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. 1996 Jul;143(3):1231–1241. doi: 10.1093/genetics/143.3.1231

Identification and Genetic Analysis of Wunen, a Gene Guiding Drosophila Melanogaster Germ Cell Migration

N Zhang 1, J Zhang 1, Y Cheng 1, K Howard 1
PMCID: PMC1207393  PMID: 8807296

Abstract

We describe a novel genetic locus, wunen (wun), required for guidance of germ cell migration in early Drosophila development. Loss of wun function does not abolish movement but disrupts the orientation of the motion causing the germ cells to disperse even though their normal target, the somatic gonad, is well formed. We demonstrate that the product of this gene enables a signal to pass from the soma to the germ line and propose that the function of this signal is to selectively stabilize certain cytoplasmic extensions resulting in oriented movement. To characterize this guidance factor, we have mapped wun to within 100 kb of cloned DNA.

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Selected References

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