Abstract
Maximum likelihood methods have been used to compare the fit of twenty different genetic models to experimental data on fourteen characters, each measured on two parental strains, F1 hybrids and both backcrosses. Although variation in all characters was continuous, differentiation between the various models was meaningful, the mean likelihood ratio between the best and worst models for each character being greater than 104. Models with only one or two loci were adequate to account for the observed genetic variation in eleven of the fourteen characters. These results indicate that even in species without special genetic advantages, it may be possible to identify individually some of the genes responsible for naturally-occurring variation within the range of normality.
Full Text
The Full Text of this article is available as a PDF (982.7 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Badr F. M., Shire J. G., Spickett S. G. Genetic variation in adrenal weight: strain differences in the development of the adrenal glands of mice. Acta Endocrinol (Copenh) 1968 Jun;58(2):191–201. doi: 10.1530/acta.0.0580191. [DOI] [PubMed] [Google Scholar]
- Chai C K. Analysis of Quantitative Inheritance of Body Size in Mice. II. Gene Action and Segregation. Genetics. 1956 Mar;41(2):165–178. doi: 10.1093/genetics/41.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]