Skip to main content
NCBI home page
Genetics logoLink to Genetics
. 1996 Nov;144(3):957–966. doi: 10.1093/genetics/144.3.957

Regional Bivalent-Univalent Pairing versus Trivalent Pairing of a Trisomic Chromosome in Saccharomyces Cerevisiae

A Koller 1, J Heitman 1, M N Hall 1
PMCID: PMC1207635  PMID: 8913741

Abstract

In meiosis I, homologous chromosomes pair, recombine and segregate to opposite poles. These events and subsequent meiosis II ensure that each of the four meiotic products has one complete set of chromosomes. In this study, the meiotic pairing and segregation of a trisomic chromosome in a diploid (2n + 1) yeast strain was examined. We find that trivalent pairing and segregation is the favored arrangement. However, insertions near the centromere in one of the trisomic chromosomes leads to preferential pairing and segregation of the ``like'' centromeres of the remaining two chromosomes, suggesting that bivalent-univalent pairing and segregation is favored for this region.

Full Text

The Full Text of this article is available as a PDF (1.5 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carle G. F., Olson M. V. Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis. Nucleic Acids Res. 1984 Jul 25;12(14):5647–5664. doi: 10.1093/nar/12.14.5647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Culbertson M. R., Henry S. A. Genetic analysis of hybrid strains trisomic for the chromosome containing a fatty acid synthetase gene complex (fas1) in yeast. Genetics. 1973 Nov;75(3):441–458. doi: 10.1093/genetics/75.3.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hawthorne D C, Mortimer R K. Chromosome Mapping in Saccharomyces: Centromere-Linked Genes. Genetics. 1960 Aug;45(8):1085–1110. doi: 10.1093/genetics/45.8.1085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heitman J., Koller A., Kunz J., Henriquez R., Schmidt A., Movva N. R., Hall M. N. The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Aug;13(8):5010–5019. doi: 10.1128/mcb.13.8.5010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hieter P., Pridmore D., Hegemann J. H., Thomas M., Davis R. W., Philippsen P. Functional selection and analysis of yeast centromeric DNA. Cell. 1985 Oct;42(3):913–921. doi: 10.1016/0092-8674(85)90287-9. [DOI] [PubMed] [Google Scholar]
  6. Hilger F., Mortimer R. K. Genetic mapping of arg1 and arg8 in Saccharomyces cerevisiae by trisomic analysis combined with interallelic complementation. J Bacteriol. 1980 Jan;141(1):270–274. doi: 10.1128/jb.141.1.270-274.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. James A. P., Inhaber E. R. Evidence of preferential pairing of chromosomes at meiosis in aneuploid yeast. Genetics. 1975 Apr;79(4):561–571. doi: 10.1093/genetics/79.4.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kunz J., Hall M. N. Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends Biochem Sci. 1993 Sep;18(9):334–338. doi: 10.1016/0968-0004(93)90069-y. [DOI] [PubMed] [Google Scholar]
  9. Mortimer R. K., Hawthorne D. C. Genetic Mapping in Saccharomyces IV. Mapping of Temperature-Sensitive Genes and Use of Disomic Strains in Localizing Genes. Genetics. 1973 May;74(1):33–54. doi: 10.1093/genetics/74.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mortimer R. K., Schild D. Genetic map of Saccharomyces cerevisiae, edition 9. Microbiol Rev. 1985 Sep;49(3):181–213. doi: 10.1128/mr.49.3.181-213.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mortimer R. K., Schild D. Genetic map of Saccharomyces cerevisiae. Microbiol Rev. 1980 Dec;44(4):519–571. doi: 10.1128/mr.44.4.519-571.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Parry E. M., Cox B. S. The tolerance of aneuploidy in yeast. Genet Res. 1970 Dec;16(3):333–340. doi: 10.1017/s0016672300002597. [DOI] [PubMed] [Google Scholar]
  13. Riley M. I., Manney T. R. Tetraploid Strains of SACCHAROMYCES CEREVISIAE That Are Trisomic for Chromosome III. Genetics. 1978 Aug;89(4):667–684. doi: 10.1093/genetics/89.4.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schild D., Ananthaswamy H. N., Mortimer R. K. An endomitotic effect of a cell cycle mutation of Saccharomyces cerevisiae. Genetics. 1981 Mar-Apr;97(3-4):551–562. doi: 10.1093/genetics/97.3-4.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schmidt A., Hall M. N., Koller A. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol. 1994 Oct;14(10):6597–6606. doi: 10.1128/mcb.14.10.6597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shaffer B., Brearley I., Littlewood R., Fink G. R. A stable aneuploid of Saccharomyces cerevisiae. Genetics. 1971 Apr;67(4):483–495. doi: 10.1093/genetics/67.4.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stearns T., Hoyt M. A., Botstein D. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics. 1990 Feb;124(2):251–262. doi: 10.1093/genetics/124.2.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wickner R. B. Mapping chromosomal genes of Saccharomyces cerevisiae using an improved genetic mapping method. Genetics. 1979 Jul;92(3):803–821. doi: 10.1093/genetics/92.3.803. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES