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. 1996 Jul;143(3):1417–1424. doi: 10.1093/genetics/143.3.1417

Mapping Quantitative Trait Loci for Complex Binary Diseases Using Line Crosses

S Xu 1, W R Atchley 1
PMCID: PMC1207409  PMID: 8807312

Abstract

A composite interval gene mapping procedure for complex binary disease traits is proposed in this paper. The binary trait of interest is assumed to be controlled by an underlying liability that is normally distributed. The liability is treated as a typical quantitative character and thus described by the usual quantitative genetics model. Translation from the liability into a binary (disease) phenotype is through the physiological threshold model. Logistic regression analysis is employed to estimate the effects and locations of putative quantitative trait loci (our terminology for a single quantitative trait locus is QTL while multiple loci are referred to as QTLs). Simulation studies show that properties of this mapping procedure mimic those of the composite interval mapping for normally distributed data. Potential utilization of the QTL mapping procedure for resolving alternative genetic models (e.g., single- or two-trait-locus model) is discussed.

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Selected References

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  1. Bonney G. E. Regressive logistic models for familial disease and other binary traits. Biometrics. 1986 Sep;42(3):611–625. [PubMed] [Google Scholar]
  2. Churchill G. A., Doerge R. W. Empirical threshold values for quantitative trait mapping. Genetics. 1994 Nov;138(3):963–971. doi: 10.1093/genetics/138.3.963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Edwards J. H. Familial predisposition in man. Br Med Bull. 1969 Jan;25(1):58–64. doi: 10.1093/oxfordjournals.bmb.a070672. [DOI] [PubMed] [Google Scholar]
  4. Haley C. S., Knott S. A. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity (Edinb) 1992 Oct;69(4):315–324. doi: 10.1038/hdy.1992.131. [DOI] [PubMed] [Google Scholar]
  5. Jansen R. C. Controlling the type I and type II errors in mapping quantitative trait loci. Genetics. 1994 Nov;138(3):871–881. doi: 10.1093/genetics/138.3.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jansen R. C. Interval mapping of multiple quantitative trait loci. Genetics. 1993 Sep;135(1):205–211. doi: 10.1093/genetics/135.1.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jansen R. C., Stam P. High resolution of quantitative traits into multiple loci via interval mapping. Genetics. 1994 Apr;136(4):1447–1455. doi: 10.1093/genetics/136.4.1447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lange K., Westlake J., Spence M. A. Extensions to pedigree analysis. II. Recurrence risk calculation under the polygenic threshold model. Hum Hered. 1976;26(5):337–348. doi: 10.1159/000152825. [DOI] [PubMed] [Google Scholar]
  9. Mozhaev V. V., Khmelnitsky Y. L., Sergeeva M. V., Belova A. B., Klyachko N. L., Levashov A. V., Martinek K. Catalytic activity and denaturation of enzymes in water/organic cosolvent mixtures. Alpha-chymotrypsin and laccase in mixed water/alcohol, water/glycol and water/formamide solvents. Eur J Biochem. 1989 Oct 1;184(3):597–602. doi: 10.1111/j.1432-1033.1989.tb15055.x. [DOI] [PubMed] [Google Scholar]
  10. Pè M. E., Gianfranceschi L., Taramino G., Tarchini R., Angelini P., Dani M., Binelli G. Mapping quantitative trait loci (QTLs) for resistance to Gibberella zeae infection in maize. Mol Gen Genet. 1993 Oct;241(1-2):11–16. doi: 10.1007/BF00280195. [DOI] [PubMed] [Google Scholar]
  11. Schork N. J., Boehnke M., Terwilliger J. D., Ott J. Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet. 1993 Nov;53(5):1127–1136. [PMC free article] [PubMed] [Google Scholar]
  12. Wang G. L., Mackill D. J., Bonman J. M., McCouch S. R., Champoux M. C., Nelson R. J. RFLP mapping of genes conferring complete and partial resistance to blast in a durably resistant rice cultivar. Genetics. 1994 Apr;136(4):1421–1434. doi: 10.1093/genetics/136.4.1421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wright S. The Results of Crosses between Inbred Strains of Guinea Pigs, Differing in Number of Digits. Genetics. 1934 Nov;19(6):537–551. doi: 10.1093/genetics/19.6.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Zeng Z. B. Precision mapping of quantitative trait loci. Genetics. 1994 Apr;136(4):1457–1468. doi: 10.1093/genetics/136.4.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Zeng Z. B. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10972–10976. doi: 10.1073/pnas.90.23.10972. [DOI] [PMC free article] [PubMed] [Google Scholar]

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