Abstract
Approximate conditions for genetic polymorphism in temporally and spatially varying environments are presented for loci which are intermediate at the level of fitness or at the level of gene function. The conditions suggest that polymorphism will be more likely in more variable environments while unlikely in constant environments. Biochemical evidence is presented to justify the assumption of heterozygote intermediacy. Observations on natural populations are cited which substantiate the claim that allozymic polymorphism is primarily due to selection acting on environmental variation in gene function.
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Selected References
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- Carlson P. S. Locating genetic loci with aneuploids. Mol Gen Genet. 1972;114(4):273–280. doi: 10.1007/BF00267495. [DOI] [PubMed] [Google Scholar]
- Chen S. H., Giblett E. R., Anderson J. E., Fossum B. L. Genetics of glutamic-pyruvic transaminase: its inheritance, common and rare variants, population distribution, and differences in catalytic activity. Ann Hum Genet. 1972 Apr;35(4):401–409. [PubMed] [Google Scholar]
- Davidson R. G. Electrophoretic variants of human 6-phosphogluconate dehydrogenase: population and family studies and description of a new variant. Ann Hum Genet. 1967 May;30(4):355–361. doi: 10.1111/j.1469-1809.1967.tb00037.x. [DOI] [PubMed] [Google Scholar]
- Detter J. C., Ways P. O., Giblett E. R., Baughan M. A., Hopkinson D. A., Povey S., Harris H. Inherited variations in human phosphohexose isomerase. Ann Hum Genet. 1968 May;31(4):329–338. doi: 10.1111/j.1469-1809.1968.tb00565.x. [DOI] [PubMed] [Google Scholar]
- Harris H., Hopkinson D. A. Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms. Ann Hum Genet. 1972 Jul;36(1):9–20. doi: 10.1111/j.1469-1809.1972.tb00578.x. [DOI] [PubMed] [Google Scholar]
- Kojima K., Gillespie J., Toari Y. N. A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymes. Biochem Genet. 1970 Oct;4(5):627–637. doi: 10.1007/BF00486100. [DOI] [PubMed] [Google Scholar]
- Levinton J. Genetic variation in a gradient of environmental variability: marine bivalvia (Mollusca). Science. 1973 Apr 6;180(4081):75–76. doi: 10.1126/science.180.4081.75. [DOI] [PubMed] [Google Scholar]
- Long W. K. Glutathione reductase in red blood cells: variant associated with gout. Science. 1967 Feb 10;155(3763):712–713. doi: 10.1126/science.155.3763.712. [DOI] [PubMed] [Google Scholar]
- Luffman J. E., Harris H. A comparison of some properties of human red cell acid phosphatase in different phenotypes. Ann Hum Genet. 1967 May;30(4):387–401. doi: 10.1111/j.1469-1809.1967.tb00040.x. [DOI] [PubMed] [Google Scholar]
- Powell J. R. Genetic polymorphisms in varied environments. Science. 1971 Dec 3;174(4013):1035–1036. doi: 10.1126/science.174.4013.1035. [DOI] [PubMed] [Google Scholar]
- SPENCER N., HOPKINSON D. A., HARRIS H. QUANTITATIVE DIFFERENCES AND GENE DOSAGE IN THE HUMAN RED CELL ACID PHOSPHATASE POLYMORPHISM. Nature. 1964 Jan 18;201:299–300. doi: 10.1038/201299a0. [DOI] [PubMed] [Google Scholar]
- Selander R. K., Yang S. Y. Protein polymorphism and genic heterozygosity in a wild population of the house mouse (Mus musculus). Genetics. 1969 Nov;63(3):653–667. doi: 10.1093/genetics/63.3.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simpson N. E. Factors influencing cholinesterase activity in a Brazilian population. Am J Hum Genet. 1966 May;18(3):243–252. [PMC free article] [PubMed] [Google Scholar]
- Steele M. W., Young W. J., Childs B. Glucose 6-phosphate dehydrogenase in Drosophila malanogaster: starch gel electrophoretic variation due to molecular instability. Biochem Genet. 1968 Sep;2(2):159–175. doi: 10.1007/BF01458714. [DOI] [PubMed] [Google Scholar]