Abstract
1. Livers of ureotelic and uricotelic animals possess the capacity, to a varying extent, of hydrolysing l-arginine and other guanidino compounds. 2. Three different enzymes responsible for such activity have been separated and partially characterized. They are the `ureotelic' arginase, the `uricotelic' arginase (both of them specific for l-arginine) and the guanidinobutyrate ureohydrolase (able to hydrolyse β-guanidinopropionate, γ-guanidinobutyrate and d-arginine but not l-arginine or guanidinoacetate). 3. The implication of the advent of a `ureotelic' arginase in the integration of the Krebs–Henseleit cycle is discussed.
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Selected References
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