Abstract
Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.
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Selected References
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- Cox E. C., Degnen G. E., Scheppe M. L. Mutator gene studies in Escherichia coli: the mutS gene. Genetics. 1972 Dec;72(4):551–567. doi: 10.1093/genetics/72.4.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cox E. C., Yanofsky C. Altered base ratios in the DNA of an Escherichia coli mutator strain. Proc Natl Acad Sci U S A. 1967 Nov;58(5):1895–1902. doi: 10.1073/pnas.58.5.1895. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Demerec M., Adelberg E. A., Clark A. J., Hartman P. E. A proposal for a uniform nomenclature in bacterial genetics. Genetics. 1966 Jul;54(1):61–76. doi: 10.1093/genetics/54.1.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Donch J. J., Chung Y. S., Green M. H., Greenberg J., Warren G. Genetic analysis of sul mutants of Escherichia coli B. Genet Res. 1971 Jun;17(3):185–193. doi: 10.1017/s0016672300012210. [DOI] [PubMed] [Google Scholar]
- Gibson T. C., Scheppe M. L., Cox E. C. Fitness of an Escherichia coli mutator gene. Science. 1970 Aug 14;169(3946):686–688. doi: 10.1126/science.169.3946.686. [DOI] [PubMed] [Google Scholar]
- Green M. M. The genetics of a mutator gene in Drosophila melanogaster. Mutat Res. 1970 Oct;10(4):353–363. doi: 10.1016/0027-5107(70)90048-5. [DOI] [PubMed] [Google Scholar]
- Hershfield M. S., Nossal N. G. In vitro characterization of a mutator T4 DNA polymerase. Genetics. 1973 Apr;73(Suppl):131–136. [PubMed] [Google Scholar]
- Levins R. Theory of fitness in a heterogeneous environment. VI. The adaptive significance of mutation. Genetics. 1967 May;56(1):163–178. doi: 10.1093/genetics/56.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDonald D J. Segregation of the Selective Advantage Obtained through Orthoselection in Escherichia Coli. Genetics. 1955 Nov;40(6):937–950. doi: 10.1093/genetics/40.6.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nestmann E. R., Hill R. F. Population changes in continuously growing mutator cultures of Escherichia coli. Genetics. 1973 Apr;73(Suppl):41–44. [PubMed] [Google Scholar]