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. 1965 Sep;96(3):777–780. doi: 10.1042/bj0960777

Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine

N Siliprandi 1, Dagmar Siliprandi 1, M Ciman 1
PMCID: PMC1207216  PMID: 5862415

Abstract

1. Acetylcarnitine added in catalytic amounts to kidney mitochondria produces an active oxidation of endogenous fatty acids. 2. In conditions of mitochondrial `aging', under which acetate is not oxidized, acetylcarnitine also promotes the oxidation of this exogenous substrate. 3. Dinitrophenol completely abolishes the action of acetylcarnitine. 4. Carnitine is ineffective both in the oxidation of endogenous fatty acids and of exogenous acetate. 5. The action of acetylcarnitine is shared, though to a smaller extent, by pyruvate. 6. The mechanism of acetylcarnitine action has been interpreted by considering that the readily oxidizable acetyl group of acetylcarnitine can supply the initial investment of energy needed to start fatty acid oxidation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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