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. 1972 Dec;72(4):771–775. doi: 10.1093/genetics/72.4.771

Maintenance of Genetic Variation with a Frequency-Dependent Selection Model as Compared to the Overdominant Model

Philip W Hedrick 1
PMCID: PMC1212870  PMID: 4652882

Abstract

A frequency-dependent selection model proposed by Huang, Singh and Kojima (1971) was found to be more effective at maintaining genetic variation in a finite population than the overdominant model. The fourth moment parameter of the distribution of unfixed states showed that there was a more platykurtic distribution for the frequency-dependent model. This agreed well with the expected gene frequency change found for an infinite population.

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