Abstract
Most of the models of population genetics are not realistic when applied to data on electrophoretic variants of proteins because the same net charge may result from any of several amino acid combinations. In the absence of realistic models they have, however, been widely used to test competing hypotheses about the origin and maintenance of genetic variation in populations. In this paper I present a general method for determining probability generating functions for electrophoretic state differences. Then I use the method to find allelic state difference distributions for selectively similar electrophoretically detectable alleles in finite natural populations.
Predicted patterns of genetic variation, both within and among species, are in reasonable accord with those found in the Drosophila willistoni group by Ayala et al. (1972) and by Ayala and Tracey (1974).
Full Text
The Full Text of this article is available as a PDF (1.5 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ayala F. J., Tracey M. L. Genetic differentiation within and between species of the Drosophila willistoni group. Proc Natl Acad Sci U S A. 1974 Mar;71(3):999–1003. doi: 10.1073/pnas.71.3.999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kirby G. C., Halliday R. B. Another view of neutral alleles in natural populations. Nature. 1973 Feb 16;241(5390):463–464. doi: 10.1038/241463b0. [DOI] [PubMed] [Google Scholar]
- Ohta T., Kimura M. A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res. 1973 Oct;22(2):201–204. doi: 10.1017/s0016672300012994. [DOI] [PubMed] [Google Scholar]