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. 1975 May;80(1):143–155. doi: 10.1093/genetics/80.1.143

Intragenic Deletions and Salivary Band Relationships in Drosophila

W J Welshons 1, D O Keppy 1
PMCID: PMC1213311  PMID: 805754

Abstract

In the absence of assumptions pertaining to the organization and function of chromomeric DNA, the cytogenetic analysis of intragenic deletions that start at Notch and spread to the right or left of the locus suggests that the recombinational gene is bilaterally associated with salivary band 3C7. Either there are two genes resolved as a single cistron, or one must seek an alternative interpretation that allows some modicum of independent in the relationship between gene and band. Although we momentarily lean toward the hypothesis that gene and salivary band are separate entities on a binemic chromosome, alternative views can be devised, and the data must remain open to reinterpretation.—The recessive visible allele faswb behaves as a point mutant at the left end of the map and seems to be a deletion in the interval 3C6 to 7; we suspect some part of the band is missing. We have used the aberration in faswb as a cytological marker, isolated intragenic recombinants, and subjected them to examination. The analysis indicates that the chromosomal interchanges occurred to the right of 3C7.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beermann W. Chromomeres and genes. Results Probl Cell Differ. 1972;4:1–33. doi: 10.1007/978-3-540-37164-9_1. [DOI] [PubMed] [Google Scholar]
  2. Derksen J., Sorsa V. Whole mount electron microscopy of salivary gland chromosomes after treatment with alkaliurea. Exp Cell Res. 1972 Jan;70(1):246–248. doi: 10.1016/0014-4827(72)90207-8. [DOI] [PubMed] [Google Scholar]
  3. Green M. M. The genetics of a mutable gene at the white locus of Drosophila melanogaster. Genetics. 1967 Jul;56(3):467–482. doi: 10.1093/genetics/56.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Henderson S. A. Grades of chromatid organisation in mitotic and meiotic chromosomes. I. The morphological features. Chromosoma. 1971;35(1):28–40. doi: 10.1007/BF00344681. [DOI] [PubMed] [Google Scholar]
  5. Lefevre G., Jr, Green M. M. Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster. Chromosoma. 1972;36(4):391–412. doi: 10.1007/BF00336795. [DOI] [PubMed] [Google Scholar]
  6. Rayle R. E., Green M. M. A contribution to the genetic fine structure of the region adjacent to white in Drosophila melanogaster. Genetica. 1968;39(3):497–507. doi: 10.1007/BF02324482. [DOI] [PubMed] [Google Scholar]
  7. Sorsa V. Whole mount electron microscopy of core fibrils in salivary-gland chromosomes of Drosophila melanogaster. Hereditas. 1972;72(1):169–172. doi: 10.1111/j.1601-5223.1972.tb01039.x. [DOI] [PubMed] [Google Scholar]
  8. Welshons W. J. The cytogenetic analysis of a fractured gene in Drosophila. Genetics. 1974 Apr;76(4):775–794. doi: 10.1093/genetics/76.4.775. [DOI] [PMC free article] [PubMed] [Google Scholar]

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