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. 1973 Sep;75(1):61–73. doi: 10.1093/genetics/75.1.61

Regulation of Phosphate Metabolism in NEUROSPORA CRASSA. Characterization of Regulatory Mutants

John F Lehman 1,2, Mary K Gleason 1,2, Sandra K Ahlgren 1,2, Robert L Metzenberg 1,2
PMCID: PMC1213002  PMID: 4271653

Abstract

A mutant of Neurospora crassa, called UW-6, differs from wild type in being partially constitutive for synthesis of a species of alkaline phosphatase, and also for a species of phosphate permease that has a high affinity for phosphate at high pH. UW-6 is possibly allelic with a mutant called nuc-2 that was previously isolated by Ishikawa. nuc-2 has the converse phenotype, in that it cannot be derepressed for either of these two activities. UW-6 is co-dominant with its wild-type allele in heterokaryons and in partial diploids. An unlinked mutant, nuc-1, is like nuc-2 in that it fails to make the alkaline phosphatase or the permease referred to above. nuc-1 is epistatic to UW-6 in the double mutant. The control of phosphorus metabolism is discussed, and is compared with some other control systems in filamentous fungi.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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