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. 1996 Jun;143(2):713–721. doi: 10.1093/genetics/143.2.713

Destabilization of Simple Repetitive DNA Sequences by Transcription in Yeast

M Wierdl 1, C N Greene 1, A Datta 1, S Jinks-Robertson 1, T D Petes 1
PMCID: PMC1207331  PMID: 8725221

Abstract

Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.

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Selected References

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