Skip to main content
Advanced Science logoLink to Advanced Science
. 2025 May 22;12(19):2570140. doi: 10.1002/advs.202570140

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation (Adv. Sci. 19/2025)

Long Zhao, Zhen Shi, Xiaoyu Zhang, Jingting Wang, Shang Yang, Fuyan Wang, Tan Li, Qingjun Zhou, Ting Wang, Weiyun Shi
PMCID: PMC12097072

Abstract

Artificial Cornea Substitutes

In article number 2411540, Qingjun Zhou, Ting Wang, Weiyun Shi, and co‐workers present a humanized corneal substitute using porcine‐cornea templated hydrogel skeletons infused with human ECM and GelMA, achieving light‐activated adhesion. By replicating native stromal hierarchy, it possesses optical/mechanical properties similar to those of natural corneas, and promotes epithelial regeneration and stromal integration. It offers a promising solution to donor shortages and transplant complications.

graphic file with name ADVS-12-2570140-g001.jpg


Articles from Advanced Science are provided here courtesy of Wiley

RESOURCES