Abstract
A method of mapping genes which specify enzymes without the necessity of obtaining genetic variants has been explored. Three enzymes whose structural genes have known genetic positions were chosen to see if the relationship between gene dosage and enzyme activity could be used as a tool in cytological localization. Zw, the gene specifying G6PD, is located in the X chromosome region, 18D-18F. The structural gene for 6PGD, Pgd, maps in the X chromosome bands 2C1-2E1. Idh-NADP, the gene which specifies IDH-NADP, is found on the third chromosome, in bands 66B-67C.
Full Text
The Full Text of this article is available as a PDF (497.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baillie D. L., Chovnick A. Studies on the genetic control of tryptophan pyrrolase in Drosophila melanogaster. Mol Gen Genet. 1971;112(4):341–353. doi: 10.1007/BF00334435. [DOI] [PubMed] [Google Scholar]
- Carlson P. S. Locating genetic loci with aneuploids. Mol Gen Genet. 1972;114(4):273–280. doi: 10.1007/BF00267495. [DOI] [PubMed] [Google Scholar]
- Lindsley D. L., Sandler L., Baker B. S., Carpenter A. T., Denell R. E., Hall J. C., Jacobs P. A., Miklos G. L., Davis B. K., Gethmann R. C. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. doi: 10.1093/genetics/71.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MELLMAN W. J., OSKI F. A., TEDESCO T. A., MACIERA-COELHO A., HARRIS H. LEUCOCYTE ENZYMES IN DOWN'S SYNDROME. Lancet. 1964 Sep 26;2(7361):674–675. doi: 10.1016/s0140-6736(64)92483-3. [DOI] [PubMed] [Google Scholar]
- Seecof R. L., Kaplan W. D., Futch D. G. Dosage compensation for enzyme activities in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1969 Feb;62(2):528–535. doi: 10.1073/pnas.62.2.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steele M. W., Young W. J., Childs B. Genetic regulation of glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster. Biochem Genet. 1969 Aug;3(4):359–370. doi: 10.1007/BF00485720. [DOI] [PubMed] [Google Scholar]
- Tobler J., Bowman J. T., Simmons J. R. Gene modulation in Drosophila: dosage compensation and relocated v + genes. Biochem Genet. 1971 Apr;5(2):111–117. doi: 10.1007/BF00485639. [DOI] [PubMed] [Google Scholar]
- YOUNG W. J., PORTER J. E., CHILDS B. GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN DROSOPHILA: X-LINKED ELECTROPHORETIC VARIANTS. Science. 1964 Jan 10;143(3602):140–141. doi: 10.1126/science.143.3602.140. [DOI] [PubMed] [Google Scholar]
- Young W. J. X-linked electrophoretic variation in 6-phosphogluconate dehydrogenase in Drosophila melanogaster. J Hered. 1966 Mar-Apr;57(2):58–60. doi: 10.1093/oxfordjournals.jhered.a107466. [DOI] [PubMed] [Google Scholar]