Abstract
Tissue culture cells of Drosophila melanogaster were given various doses of ultraviolet light. The results indicate that Drosophila cells do have a dark-repair excision mechanism which is not sensitive to caffeine. Pyrimidine dimers were destroyed by photoreactivating illumination in these cells and this destruction probably represents monomerization of the pyrimidine dimers.
Full Text
The Full Text of this article is available as a PDF (316.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BROWNING L. S., ALTENBURG E. The proportionality between mutation rate and ultraviolet dose after photoreactivation in Drosophila. Genetics. 1962 Mar;47:361–366. doi: 10.1093/genetics/47.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bridges B. A. Mechanisms of radiation mutagenesis in cellular and subcellular systems. Annu Rev Nucl Sci. 1969;19:139–178. doi: 10.1146/annurev.ns.19.120169.001035. [DOI] [PubMed] [Google Scholar]
- Buhl S. N., Stillman R. M., Setlow R. B., Regan J. D. DNA chain elongation and joining in normal human and xeroderma pigmentosum cells after ultraviolet irradiation. Biophys J. 1972 Sep;12(9):1183–1191. doi: 10.1016/S0006-3495(72)86154-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cleaver J. E. Photoraactivation: a radiation repair mechanism absent from mammalian cells. Biochem Biophys Res Commun. 1966 Aug 23;24(4):569–576. doi: 10.1016/0006-291x(66)90359-7. [DOI] [PubMed] [Google Scholar]
- Rupp W. D., Howard-Flanders P. Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. J Mol Biol. 1968 Jan 28;31(2):291–304. doi: 10.1016/0022-2836(68)90445-2. [DOI] [PubMed] [Google Scholar]
- Sideropoulos A. S., Shankel D. M. Mechanism of caffeine enhancement of mutations induced by sublethal ultraviolet dosages. J Bacteriol. 1968 Jul;96(1):198–204. doi: 10.1128/jb.96.1.198-204.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]