Abstract
Three mutants of Neurospora crassa have been isolated which have altered period lengths of their circadian rhythm of conidiation. The strains, designated "frequency" (frq), were obtained after mutagenesis of the band (bd) strain with N-methyl-N'-nitro-N-nitrosoguanidine. In continuous darkness at 25° bd has a period length of 21.6 ± 0.5 hours; under the same conditions the period length of frq-1 is 16.5 ± 0.5 hours; frq-2, 19.3 ± 0.4 hours; and frq-3, 24.0 ± 0.4 hours. Each of the mutants segregates as a single nuclear gene. All three mutants appear very tightly linked to each other, but it has not yet been determined whether the mutants are allelic. No major changes in the responses to light and temperature have been observed in any of the mutants. It is suggested that these mutants represent alterations in the basic timing mechanism of the circadian clock of Neurospora.
Full Text
The Full Text of this article is available as a PDF (504.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnett A. A circadian rhythm of mating type reversals in Paramecium multimicronucleatum, syngen 2, and its genetic control. J Cell Physiol. 1966 Apr;67(2):239–270. doi: 10.1002/jcp.1040670206. [DOI] [PubMed] [Google Scholar]
- HALBERG F. Temporal coordination of physiologic function. Cold Spring Harb Symp Quant Biol. 1960;25:289–310. doi: 10.1101/sqb.1960.025.01.031. [DOI] [PubMed] [Google Scholar]
- PITTENDRIGH C. S. Circadian rhythms and the circadian organization of living systems. Cold Spring Harb Symp Quant Biol. 1960;25:159–184. doi: 10.1101/sqb.1960.025.01.015. [DOI] [PubMed] [Google Scholar]