 (26265–114662) 19.98 (8.83–38.85) 73976 (33596–143321) 18.85 (8.43–36.61) −0.07 (−0.16–0.02)
 Latin America & Caribbean—WB 136697 (59481–261068) 33.21 (14.64–63.13) 223336 (99615–427004) 32.24 (14.32–61.57) −0.04 (−0.06–0.01)
 Limited Health System 420831 (182503–799656) 30.78 (13.77–58.05) 819805 (363621–1551755) 29.26 (13.12–55.12) 0 (−0.14–0.15)
 Middle East & North Africa—WB 77329 (33124–148106) 33.66 (14.93–64.57) 155060 (68135–298839) 32.2 (14.31–62.11) −0.15 (−0.17–0.13)
 Minimal Health System 38694 (16413–73869) 34.84 (15.28–65.85) 96671 (40862–183230) 33.93 (14.81–63.44) −0.08 (−0.1–0.07)
 North Africa and Middle East 106153 (45221–203126) 34.79 (15.3–66.65) 208354 (90480–398422) 33.22 (14.66–63.7) −0.18 (−0.22–0.14)
 North America 58943 (26270–114681) 19.98 (8.83–38.86) 73986 (33601–143340) 18.85 (8.43–36.61) −0.07 (−0.16–0.02)
 Northern Africa 35854 (15180–68683) 32.44 (14.32–62.57) 61733 (27109–118829) 29.69 (13.16–57.39) −0.28 (−0.32–0.23)
 Oceania 2368 (1008–4504) 39.55 (17.07–73.66) 5151 (2201–9563) 39.08 (17.08–72.46) −0.02 (−0.04–0)
 Region of the Americas 194309 (84850–369941) 27.26 (12.01–51.99) 296068 (133759–564408) 27.3 (12.15–52.05) 0.06 (0.05–0.08)
 South-East Asia Region 372199 (161669–710367) 31.63 (14.08–59.85) 642534 (286068–1221133) 29.96 (13.36–56.7) 0.02 (−0.17–0.2)
 South Asia 303996 (132371–576696) 31.63 (14.08–59.52) 561162 (249820–1057274) 29.9 (13.39–56.12) 0.06 (−0.14–0.26)
 South Asia—WB 312965 (136187–594064) 31.7 (14.12–59.68) 578636 (257732–1090734) 30.02 (13.45–56.38) 0.06 (−0.14–0.25)
 Southeast Asia 136642 (59512–264319) 31.28 (13.74–60.31) 213451 (93488–420515) 29.3 (12.82–57.09) −0.3 (−0.41–0.2)
 Southern Africa 25089 (10735–47614) 30.72 (13.6–58.19) 48278 (20831–91915) 28.3 (12.63–53.71) −0.12 (−0.17–0.07)
 Southern Latin America 19860 (8709–37591) 40.61 (17.85–77.16) 29887 (13562–56603) 41.1 (18.54–78.13) 0.04 (−0.04–0.12)
 Southern Sub-Saharan Africa 12189 (5267–23278) 25.98 (11.52–49.6) 19806 (8734–37942) 24.43 (10.9–46.77) −0.08 (−0.12–0.04)
 Sub-Saharan Africa—WB 127709 (54541–243096) 29.59 (13.22–55.8) 296370 (128045–563993) 28.24 (12.72–53.24) −0.16 (−0.17–0.15)
 Tropical Latin America 45401 (19695–88291) 30.97 (13.64–60.24) 73823 (32873–144478) 30.51 (13.45–59.27) −0.07 (−0.12–0.03)
 Western Africa 37746 (16285–71914) 25.46 (11.39–48.03) 92286 (40056–177088) 24.08 (10.8–45.47) −0.2 (−0.21–0.19)
 Western Europe 143434 (65036–272520) 34.01 (15.35–64.83) 153042 (70258–290905) 30.99 (14.07–59.26) −0.29 (−0.34–0.24)
 Western Pacific Region 331751 (141651–626456) 20.5 (8.89–38.9) 411822 (185734–798782) 20.49 (9.05–39.13) −0.02 (−0.06–0.01)
 Western Sub-Saharan Africa 42562 (18262–81406) 26.04 (11.66–49.01) 106709 (46121–204748) 24.87 (11.18–46.77) −0.17 (−0.19–0.16)
 World Bank High Income 291256 (130812–551055) 27.32 (12.24–51.66) 330466 (150965–628057) 25.15 (11.25–47.74) −0.24 (−0.29–0.2)
 World Bank Low Income 90915 (38947–173155) 32.42 (14.34–60.84) 206653 (88666–389952) 31.63 (14.09–59.51) −0.07 (−0.07–0.06)
 World Bank Lower Middle Income 533102 (231228–1019662) 30.97 (13.86–58.83) 969257 (430806–1845846) 29.34 (13.12–55.61) −0.07 (−0.19–0.05)
 World Bank Upper Middle Income 523819 (226148–993944) 24.92 (10.83–47.6) 686813 (309611–1324772) 24.62 (10.87–47.05) −0.02 (−0.05–0)
Country
 Afghanistan 3313.24 (1377.16371.9) 38.21 (16.572.75) 10199.54 (4381.9219231.29) 38.1 (16.7271.02) −0.014 (−0.0640.035)
 American Samoa 16.45 (6.9331.28) 36.77 (16.1569.18) 18.93 (8.2235.85) 37.23 (16.3369.91) 0.355 (0.3210.388)
 Angola 2564.6 (1061.785005.57) 30.31 (13.0858.01) 7869.8 (3215.215434.98) 29.24 (12.655.17) −0.251 (−0.290-0.212)
 Antigua and Barbuda 21.32 (9.3640.14) 35.67 (15.7267.49) 33.49 (14.6764.67) 34.18 (14.9565.8) 0.224 (0.2100.237)
 Arab Republic of Egypt 16049.94 (6882.8131220.26) 31.82 (13.9961.63) 30625.6 (13266.2758508.82) 30.2 (13.2157.13) −0.152 (−0.220-0.085)
 Argentine Republic 13179.41 (5774.1324840.04) 40.36 (17.7176.36) 19777.4 (8792.637144.42) 40.88 (18.1276.52) 0.338 (0.3140.362)
 Australia 5499.14 (2428.9710562.47) 30.58 (13.558.84) 7285.09 (3245.5613957.02) 25.86 (11.3949.35) −0.188 (−0.4830.107)
 Bangladesh 28428.34 (12015.1955560.55) 31.47 (13.7259.44) 50691.82 (22009.9296656.45) 30.29 (13.2657.52) 0.527 (0.5090.545)
 Barbados 93.51 (41.27178.55) 35.61 (15.6868.19) 114.85 (51.86219.6) 35.19 (15.6367.16) 0.092 (0.0680.115)
 Belize 60.76 (26.24115.56) 37.58 (16.5771.61) 135.71 (61.84266.06) 30.77 (14.0460.42) 0.079 (−0.0160.174)
 Benin 1228.53 (510.262361.7) 32.27 (13.7960.91) 3608.39 (1532.937045.78) 31.57 (13.8460) 0.112 (0.0850.139)
 Bermuda 22.26 (9.6242.71) 34.34 (14.8765.43) 22.62 (10.1442.71) 32.81 (14.3162.57) −0.194 (−0.211-0.177)
 Bhutan 168.77 (70.55329.74) 30.89 (13.2658.4) 227.92 (99.9440.33) 28.79 (12.6855.27) 0.403 (0.3840.423)
 Bolivarian Republic of Venezuela 6510.89 (2890.2512525.54) 38.17 (17.2672.96) 10629.76 (4746.3820353.95) 38.07 (16.9473.26) 0.404 (0.3760.432)
 Bosnia and Herzegovina 2094.09 (940.053947.89) 44.46 (19.9283.77) 1347.26 (602.12529.44) 38 (16.7370.69) −0.434 (−0.452-0.416)
 Botswana 304.34 (130.79586.4) 27.04 (11.7750.96) 623.95 (267.271182.47) 25.3 (11.0647.77) 0.414 (0.3850.443)
 Brunei Darussalam 43.38 (18.7783.87) 16.1 (7.0231.36) 81.6 (35.62154.76) 16.35 (7.1831.02) 0.273 (0.2480.298)
 Burkina Faso 2389.57 (1027.144669.87) 31.61 (13.7760.97) 5848.24 (2483.1811273.82) 30.77 (13.5557.99) −0.185 (−0.278-0.092)
 Burundi 1654.94 (698.823169.99) 36.33 (15.8268.42) 4198.99 (1799.917920.23) 36.95 (16.2369.36) 0.177 (0.1490.204)
 Cabo Verde 95.54 (40.7183.56) 32.18 (14.0461.13) 176.13 (76.45339.91) 29.96 (13.1457.37) 0.543 (0.5140.571)
 Cameroon 2660.79 (1130.855168.73) 31.04 (13.5159.5) 8757.12 (3679.2116802.79) 31.28 (13.5458.56) 0.132 (0.0860.177)
 Canada 5677.35 (2502.8210994.11) 19.28 (8.4737.02) 7478.66 (3295.714569.35) 18.51 (8.1235.72) −0.135 (−0.159-0.111)
 Central African Republic 724.15 (305.261398.84) 31.83 (13.8460.29) 1554.43 (658.472949.63) 32.27 (14.0460.84) 0.215 (0.1990.230)
 Chad 1576.83 (669.762965.48) 32.87 (14.4162.28) 4401.35 (1899.48603.01) 31.81 (14.2761.16) −0.249 (−0.283-0.216)
 Commonwealth of Dominica 25.3 (11.148.05) 36.84 (16.4269.77) 25.57 (11.350.02) 35.33 (15.569.17) 0.318 (0.2950.341)
 Commonwealth of the Bahamas 97.95 (42.77186.1) 38.22 (16.7772.23) 157.45 (71.73297.28) 37.22 (16.9269.96) 0.021 (−0.0550.097)
 Comoros 126.24 (58.04234.99) 32.13 (1560.77) 213.95 (95.25432.05) 28.78 (12.9457.5) 0.345 (0.2820.408)
 Congo 609.61 (260.061178.71) 29.81 (13.1157.04) 1508.7 (634.942841.97) 29.49 (12.9454.95) 0.182 (0.1370.226)
 Cook Islands 6.84 (2.8512.85) 37.35 (16.0669.25) 6.73 (2.9613.1) 36.06 (15.7569.84) 0.167 (0.1490.185)
 Czech Republic 4180.15 (1855.077854.68) 38.63 (17.0572.21) 4106.23 (1874.657789.87) 36.87 (16.3369.93) −0.228 (−0.297-0.160)
 Democratic People’s Republic of Korea 2640.14 (1076.175077.22) 12.51 (5.1524.36) 3890.78 (1697.997525.22) 13.63 (5.8726.86) 0.128 (0.0560.199)
 Democratic Republic of the Congo 9608.07 (4052.1318633.84) 30.88 (13.5558.81) 25282.39 (10902.7248000) 32.23 (14.261.12) 0.731 (0.6190.843)
 Democratic Republic of Timor-Leste 263.26 (113.21499.91) 38.93 (17.2373.9) 475.64 (202.86905.11) 36.61 (15.969.31) 0.289 (0.2490.329)
 Democratic Socialist Republic of Sri Lanka 5595.37 (2389.4710653.71) 33.17 (14.3763.07) 7102.41 (3122.9313738.71) 30.22 (13.3458.11) 0.237 (0.1250.349)
 Djibouti 118.7 (53.11227.12) 31.77 (14.3459.77) 351.84 (159.5679.91) 27.68 (12.6254.36) −0.129 (−0.164-0.093)
 Dominican Republic 2457.88 (1071.264676.57) 37.03 (16.2569.34) 3928.51 (1720.737555.95) 34.72 (15.1866.59) 0.073 (0.0130.134)
 Eastern Republic of Uruguay 1308.74 (580.362444.7) 40.68 (17.9676.36) 1472.31 (670.742723.87) 39.9 (17.8973.87) 0.164 (0.1390.189)
 Equatorial Guinea 106.05 (45.47198.76) 30.97 (13.6858.41) 380.54 (162.57741.47) 27.09 (11.8851.44) 0.132 (0.1170.147)
 Eritrea 1134.64 (487.552168.06) 39.96 (17.6474.76) 2485.27 (1063.344698.93) 40.59 (17.7675.78) −0.195 (−0.345-0.044)
 Eswatini 181.07 (77350.25) 27.44 (11.8752.86) 291.35 (127.92570.16) 26.19 (11.4949.82) 0.436 (0.3970.476)
 Ethiopia 12163.38 (5536.6623426.11) 29.6 (13.6356.87) 27002.33 (12255.0252168.2) 27.59 (12.5353.09) 0.410 (0.3990.421)
 Federal Republic of Germany 29129.08 (12692.7956374.46) 32.23 (13.9462.07) 25405.38 (11432.9549370.04) 27.82 (12.5953.92) 0.090 (0.0800.099)
 Federated States of Micronesia 37.17 (15.8870.33) 40.15 (17.774.73) 40.86 (17.577.41) 39.37 (17.2174.79) −0.625 (−0.678-0.573)
 Federative Republic of Brazil 43976.98 (19083.9285659.62) 30.76 (13.5559.92) 70853.11 (31633.8138987.16) 30.15 (13.3158.68) 0.371 (0.3550.387)
 French Republic 25946.52 (11935.8448894.31) 41.75 (1979.35) 28891.45 (13319.1154683.03) 38.18 (17.0373.09) 0.238 (0.1870.290)
 Gabon 236.6 (101.42447.47) 27.6 (12.1452.04) 478.45 (205901.94) 27.68 (12.1352.15) −0.058 (−0.085-0.030)
 Gambia 256.65 (109.04496.78) 31.66 (13.8759.94) 674.84 (283.111296.94) 31.65 (13.8759.92) 0.247 (0.2220.273)
 Georgia 2037.67 (914.973847.39) 35.66 (15.9467.06) 1351.43 (608.832632.2) 35.57 (15.6367.58) 0.141 (0.1050.177)
 Ghana 3501.54 (1484.776746.73) 27.52 (11.9252.74) 8451.96 (3606.3916651.56) 26.38 (11.5851.31) −0.041 (−0.1420.059)
 Grand Duchy of Luxembourg 147.49 (65.64281.73) 34.31 (15.0465.04) 242.65 (108.94461.22) 32.66 (14.661.77) 0.084 (0.0330.136)
 Greenland 11.03 (4.7521.21) 18.44 (8.0935.9) 10.65 (4.6620.78) 17.8 (7.7334.19) −0.068 (−0.112-0.024)
 Grenada 29.2 (12.9555.2) 37.18 (16.3971.49) 38.76 (17.0474.67) 35.13 (15.3267.41) −0.069 (−0.104-0.034)
 Guam 48.51 (20.7691.83) 35.46 (15.4567.64) 57.73 (24.89105.38) 35.07 (15.0664.36) 0.373 (0.3200.426)
 Guinea 1574.45 (663.483039.86) 32.02 (13.9560.71) 3630.57 (1517.056917.43) 31.89 (13.7959.69) 0.084 (0.0680.100)
 Guinea-Bissau 331.04 (141.53629.2) 39.63 (17.2275.14) 688.92 (291.691326.22) 38.5 (17.0274.89) 0.036 (0.0100.061)
 Hashemite Kingdom of Jordan 1214.05 (503.222373.55) 36.92 (16.0769.87) 4453.07 (1929.658414.09) 35.66 (15.7267.81) 0.102 (0.0720.132)
 Hellenic Republic 4771.67 (2202.869130.42) 42.51 (19.5381.83) 4406.29 (1960.728257.85) 36.89 (16.3970.78) 0.255 (0.2080.302)
 Hungary 4024.1 (1757.587807.2) 36.84 (16.0670.73) 3481.57 (1564.316646.32) 34.41 (15.3566.05) −0.161 (−0.231-0.091)
 Independent State of Papua New Guinea 1483.74 (632.182822.66) 39.84 (17.1173.83) 3845.39 (1641.557139.97) 39.2 (17.1772.47) −0.240 (−0.275-0.206)
 Independent State of Samoa 60.56 (25.54115.57) 39.55 (17.2173.17) 77.86 (33.23147.79) 38.97 (16.974.54) 0.106 (0.0790.132)
 India 246550.85 (108263.21467242.06) 32.42 (14.4660.92) 446628.52 (199199.01841621.74) 30.56 (13.6957.41) 0.033 (0.0230.044)
 Ireland 1351.13 (593.142589.51) 36.79 (16.171.09) 1835.57 (820.533412.58) 33.44 (14.8962.46) 0.583 (0.3380.827)
 Islamic Republic of Iran 15501.48 (6839.1629842.94) 31.37 (14.1159.97) 27477.3 (12393.853128.67) 30.5 (13.758.85) −0.092 (−0.130-0.055)
 Ivoire 3122.73 (1332.656080.62) 30.9 (13.4158.83) 7523.32 (3135.4714359.37) 30.47 (13.2957.2) 0.483 (0.2480.718)
 Jamaica 824.18 (362.221543.92) 36.86 (16.0368.89) 1082.31 (475.892039.03) 35.73 (15.867.51) 0.361 (0.3490.373)
 Japan 19394.84 (8634.1737401.24) 14.97 (6.6928.78) 12817.24 (5755.4625239.56) 11.7 (5.2622.92) −1.376 (−1.554-1.198)
 Kenya 5049.55 (2202.599703.95) 26.51 (11.8750.65) 11844.2 (5243.122828.93) 25.03 (11.2647.77) 0.284 (0.2550.313)
 Kingdom of Bahrain 172.92 (72.94338.41) 34.68 (15.1367.88) 565.43 (241.771086.35) 33.52 (14.4964.65) 0.297 (0.2610.332)
 Kingdom of Belgium 3018.53 (1347.165701.2) 27.29 (12.0651.69) 3364.93 (1492.736357.34) 26.16 (11.5749.08) −0.136 (−0.189-0.083)
 Kingdom of Cambodia 3357.4 (1431.246389.4) 38.49 (16.7272.16) 6122.5 (2717.4111807.61) 36.27 (16.1869.94) 0.441 (0.3480.535)
 Kingdom of Denmark 1123.62 (503.952157.6) 19.48 (8.7237.88) 1323.8 (596.52664.41) 21.68 (9.8143.75) −0.128 (−0.211-0.046)
 Kingdom of Norway 1383.14 (626.292637.12) 29.62 (13.2556.82) 1758.98 (802.243387.94) 28.62 (12.9155.37) 0.506 (0.3120.702)
 Kingdom of Spain 16429.19 (7268.1830985.41) 39.07 (17.0874.09) 18798.07 (8508.0135749.59) 35.01 (15.5867.84) −0.174 (−0.311-0.038)
 Kingdom of Sweden 2580.13 (11254807.33) 27.95 (12.0552.38) 3502.8 (1566.616545.12) 30.18 (13.2357.35) 0.431 (0.2930.569)
 Kingdom of Thailand 18516.95 (7979.1334994.13) 32.26 (13.9660.55) 22570.37 (9932.745220.95) 30.27 (13.1759.77) 0.093 (0.0710.116)
 Kingdom of the Netherlands 4821.6 (2188.19302.12) 29.66 (13.4556.83) 4014.82 (1852.617924.88) 22.29 (10.1844.28) −0.633 (−0.829-0.436)
 Kingdom of Tonga 35.27 (15.2168.12) 39.63 (17.5374.45) 38.5 (16.4873.89) 38.68 (16.9373.83) 0.040 (0.0190.061)
 Kyrgyz Republic 1510.71 (662.682864.57) 36.76 (16.2770.78) 2477.96 (1071.064643.37) 37.09 (16.1369.44) 0.189 (0.0860.292)
 Lao People's Democratic Republic 1178.28 (504.332258.83) 32.48 (14.2962.14) 2151.25 (911.764133.72) 29.55 (12.7156.71) 0.210 (0.1550.264)
 Lebanon 1028.27 (4451983.19) 36.23 (15.8468.87) 2043.29 (908.623838.44) 35.07 (15.4765.94) 0.188 (0.1730.203)
 Lesotho 381.38 (163.61732.24) 29.38 (12.9355.53) 509.68 (214.25978.42) 27.73 (12.0152.99) 0.242 (0.2070.277)
 Liberia 650.67 (266.951233.68) 31.95 (13.5259.08) 1608.69 (689.793089.72) 32.4 (14.1661.3) 0.214 (0.1610.267)
 Libya 1285.33 (545.12499.52) 34.1 (14.8166.26) 2666.89 (1177.615041.52) 35.96 (15.9167.16) 0.685 (0.6460.724)
 Madagascar 5203.23 (22589803.84) 49.34 (21.6692.77) 11409.27 (5015.8121364.85) 45 (19.9383.93) −0.302 (−0.451-0.152)
 Malawi 2962.56 (1258.245571.61) 36.56 (16.0869.13) 6246.34 (2669.7811969.58) 36.09 (15.8767.89) 0.118 (0.0690.167)
 Malaysia 4412.44 (1855.428388.57) 26.34 (11.3750.91) 8107.25 (3502.3915675.34) 24.09 (10.4746.39) 0.078 (0.0240.132)
 Mali 2300.33 (974.964354.6) 32.88 (14.4160.87) 6211.25 (2604.1811898.51) 31.75 (13.8459.69) −0.172 (−0.199-0.145)
 Mauritania 545.18 (233.681032.57) 31.61 (13.7859.34) 1198.11 (511.592320.92) 30.98 (13.559.69) −0.037 (−0.0800.007)
 Mauritius 350.1 (150.51670.95) 31.72 (13.761.49) 415.83 (185.15788.37) 29.58 (12.8855.6) 0.121 (0.1080.134)
 Monaco 11.76 (5.2121.99) 32.44 (14.1460.3) 13.72 (6.1226.11) 30.66 (13.4458.87) −0.225 (−0.266-0.184)
 Mongolia 712.18 (309.11366.37) 37.07 (16.3671.55) 1158.52 (504.662276.45) 35.38 (15.6369.2) 0.167 (0.0240.310)
 Montenegro 279.05 (125.91532.41) 43.32 (19.5582.4) 258.14 (112.7481.12) 39.13 (16.9472.93) −0.178 (−0.210-0.147)
 Morocco 6966.37 (3139.0613548.67) 29.04 (13.156.04) 7287.55 (3256.3314142.81) 19.15 (8.5437.4) −1.013 (−1.332-0.693)
 Mozambique 5130.82 (2217.399613.93) 45.74 (20.2985.52) 9563.2 (4096.4218149.25) 36.38 (15.7466.24) −0.469 (−0.596-0.342)
 Namibia 362 (158684.99) 30.11 (13.0656.46) 701.71 (301.891341.63) 29.71 (12.9356.72) 0.449 (0.3290.569)
 Nauru 3.4 (1.456.5) 36.83 (16.0969.15) 3.96 (1.77.42) 37.41 (16.2768.96) 0.190 (0.1000.280)
 Nepal 4972.18 (2081.379409.49) 30.16 (13.1256.8) 8636.4 (3762.8316181.06) 27.83 (12.2352.11) 0.221 (0.1160.326)
 New Zealand 823.13 (361.641586.69) 22.75 (9.9943.8) 1290.95 (572.652519.58) 23.01 (10.1244.53) 0.154 (−0.0130.320)
 Niger 2189.95 (919.874161.52) 34.99 (15.2565.53) 6765.09 (2847.6412957.93) 34.72 (15.3864.81) −0.417 (−0.553-0.281)
 Nigeria 16043.35 (6974.231228.86) 20.35 (9.0839.63) 39209.24 (17226.5177223.71) 18.93 (8.4836.94) −0.253 (−0.302-0.203)
 Niue 0.85 (0.371.59) 38.48 (16.7772.57) 0.65 (0.291.22) 37.49 (16.5869.61) 0.128 (0.0880.169)
 North Macedonia 886.71 (391.211674.51) 43.21 (19.1481.58) 930.43 (416.551741.68) 38.77 (17.1173.05) −0.028 (−0.0680.011)
 Northern Mariana Islands 16.65 (732.21) 35.61 (15.3367.61) 18.44 (7.8335.17) 36.01 (15.4168.27) 0.185 (0.1250.245)
 Oman 657.4 (283.231244.5) 37.17 (16.5170.2) 1771.74 (795.323362.78) 36.11 (16.3968.52) 0.258 (0.1920.323)
 Pakistan 23876.24 (10306.7646196.06) 25.13 (11.1347.81) 54976.99 (23948.1104252.85) 25.35 (11.1747.86) 0.270 (0.1890.352)
 Palau 5.81 (2.5110.84) 37.73 (16.4170.7) 7.34 (3.2414.04) 37.21 (16.3270.23) 0.171 (0.1340.208)
 Palestine 564.79 (242.521105.93) 32.82 (14.3964.12) 1536.27 (655.233011.52) 31.32 (13.9561.03) 0.395 (0.3190.471)
 People's Democratic Republic of Algeria 8131.93 (3383.0915625.39) 35.86 (15.6168.8) 15541.43 (6719.3530022.65) 35.34 (15.3468.33) 0.200 (0.1020.298)
 People's Republic of China 245424.83 (103102.3464520.75) 19.62 (8.4637.24) 291828.69 (131906.61568107.54) 19.43 (8.6437.07) 0.000 (−0.0940.095)
 Plurinational State of Bolivia 2474.39 (1084.964653.68) 43.27 (19.1981.15) 4981.07 (2197.039418.43) 42.27 (18.6479.79) 0.297 (0.2820.313)
 Portuguese Republic 3367.11 (1518.166408.59) 30.36 (13.5557) 3600.42 (1610.347009.92) 28.95 (12.6154.97) −0.051 (−0.096-0.005)
 Principality of Andorra 20.84 (9.1939.86) 34.05 (15.0765.4) 34 (15.1565.3) 32.82 (14.6462.18) 0.047 (0.0110.084)
 Puerto Rico 1271.98 (561.762406.32) 34.69 (15.3565.59) 1201.75 (540.522264.11) 33.69 (14.7764.31) 0.108 (0.1000.116)
 Qatar 149.13 (64.2288.33) 32.77 (14.562.78) 1092.6 (467.82140.77) 32.17 (13.8562.7) 0.312 (0.2670.357)
 Republic of Albania 1327.02 (584.242490.72) 41.04 (18.276.78) 1096.26 (487.822074.38) 38.29 (16.7671.52) 0.081 (0.0460.116)
 Republic of Armenia 1241.77 (538.242356.58) 36.64 (15.8770.26) 1146.37 (512.752186.29) 35.59 (15.5367.5) 0.123 (0.0320.214)
 Republic of Austria 2612.94 (1168.174926.13) 30.22 (13.2756.31) 2987.85 (1334.625811.59) 28.94 (12.8155.91) −0.010 (−0.0540.034)
 Republic of Azerbaijan 2531.76 (1106.624897.73) 35.74 (15.8469.34) 3960.39 (1769.937661.72) 35 (15.5967.74) 0.234 (0.1320.336)
 Republic of Belarus 3411.42 (1488.076641.27) 31.31 (13.5860.26) 3089.43 (1346.645789.01) 30.8 (13.458.09) −0.012 (−0.0920.068)
 Republic of Bulgaria 3854.28 (1708.987226.6) 42.07 (18.4878.44) 2857.17 (12945430.72) 39.21 (17.474.1) −0.204 (−0.261-0.146)
 Republic of Chile 5370.71 (2337.4310245.37) 41.2 (18.0178.44) 8636.02 (4065.3416511.61) 41.74 (19.6779.63) 0.252 (−0.0670.572)
 Republic of Colombia 10012.04 (4328.6218570.93) 32.66 (14.2860.55) 16431.36 (7277.1730999.78) 31.28 (13.8258.85) 1.298 (0.9011.696)
 Republic of Costa Rica 1004.15 (439.151855.14) 35.81 (15.9367.34) 1749.78 (763.763278.1) 34.22 (14.9763.95) 0.364 (0.3300.398)
 Republic of Croatia 2268.22 (1007.14336.04) 44.33 (19.6683.45) 1794.04 (813.073467.63) 39.94 (17.7875.4) −0.205 (−0.249-0.160)
 Republic of Cuba 4166.72 (1824.188064.71) 36.51 (15.9670.2) 4340.4 (1926.768326.08) 35.26 (15.3368.02) 0.128 (0.0080.247)
 Republic of Cyprus 288.52 (128.81543.04) 35.64 (15.9867.35) 530.72 (240.431025.11) 33.99 (15.2265.95) 0.213 (0.1970.229)
 Republic of Ecuador 3917.42 (1712.587304.82) 42.23 (18.5178.44) 7687.76 (3414.2914498.34) 42.06 (18.7779.37) −0.089 (−0.2150.037)
 Republic of El Salvador 1726.77 (736.083250.63) 36.8 (16.2169.15) 2280.65 (1007.154354.96) 35.2 (15.5267.14) 0.327 (0.2920.363)
 Republic of Estonia 353.03 (154.38686.92) 21.84 (9.4842.38) 271.99 (119.67534.78) 20.55 (8.9239.81) −0.323 (−0.390-0.255)
 Republic of Fiji 281.59 (118.64534.53) 38.79 (16.8172.65) 353.21 (154.74647.42) 37.98 (16.769.66) 0.033 (−0.0790.146)
 Republic of Finland 1306.44 (571.792414.55) 23.71 (10.444.27) 1390.03 (615.852654.85) 22.37 (9.6743.24) −0.103 (−0.3080.103)
 Republic of Guatemala 2463.56 (1076.454680.75) 36.3 (16.0867.53) 5436.95 (2327.1510313.97) 35.21 (15.4466.53) 0.538 (0.5010.574)
 Republic of Guyana 273.02 (119.97520.68) 37.61 (16.8471.63) 275.24 (119.08528.9) 35.35 (15.3167.22) 0.157 (0.1300.183)
 Republic of Haiti 2162.79 (980.294187.83) 38.63 (17.8374.91) 4226.11 (1954.988315.76) 33.58 (15.5266.27) 0.074 (0.0110.138)
 Republic of Honduras 1432.51 (631.532698.68) 36.95 (16.4669.19) 3534.59 (1547.776675.01) 36.1 (15.8768.44) 0.438 (0.4300.445)
 Republic of Iceland 106.45 (47.77201.95) 40.77 (18.1976.98) 125.69 (57.28246.51) 33.77 (15.3765.81) −0.540 (−0.592-0.488)
 Republic of Indonesia 54753.88 (23832.25106496.4) 31.66 (14.0561.24) 88589.14 (38541.35174436.19) 30.3 (13.2859.19) 0.106 (−0.1000.313)
 Republic of Iraq 5757.1 (2460.7110966.76) 36.07 (16.1368.21) 14190.94 (6038.1427148.45) 35.01 (15.4365.49) 0.193 (0.1570.229)
 Republic of Italy 19132.93 (8509.8636194.92) 30.03 (13.0756.74) 19701.25 (8889.0637014.69) 28.18 (12.5153.58) −0.112 (−0.136-0.088)
 Republic of Kazakhstan 5689.97 (2495.9110777.05) 35.3 (15.5167.06) 6578.88 (2873.1512691.89) 34.36 (15.0366.87) 0.052 (−0.0500.155)
 Republic of Kiribati 27.31 (11.7350.91) 40.1 (17.4575.43) 47.46 (20.589.55) 40.4 (17.7575.74) 0.248 (0.2220.273)
 Republic of Korea 10491.37 (4527.8420634.42) 22.03 (9.5943.49) 11321.99 (4939.7622028.49) 20.41 (8.9339.05) −0.313 (−0.332-0.295)
 Republic of Latvia 865.84 (379.611674.41) 31.11 (13.6359.58) 593.34 (265.491173.66) 30.28 (13.1958.87) −0.111 (−0.175-0.047)
 Republic of Lithuania 1418.28 (628.522770.48) 37.22 (16.3672.16) 999.18 (454.371912.24) 34.08 (15.1165.42) −0.250 (−0.336-0.164)
 Republic of Maldives 60.45 (25.66116.67) 32.5 (14.1463.36) 172.8 (74.86329.18) 30.46 (13.3359.1) 0.674 (0.6180.730)
 Republic of Malta 144.02 (63.17279.2) 36.46 (15.9270.79) 174.3 (80.54327.38) 33.88 (15.2563.26) 0.132 (0.0990.166)
 Republic of Moldova 1480.27 (660.722838.82) 32.8 (14.5162.96) 1302.21 (563.182510.39) 32.64 (13.9962.11) 0.275 (0.1810.370)
 Republic of Nicaragua 1182.87 (507.352215.22) 36.9 (16.2369.64) 2394.92 (1067.974571.14) 36 (16.1668.31) 0.519 (0.4850.554)
 Republic of Panama 1009.36 (439.871932.73) 44.45 (19.5884.74) 1795.02 (805.493424.79) 40.99 (18.3978.07) −0.075 (−0.117-0.032)
 Republic of Paraguay 1423.58 (613.882663.57) 39.15 (17.273.42) 2970.32 (1277.185609.15) 40.56 (17.4976.82) 0.620 (0.5760.664)
 Republic of Peru 8560.92 (3791.1715763.23) 42.57 (19.0378.63) 15434.88 (6882.4829279.52) 41.72 (18.6978.82) 0.244 (0.2130.276)
 Republic of Poland 12103.34 (5482.4123362.76) 30.68 (13.8459.33) 12042.02 (5496.0423437.4) 29.26 (13.2456.49) 0.004 (−0.0720.081)
 Republic of Serbia 4250.48 (1882.058091.87) 42.44 (18.7580.17) 3546.47 (1605.816827.62) 36.93 (16.5769.89) 0.264 (−0.1450.675)
 Republic of Singapore 593.64 (257.091143.28) 17.19 (7.4833.07) 967.29 (421.681880.09) 16.33 (7.0732.04) −0.405 (−0.485-0.324)
 Republic of Slovenia 768.76 (343.451490.76) 36.77 (16.5471.35) 749.98 (331.661460.98) 34.58 (14.967.41) −0.215 (−0.276-0.154)
 Republic of Suriname 105.27 (45.35200.6) 27.77 (12.1153.68) 160.15 (69.65312.16) 26.65 (11.6551.2) −0.014 (−0.0530.026)
 Republic of Tajikistan 1716.53 (758.033251.95) 37.05 (16.4870.23) 3613.94 (1559.956804.27) 37.41 (16.3270.36) 0.390 (0.2960.485)
 Republic of the Marshall Islands 15.66 (6.5629.63) 39.69 (17.0675.24) 22.19 (9.4142.01) 39.32 (16.8373.73) 0.412 (0.3840.441)
 Republic of the Philippines 17984.92 (7944.7734736.96) 32.07 (14.3661.43) 35137.91 (15703.4267016.23) 31.36 (14.0959.83) 0.161 (−0.0010.324)
 Republic of the Union of Myanmar 10248.7 (4391.2619787.11) 26.53 (11.4152) 13548.27 (5823.426663.42) 23.51 (10.1746.22) −0.263 (−0.312-0.213)
 Republic of Trinidad and Tobago 417.8 (182.69796.93) 35.68 (15.8267.99) 399.06 (180.94796.64) 27.18 (12.1853.66) −0.696 (−0.755-0.636)
 Republic of Uzbekistan 6911.89 (3044.6813050) 37.09 (16.3570.24) 12323.97 (5414.4723700.54) 35.87 (15.8268.25) 0.353 (0.2360.469)
 Republic of Vanuatu 53.16 (22.63101.98) 39.97 (17.5774.68) 117.79 (50.15222.6) 39.98 (17.4374.87) 0.214 (0.1960.232)
 Romania 11025.78 (4844.9520867.33) 45.61 (20.185.94) 8228.22 (3785.1515402.9) 40.69 (18.2675.23) −0.349 (−0.384-0.315)
 Russian Federation 49705.37 (22453.7596772.43) 31.43 (13.9960.72) 47967.62 (21733.0793381.35) 30.32 (13.5858.61) −0.019 (−0.0870.048)
 Rwanda 2164.8 (925.574111.87) 36.58 (15.8769.06) 4309.91 (1827.098197.6) 34.99 (15.1266.37) 0.264 (0.2420.286)
 Saint Kitts and Nevis 14.1 (6.2326.44) 35.91 (15.8468.98) 22.3 (9.8543.09) 34.04 (14.9264.28) 0.405 (0.3850.425)
 Saint Lucia 46.33 (20.2488.45) 36.68 (16.2170.07) 69.02 (30.93135.05) 35.07 (15.4767.68) 0.499 (0.4720.527)
 Saint Vincent and the Grenadines 50.15 (21.4992.7) 46.74 (20.2686.42) 48.76 (22.1292.44) 40.18 (18.0476.12) −0.265 (−0.418-0.111)
 San Marino 9.17 (4.117.88) 34.34 (15.0967.39) 12.86 (5.8724.75) 33.38 (14.9264.52) −0.010 (−0.0630.042)
 Sao Tome and Principe 32.03 (13.4661.58) 31.79 (14.0561.24) 64.75 (26.77123.97) 31.33 (13.5159.47) 0.273 (0.2290.317)
 Saudi Arabia 5572.17 (2377.6110827.76) 39.46 (17.3275.26) 15667.26 (6798.2930186.85) 38.37 (16.873.05) 0.280 (0.2020.358)
 Senegal 1739.82 (765.923288.72) 27.88 (12.3653.21) 3519.19 (1596.936743.66) 24.04 (10.9846.65) 0.067 (0.0040.131)
 Seychelles 22.13 (9.542.45) 31.17 (13.4360.21) 32.89 (14.4463.52) 29.43 (12.8956.26) 0.100 (0.0480.152)
 Sierra Leone 1357.99 (614.142581.38) 36.93 (16.7370.41) 2392.11 (1065.734654.1) 29.78 (13.6857.52) −0.599 (−0.809-0.387)
 Slovak Republic 2146.68 (953.094042.75) 39.34 (17.4374.05) 2140.28 (961.954044.45) 36.8 (16.2969.88) −0.141 (−0.218-0.064)
 Socialist Republic of Viet Nam 19700.39 (8471.4937676.11) 31.4 (13.7160.66) 28727.19 (12610.1455564.78) 27.54 (12.0853.42) −0.325 (−0.569-0.081)
 Solomon Islands 119.63 (49.72231.69) 40.61 (17.5677.38) 257.55 (108.77488.13) 40.22 (17.4374.92) 0.218 (0.1960.240)
 Somalia 2492.48 (1061.714747.18) 38.68 (17.273.51) 6906.05 (2914.9313197.71) 39.06 (16.7374.13) −0.010 (−0.0420.022)
 South Africa 8955.57 (3873.1116996.24) 26.29 (11.7150.38) 14402.47 (6435.0327542.64) 24.35 (10.9246.56) 0.237 (0.1670.307)
 South Sudan 1686.56 (737.013218.08) 33.76 (15.0164.57) 2935.43 (1217.635731.33) 35.3 (15.4366.25) 0.095 (0.0390.151)
 State of Israel 1993.68 (878.623846.79) 41.12 (18.0679.2) 3738.43 (1697.057161.13) 38.24 (17.2373.7) −0.050 (−0.081-0.019)
 State of Kuwait 574.28 (245.581134.91) 33.87 (14.8265.86) 1711.99 (736.623344.07) 32.99 (14.2663.56) 0.249 (0.2150.283)
 Sudan 6712.07 (2858.7512896.09) 38.63 (16.7573.45) 15144.72 (6529.4928779.39) 37.47 (16.4770.92) 0.047 (−0.0040.098)
 Swiss Confederation 3430.52 (1543.236469.3) 44.84 (19.884.21) 4483.41 (2026.058466.08) 43.5 (19.3382.73) 0.043 (0.0170.070)
 Syrian Arab Republic 4106.05 (1716.287895.96) 37.7 (16.3371.48) 5364.57 (2370.4910351.73) 36.71 (16.4469.77) 0.498 (0.4390.557)
 Taiwan (Province of China) 2843.54 (1197.325367.79) 13.1 (5.625.01) 3188.91 (1386.916162.4) 12.54 (5.2823.99) −0.008 (−0.0610.045)
 Togo 963.91 (405.431815.79) 32.59 (14.1260.01) 1978.12 (894.63839.56) 25.38 (11.5948.64) 0.018 (−0.1290.165)
 Tokelau 0.59 (0.251.1) 39.57 (17.2475.87) 0.54 (0.231.02) 38.28 (16.6872.66) 0.183 (0.1490.218)
 Tunisia 2875.74 (1227.465516.24) 36.64 (15.9670.57) 4413.04 (1905.558351.67) 35.45 (15.3966.37) 0.244 (0.1660.321)
 Turkey 20996.66 (8776.4939868.03) 38.37 (16.2973.08) 32020.63 (14100.960683.92) 35.99 (15.6968.14) 0.047 (−0.1010.195)
 Turkmenistan 1182.15 (510.992245.61) 35.59 (15.6368.03) 1788.51 (782.363461.34) 34.51 (15.1466.52) 0.255 (0.1710.339)
 Tuvalu 3.58 (1.526.69) 40.74 (17.576.03) 4.84 (2.119.06) 39.24 (17.3173.2) 0.189 (0.1710.207)
 Uganda 3450.48 (1477.166721.16) 24.66 (10.7446.48) 8728.43 (3727.4517403.08) 23.56 (10.3345.86) 0.060 (0.0020.118)
 Ukraine 15204.55 (6844.2429699.67) 27.35 (12.1853.01) 13262.23 (5666.5525855.56) 27.72 (11.9352.85) 0.141 (0.0610.221)
 United Arab Emirates 605.79 (261.91166.61) 32.43 (14.3762.9) 3673.02 (1615.717250.64) 32.66 (14.5662.66) 0.595 (0.5390.652)
 United Kingdom of Great Britain and Northern Ireland 20189.51 (9212.9838291.45) 32.12 (14.5361.12) 22569.46 (10433.3743166.77) 29.68 (13.4956.83) −0.175 (−0.255-0.096)
 United Mexican States 18986.87 (8294.5836185.53) 24.26 (10.7846.68) 30980.59 (13766.2760646.24) 22.78 (10.1444.35) 0.159 (0.1040.214)
 United Republic of Tanzania 6564.14 (2780.4312533.95) 31.4 (13.6859.98) 16552.73 (7046.6130948.84) 31.69 (13.958.02) −0.462 (−0.766-0.157)
 United States of America 53243.81 (23761.75103396.21) 20.05 (8.8938.93) 66485.21 (30210.4128589.32) 18.88 (8.4236.56) −0.054 (−0.1410.032)
 United States Virgin Islands 37.31 (16.371.16) 35.1 (15.4766.63) 30.02 (13.6657.76) 33.13 (14.6264.28) 0.013 (−0.0270.053)
 Yemen 3860.01 (1641.747335.88) 34.93 (15.4265.34) 10713.19 (4605.1520423.85) 34.73 (15.3964.51) 0.376 (0.2310.521)
 Zambia 2241.51 (999.664241.54) 32.86 (14.8762.57) 4792.41 (2112.539542.39) 26.51 (12.0852.64) −0.239 (−0.356-0.122)
 Zimbabwe 2005.05 (857.53790.13) 22.81 (9.9643.9) 3276.83 (1387.676407.95) 23.01 (10.0744.65) 0.241 (0.2110.271)

Abbreviations: DALYs disability-adjusted life years

Gender differences in the disease burden were observed, with females experiencing slightly higher prevalence and DALYs than males, although incidence rates were comparable between sexes (Figure S1, Tables 1, 2 and 3).

Figure 2 depicts the incidence, prevalence, and DALYs for each age group in 2021. The disease burden initially rises with age, peaking in the 20–24 age range, before declining (Figure S2, Tables 1, 2 and 3).

Fig. 2.

Fig. 2

Age-standardized rates of caries of permanent teeth-related incidence, prevalence, and DALYs across countries and territories in 2021. Abbreviations: DALYs, disability-adjusted life years

At the SDI region level, the low-middle SDI region exhibited the highest ASIR at 31,182.47, with a range of 27,260.31 to 35,209.32, whereas the high-middle SDI regions had the lowest ASIRs at 28,068.89, ranging from 24,352.04 to 31,973.91. Notably, ASPR and ASDAR values decreased with increasing SDI region levels, indicating a higher disease burden in less developed regions (Figure S3, Tables 1, 2 and 3). Intriguingly, the age-standardized rates for incidence, prevalence, and DALYs displayed a"W-shaped"relationship with SDI, with peak rates observed when the SDI was approximately 0.75, as depicted in Fig. 1.

Fig. 1.

Fig. 1

Age-standardized rates of incidence, prevalence, and DALYs attributable to caries of permanent teeth across countries and territories by socio-demographic index for both sexes, 1990–2019. The black line was an adaptive association fitted with adaptive Loess regression based on all data points. Abbreviations: DALYs, disability-adjusted-life-years

Regionally, Tropical Latin America had the highest caries of permanent teeth-related ASIR, while East Asia had the lowest, across the 54 GBD regions. Andean Latin America ranked highest in ASPR and ASDAR, with High-income Asia Pacific ranking lowest for prevalence and DALYs (Figure S4, Tables 1, 2 and 3).

At the country level, Cambodia had the highest ASIR, Madagascar had the highest ASPR, and Serbia had the highest ASDAR per 100,000 population in 2021. In contrast, Taiwan (Province of China) had the lowest ASIR, Japan had the lowest ASPR and ASDAR. India reported the highest absolute number of incidence, prevalence, and DALYs cases, while Tokelau had the lowest. These findings highlight the substantial global variation in the disease burden of caries of permanent teeth (Fig. 2, Figure S5, Tables 1, 2 and 3).

Temporal trend for caries of permanent teeth-related disease burden from 1990 to 2021

The number of incidence cases of caries in permanent teeth globally increased from 1990 to 2021, despite a slight decline in the ASIR during the same period. However, the prevalence and DALYs estimates exhibited a contrasting pattern: while cases increased, both the ASPR and ASDAR declined (Fig. 3, Tables 1, 2 and 3).

Fig. 3.

Fig. 3

Trends in the numbers and age-standardized rates of caries of permanent teeth-related incidence, prevalence, and DALYs globally from 1990 to 2021. Abbreviations: DALYs, disability-adjusted-life-years

When examining trends by gender, we found that they mirrored those observed in the overall population consistently (Figure S6, Tables 1, 2 and 3). Similarly, trends across most age groups were also consistent, aligning with the overall population trends (Figure S7, Tables 1, 2 and 3). At the SDI region level, the ASIR increased in low and low-middle SDI regions, whereas it decreased in other SDI regions. In contrast, for ASPR and ASDAR, the middle SDI region demonstrated an upward trend, while other regions showed a declining trend (Figure S8, Tables 1, 2 and 3).

The disease burden associated with caries in permanent teeth varied significantly across GBD regions. In this study, we employed a hierarchical clustering approach to identify locations with similar illness load variations. The results revealed significant increases in ASRs in several regions, including Eastern Africa, Central Europe, and Southeast Asia. Conversely, significant decreases were observed in East Asia and the Western Pacific Region (Figure S9).

When analyzing trends across countries and territories, we noted notable differences. China experienced the most pronounced increase in ASIR from 1990 to 2021, with an EAPC of 1.3 (95% confidence interval: 1.02–1.58). In contrast, Colombia showed the most significant increase in ASPR and ASDAR, with EAPCs of 0.83 (95% CI: 0.46–1.2) and 0.83 (95% CI: 0.47–1.2), respectively. Conversely, Japan exhibited the most notable decrease in ASPR and ASDAR, with an EAPC of −0.53 (95% CI: −0.64 to −0.43). Similarly, Morocco also showed a substantial decline in both ASPR and ASDAR, with EAPCs of −1.17 (95% CI: −1.51 to −0.83) and −1.17 (95% CI: −1.5 to −0.83), respectively (Figure S10, Tables 1, 2 and 3).

The influential factors for EAPC

Our analysis revealed that the EAPCs for caries of permanent teeth are associated with both the ASRs in 1990 and the HDIs in 2021. Specifically, the ASRs in 1990 reflected the existing disease pool at that time, serving as a baseline for comparison. In contrast, the HDIs in 2021 served as indicators of healthcare access and quality across different countries. Notably, we observed a strong correlation between EAPCs and both the ASRs of prevalence and DALYs, suggesting that improvements in oral healthcare and prevention measures have positively contributed to reducing the severity of dental caries. However, no significant relationship was found between EAPCs and HDIs, hinting that factors beyond healthcare may also influence disease trends (Fig. 4).

Fig. 4.

Fig. 4

The association between EAPCs and caries of permanent teeth-related ASRs in 1990 and HDIs in 2021. The circles represent countries that were available on HDI data. The size of the circle is increased with the cases of caries of permanent teeth. The ρ indices and p values presented were derived from Spearman correlation analysis. Abbreviations: EAPC, estimated annual percentage change; ASR, age-standardized rate; HDI, human development index

The predicted results from 2022 to 2046

The predictive outcomes from the BAPC model indicate an increase in the number of incidence cases, prevalence cases, and DALYs for both sexes from 2022 to 2046 (Figure S11 and S12, Table 4). These statistical trends highlight a concerning upward trajectory in the global burden of dental caries. However, it is crucial to interpret these trends within the context of broader systemic factors and public health interventions, as they provide a comprehensive view of the oral health landscape.

Table 4.

The predicted results in the caries of permanent teeth-related numbers and age-standardized rates of incidence prevalence and DALYs by sex globally from 2022 to 2046 of the BAPC model

year sex Age-standardized incidence rate Numer of incidence cases Age-standardized prevalence rate Numer of prevalence cases Age-standardized DALYs rate Numer of DALYs cases
2022 Female 53188.04 2.14E + 09 55264.86 2.18E + 09 53.81832 2168354
2023 Female 53344.26 2.17E + 09 55310.72 2.2E + 09 53.85238 2191887
2024 Female 53514.43 2.2E + 09 55371.25 2.22E + 09 53.89748 2215531
2025 Female 53691.82 2.23E + 09 55440.26 2.24E + 09 53.94964 2239059
2026 Female 53863.96 2.26E + 09 55500.63 2.25E + 09 53.99466 2261730
2027 Female 54038.71 2.29E + 09 55549.82 2.27E + 09 54.03093 2283587
2028 Female 54226.02 2.32E + 09 55606.35 2.29E + 09 54.07156 2305216
2029 Female 54424.92 2.35E + 09 55676.76 2.3E + 09 54.12269 2326876
2030 Female 54629.94 2.38E + 09 55755.12 2.32E + 09 54.18033 2348366
2031 Female 54830.98 2.41E + 09 55825.14 2.34E + 09 54.23099 2368996
2032 Female 55034.41 2.44E + 09 55884.56 2.35E + 09 54.27315 2388806
2033 Female 55248.14 2.48E + 09 55950.58 2.36E + 09 54.31925 2408344
2034 Female 55471.41 2.51E + 09 56029.41 2.38E + 09 54.37504 2427877
2035 Female 55699.85 2.54E + 09 56115.79 2.39E + 09 54.43697 2447247
2036 Female 55925.47 2.57E + 09 56194.61 2.41E + 09 54.49258 2465815
2037 Female 56153.27 2.59E + 09 56263.83 2.42E + 09 54.54045 2483605
2038 Female 56389.47 2.62E + 09 56338.92 2.43E + 09 54.59191 2501121
2039 Female 56633.43 2.65E + 09 56425.54 2.45E + 09 54.65206 2518587
2040 Female 56881.73 2.68E + 09 56518.92 2.46E + 09 54.71764 2535848
2041 Female 57128.16 2.71E + 09 56605.36 2.47E + 09 54.77741 2552323
2042 Female 57376.59 2.74E + 09 56683.03 2.48E + 09 54.83004 2568018
2043 Female 57631.82 2.77E + 09 56765.56 2.49E + 09 54.8856 2583371
2044 Female 57893.36 2.8E + 09 56858.05 2.5E + 09 54.94866 2598562
2045 Female 58158.63 2.83E + 09 56956.48 2.51E + 09 55.01638 2613446
2046 Female 58422.86 2.85E + 09 57048.98 2.52E + 09 55.07914 2627521
2022 Male 52949.52 2.13E + 09 54010.69 2.22E + 09 53.7195 2157543
2023 Male 53209.05 2.16E + 09 53953.73 2.24E + 09 53.79016 2179897
2024 Male 53479.45 2.19E + 09 53912.81 2.26E + 09 53.87247 2202364
2025 Male 53755.91 2.21E + 09 53880.49 2.29E + 09 53.96179 2224744
2026 Male 54030.8 2.24E + 09 53839.54 2.31E + 09 54.04086 2246431
2027 Male 54308.27 2.27E + 09 53788.8 2.33E + 09 54.11099 2267345
2028 Male 54595.39 2.29E + 09 53746.55 2.35E + 09 54.18577 2288045
2029 Male 54891.69 2.32E + 09 53718.59 2.38E + 09 54.27138 2308782
2030 Male 55193.29 2.35E + 09 53698.3 2.4E + 09 54.36334 2329374
2031 Male 55493.93 2.38E + 09 53670.31 2.42E + 09 54.44565 2349244
2032 Male 55797.17 2.4E + 09 53633.63 2.44E + 09 54.5194 2368310
2033 Male 56108.59 2.43E + 09 53604.25 2.46E + 09 54.59723 2387098
2034 Male 56427.83 2.45E + 09 53587.32 2.48E + 09 54.68482 2405863
2035 Male 56751.8 2.48E + 09 53577.23 2.5E + 09 54.77825 2424456
2036 Male 57075.46 2.51E + 09 53560.68 2.52E + 09 54.86327 2442315
2037 Male 57401.76 2.53E + 09 53536.76 2.54E + 09 54.94061 2459363
2038 Male 57735.02 2.56E + 09 53519.03 2.56E + 09 55.0216 2476096
2039 Male 58074.93 2.58E + 09 53511.86 2.57E + 09 55.11117 2492741
2040 Male 58419.04 2.61E + 09 53510.47 2.59E + 09 55.20578 2509152
2041 Male 58763.39 2.63E + 09 53503.54 2.61E + 09 55.29296 2524805
2042 Male 59110.34 2.66E + 09 53490.21 2.63E + 09 55.37312 2539627
2043 Male 59463.17 2.68E + 09 53481.72 2.64E + 09 55.45613 2554062
2044 Male 59821.69 2.71E + 09 53481.81 2.66E + 09 55.54626 2568304
2045 Male 60184.03 2.73E + 09 53486.67 2.67E + 09 55.64059 2582219
2046 Male 60547.12 2.75E + 09 53487.1 2.69E + 09 55.72876 2595344

Abbreviations: DALYs disability-adjusted life years, BAPC Bayesian age-period-cohort

Frontier analysis for ASRs of caries of permanent teeth

Figure 5 presents the unrealized health advancements in the ASRs of caries of permanent teeth, stratified by sociodemographic development levels across various countries and regions from 1990 to 2021. Our analysis uncovered distinct patterns and disparities in the effectiveness of oral health interventions across these strata. Notably, as sociodemographic development progresses, the disparities in caries burden generally widen, indicating a greater potential for improvement among higher SDI nations or regions in 2021. This finding underscores the complex interplay between societal advancement and oral health outcomes, emphasizing the need for targeted interventions tailored to the unique challenges faced by each developmental tier.

Fig. 5.

Fig. 5

Frontier analysis based on SDI and ASRs of the caries of permanent teeth in 2021. The frontier is delineated in solid black color; countries and territories are represented as dots. The top 15 countries with the largest effective difference (largest ASRs gap from the frontier) are labeled in black; examples of frontier countries with low SDI (< 0.5) and low effective difference are labeled in blue, and examples of countries and territories with high SDI (> 0.85) and relatively high effective difference for their level of development are labeled in red. Red dots indicate an increase in age-standardized ASRs from 1990 to 2021; blue dots indicate a decrease in ASRs between 1990 and 2021. Abbreviations: ASRs: Age-Standardized Rates; SDI: Socio-demographic index

Discussion

As far as we know, this was the first study to systematically examine and quantify the global disease burden of caries in permanent teeth. In 2021, it generated a substantial global burden, with considerable disparities across sexes, ages, SDI regions, GBD regions, and countries. Despite global improvements between 1990 and 2021, our forecasted results indicated that the disease burden would rise over the next 25 years. Notably, countries or regions with higher SDIs have greater potential for further improvement in reducing this burden.

Our findings are consistent with previous studies that have documented the global burden of dental caries and emphasized the need for continued efforts to address this prevalent oral health issue [13, 14]. The observed variations in ASIR, ASPR, and ASR of DALYs highlight the complexity of dental caries epidemiology and underscore the importance of considering multiple metrics when assessing disease burden. Future research endeavors should focus on identifying the underlying factors driving these trends, including socioeconomic status [15], access to oral healthcare [16], and lifestyle habits [17]. Specifically, studies could explore innovative approaches such as the use of teledentistry to improve access to care in underserved areas [18], or the development of new materials and technologies for preventive and restorative treatments [19]. Additionally, future research should evaluate the efficacy of current prevention and treatment strategies, such as fluoride varnishes [20], sealants [21], and community-based oral health programs [5]. By investigating these and other potential areas, researchers can further diminish the burden of caries affecting permanent teeth globally.

The observation that the disease burden of the studied condition in 2021 was predominantly higher in females than males, with the exception of incidence cases where the sex gap was minimal, is intriguing and warrants further exploration. This sex disparity in disease burden aligns with previous research that has emphasized the influence of biological, social, and behavioral factors on health outcomes, particularly in the context of chronic and non-communicable diseases [22, 23]. The consistency in trends between males and females, when analyzed separately, mirroring those of the overall population, underscores the uniformity of the disease's epidemiology across sexes. However, the subtle yet significant difference in burden allocation suggests potential sex-specific factors contributing to these disparities. To address these disparities, actionable implications must be considered. For instance, tailored interventions aimed at modifying healthcare-seeking behaviors, improving access to care, and addressing sociocultural norms related to health and illness may be crucial [24]. Furthermore, the negligible sex gap in incidence cases indicates comparable exposure to risk factors between males and females. Yet, the disparity in disease burden, particularly in terms of prevalence and severity, underscores the need for sex-sensitive approaches in disease prevention, diagnosis, and management strategies. By acknowledging and addressing these sex-specific factors, we can strive to achieve more equitable health outcomes for both males and females.

The pattern of disease burden across age groups in 2021 reveals an intriguing trend. The initial increase in incidence, prevalence, and DALYs with age, peaking in the 20–24 age group, followed by a subsequent decline, presents a nuanced view that deserves further attention. While this finding contrasts with many existing studies that typically report a steady rise in disease burden with advancing age, particularly for non-communicable diseases [25], it is important to note that the peak in the 20–24 age group may reflect unique vulnerabilities within this demographic. Factors such as lifestyle choices, exposure to new risk factors, or a combination of biological and social transitions could contribute to this peak. Given this unique trend, it is crucial to consider potential interventions tailored to the needs of the 20–24 age group. Existing evidence suggests that interventions focused on promoting healthy lifestyles, such as regular physical activity, balanced nutrition, and avoiding harmful behaviors (like smoking, excessive alcohol consumption), could be beneficial in reducing disease burden in this population [26]. Additionally, targeted health promotion programs that address the specific risk factors and vulnerabilities of this age group may further enhance their effectiveness. For instance, programs that provide education on mental health, sexual health, and substance abuse prevention could be particularly relevant. While this observation challenges the conventional assumption of a monotonic relationship between age and disease burden, it aligns with emerging research that highlights the complexity of disease burden dynamics across different age groups [27]. The consistency of trends across most age groups further strengthens our understanding of the disease's epidemiology. However, the deviation from the expected trend in the 20–24 age group underscores the importance of nuanced age-specific analysis and highlights the need for targeted interventions and health promotion programs aimed at this vulnerable population.

The disease burden across different SDI regions offers valuable insights into the intricate interplay between socioeconomic development and disease burden. Consistent with prior studies [28, 29], our findings reveal that the lowest-SDI regions face the highest ASIR, potentially due to inadequate healthcare infrastructure, limited access to preventive services, and higher exposure to risk factors. Conversely, the decline in ASIRs observed in high-middle SDI regions may be attributed to better healthcare systems, higher levels of awareness, and improved living conditions. The inverse correlation between ASPR, ASDAR, and SDI levels suggests that as countries progress socioeconomically, they become better equipped to manage the disease, resulting in lower rates of prevalence and DALYs. However, our analysis also uncovers a complex'w-shaped relationship'between ASRs and SDI, with a notable peak around an SDI of 0.75. This finding challenges the simplistic narrative that socioeconomic advancement inevitably leads to reduced disease burden. Instead, it underscores the importance of a nuanced understanding of the transition phases, where middle-SDI regions may experience a surge in disease burden due to rapid urbanization, lifestyle changes, and emerging risk factors. Given this consistent pattern, where disease burden first increases and then decreases with SDI, peaking in middle-SDI regions, it is crucial to implement tailored interventions specifically targeting these critical developmental stages. For middle-SDI regions undergoing rapid urbanization, strategies such as public–private oral health partnerships could be particularly effective in addressing the surge in disease burden. These partnerships can leverage the resources and expertise of both the public and private sectors to enhance access to oral health care services, improve preventive measures, and raise awareness about risk factors. While all SDI regions exhibited an upward trend in the number of cases, indicating an overall increase in global disease burden, the varying trends in ASRs across different SDI regions highlight the importance of context-specific strategies to effectively address this issue. By considering the unique challenges and opportunities presented by different SDI regions, we can develop more targeted and effective interventions to reduce disease burden globally.

The findings underscore the disproportionate distribution of this disease, highlighting the need for targeted interventions in high-burden regions. The observed disparities in caries burden align with previous studies that have emphasized the role of socioeconomic factors, oral hygiene practices, and access to dental care in shaping disease patterns [4]. For instance, the high burden in Tropical and Andean Latin America could be attributed to limited access to preventive services, inadequate oral health education, and barriers to care related to poverty, such as financial constraints, lack of transportation, and unavailability of dental services in rural or underserved areas [30]. Conversely, the relatively low burden in East Asia, particularly in countries like Japan and Taiwan, could be linked to robust public health systems, widespread use of fluoride, and cultural norms favoring oral hygiene [31]. Our analysis further reveals that within countries, the burden of caries has evolved dynamically over time. The notable increase in ASIR in China, for example, underscores the need for continued efforts to improve oral health education and access to dental services, despite recent improvements in overall health indicators [32]. Similarly, the substantial decrease in caries burden in Japan and Morocco highlights the effectiveness of targeted interventions, such as school-based oral health programs and fluoridation policies, in reducing disease prevalence [33, 34]. The hierarchical clustering analysis conducted in this study provides valuable insights into the spatial patterns of caries burden, identifying regions with similar trends in disease burden. This information can inform the development of region-specific strategies for caries prevention and control, leveraging shared challenges and opportunities across neighboring countries. For instance, the observed increase in ASRs across multiple regions, including Eastern Africa and Southeast Asia, suggests a need for intensified efforts to improve oral health infrastructure and access to care in these areas. Moreover, our findings emphasize the importance of considering both incidence and prevalence when assessing the burden of caries. While high incidence rates indicate a need for preventive measures, high prevalence rates underscore the urgency of implementing restorative and rehabilitative services to mitigate the long-term consequences of untreated caries. The substantial number of DALYs attributed to caries in India, for instance, underscores the significant impact of this disease on individual well-being and societal productivity, necessitating a multi-faceted approach to address both prevention and treatment needs.

The observed associations between EAPCs and ASRs in 1990 emphasize the intricate interplay between disease burden and its subsequent trends. Our findings align with previous studies that have emphasized the baseline disease burden as a crucial determinant of future health trajectories [35, 36]. Notably, the positive correlation between EAPCs and ASRs suggests that countries with higher initial caries burdens experienced more pronounced improvements or deteriorations over time, potentially due to variations in health policies, interventions, and resource allocations. While socioeconomic development, as indicated by HDIs, is often considered a key factor in health outcomes, our analysis in 2021 revealed no significant association between EAPCs and HDIs. This divergence challenges the notion that economic progress automatically translates into improved oral health outcomes and underscores the need to consider a broader range of factors. In this context, the importance of targeted interventions and equitable access to oral healthcare services becomes even more evident [37, 38]. Moreover, our results highlight the potential role of other determinants, such as cultural practices, dietary habits, and oral health literacy, in shaping caries trends [39, 40]. The discrepancy between the significant associations with ASRs and the non-significant link to HDIs further underscores the complexity of oral health determinants and emphasizes the need for multi-faceted strategies to address the global burden of caries. In light of these findings, future research should delve deeper into the contextual factors modulating these relationships, including but not limited to the impact of COVID-19 on oral health services, changing lifestyles, and the effectiveness of public health interventions [41, 42]. We believe that a comprehensive understanding of these factors will be crucial in developing effective strategies to improve oral health worldwide.

The projected trends from our BAPC model, predicting a steady rise in incidence, prevalence, and DALYs for both sexes over the next two decades (2022–2046), underscore the pressing need for urgent and sustained interventions. These findings amplify the growing concern voiced in recent literature about the ongoing challenge posed by non-communicable diseases (NCDs) globally [43, 44]. Our projections exceed the anticipated burdens reported in previous studies, highlighting the need for re-evaluation of current strategies and intensification of preventive measures [45, 46]. Demographic shifts, including population aging and lifestyle changes, may exacerbate these trends, necessitating a holistic approach. This approach should address not only clinical management but also behavioral modifications and public health policies aimed at mitigating risk factors [47, 48]. Ultimately, these predictions emphasize the importance of ongoing surveillance, timely adaptation of healthcare systems, and increased investment in research to identify innovative solutions for managing and potentially reversing these distressing trends.

Figure 5 illuminates a complex narrative of unrealized health advancements in ASRs of caries in permanent teeth, stratified by sociodemographic development levels. Our findings resonate with yet challenge the conventional wisdom that societal progress inherently leads to improved oral health. Instead, they underscore a paradox: as sociodemographic indices rise, the gap in caries burden efficacy widens, suggesting that disparities increase with development. This divergence mirrors similar trends reported in global health literature [5, 49], where advancements in certain health metrics do not uniformly translate across socioeconomic strata. Our results emphasize the need for nuanced, tiered approaches to oral health interventions, recognizing that the challenges and opportunities for improvement vary substantially based on a country's or region's developmental status. Such insights underscore the importance of contextualized policies and strategies, tailored to address the specific barriers and facilitators of oral health within each sociodemographic stratum [30].

This study, reliant on the GBD database, encounters limitations primarily stemming from data. The absence of detailed county/province-level data, exemplified by China's vast territory, restricts in-depth analyses [50]. Furthermore, the reliance on secondary data estimated by DisMod-MR introduces uncertainty, particularly in data-scarce countries where estimates may be borrowed from others [51]. To address these limitations in future iterations of the GBD study, we suggest incorporating more primary data sources to enhance the accuracy and robustness of findings. This would involve investing in data collection efforts at more granular geographical levels and improving the methodologies for estimating missing data, particularly in regions with limited data availability.

Conclusion

In conclusion, caries of permanent teeth posed a significant disease burden over the world, particularly in low-income countries. Furthermore, our findings indicated that young adults were at greater risk. We also discovered that the disease burden will continue to rise over the next 25 years, indicating that caries in permanent teeth remained a significant public health issue that needed to be addressed. Countries or areas with a higher SDI have more room to improve their burdens. Stricter mitigation and adaption techniques should be applied and developed to safeguard persons and control caries in permanent teeth.

Supplementary Information

Supplementary Material 2. (260.3KB, docx)

Acknowledgements

We are grateful for the work of the Global Burden of Disease study 2021 collaborators.

Clinical trial number

Not applecable.

Authors’ contributions

Zhiyuan Li: Formal analysis, Investigation, Methodology, Data curation, Software, Investigation, Writing. Chenhang Yu: Conceptualization, Resources, Data curation, Writing, review & editing, Supervision, Project administration. Huan Chen: review & editing.

Funding

None.

Data availability

Data for this study were sourced from the GBD 2021 database. The GBD employs a systematic and standardized approach to estimate health outcomes, including the use of DisMod-MR 2.1, a Bayesian meta-regression tool, to ensure consistency and comparability across locations and time.

Data is provided within the manuscript or supplementary information files.

Declarations

Ethics approval and consent to participate

The study was conducted using publicly available data and did not involve any human subjects or interventions that required direct interaction or manipulation. Therefore, according to the guidelines of our institution's ethics committee, no further ethics approval was required for this type of research. In accordance with the ethical principles outlined in the Declaration of Helsinki, all participants provided informed consent before participating in the study. The anonymity and confidentiality of the participants were guaranteed, and participation was completely voluntary.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Chenhang Yu, Email: 736674091@qq.com.

Huan Chen, Email: 15687233894@163.com.

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Material 2. (260.3KB, docx)

Data Availability Statement

Data for this study were sourced from the GBD 2021 database. The GBD employs a systematic and standardized approach to estimate health outcomes, including the use of DisMod-MR 2.1, a Bayesian meta-regression tool, to ensure consistency and comparability across locations and time.

Data is provided within the manuscript or supplementary information files.


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