Abstract
137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 x 10-9 per locus per rad.
Full Text
The Full Text of this article is available as a PDF (659.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abrahamson S., Bender M. A., Conger A. D., Wolff S. Uniformity of radiation-induced mutation rates among different species. Nature. 1973 Oct 26;245(5426):460–462. doi: 10.1038/245460a0. [DOI] [PubMed] [Google Scholar]
- Ardashnikov S. N., Soyfer V. N., Goldfarb D. M. Induction of h-mutations in the extracellular phage T2 by gamma-irradiation. Biochem Biophys Res Commun. 1964 Jul 27;16(5):455–459. doi: 10.1016/0006-291x(64)90375-4. [DOI] [PubMed] [Google Scholar]
- Bleichrodt J. F., Verheij W. S. Reversion of cistron A amber mutants of bacteriophage phiX 174 by ionizing radiation. Mutat Res. 1973 Jun;18(3):363–365. doi: 10.1016/0027-5107(73)90220-0. [DOI] [PubMed] [Google Scholar]
- Bresler S. E., Kalinin V. L., Kopylova Y. U., Krivisky A. S., Rybchin V. N., Shelegedin V. N. Study of genetic effects of high energy radiations with different ionizing capacities on extracellular phages. Mutat Res. 1975 Jul;29(1):1–20. doi: 10.1016/0027-5107(75)90017-2. [DOI] [PubMed] [Google Scholar]
- Bridges B. A., Dennis R. E., Munson R. J. Mutagenesis in Escherichia coli. 3. Requirement for DNA synthesis in mutation by gamma rays of T4-phage complexed with Escherichia coli. Genet Res. 1970 Apr;15(2):147–156. [PubMed] [Google Scholar]
- KAPLAN R. W., WINKLER U., WOLF-ELLMAUER H. Induction and reversion of c-mutations by irradiation of the extracellular k-phage of Serratia. Nature. 1960 Apr 23;186:330–331. doi: 10.1038/186330b0. [DOI] [PubMed] [Google Scholar]
- KRIVISKII A. S. MUTAGENNOE DE ISTVIE IONIZIRUIUSHCHIKH IZLUCHENI I NA VNEKLETOCHNY I BAKTERIOFAG. Dokl Akad Nauk SSSR. 1965 Mar 21;161:707–710. [PubMed] [Google Scholar]
- Kondo S., Ichikawa H., Iwo K., Kato T. Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities. Genetics. 1970 Oct;66(2):187–217. doi: 10.1093/genetics/66.2.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawrence C. W., Stewart J. W., Sherman F., Christensen R. Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast. J Mol Biol. 1974 May 5;85(1):137–162. doi: 10.1016/0022-2836(74)90134-x. [DOI] [PubMed] [Google Scholar]
- Munson R. J., Bridges B. A. The LET factor in mutagenesis by ionizing radiations. I. Reversion to wild type of a bacteriophage T4 amber mutant. Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Sep;24(3):257–273. doi: 10.1080/09553007314551101. [DOI] [PubMed] [Google Scholar]
- O'Farrell P. Z., Gold L. M., Huang W. M. The identification of prereplicative bacteriophage T4 proteins. J Biol Chem. 1973 Aug 10;248(15):5499–5501. [PubMed] [Google Scholar]
- Parma D. H., Ingraham L. J., Snyder M. Tandem duplications of the rII region of bacteriophage T4D. Genetics. 1972 Jul;71(3):319–335. doi: 10.1093/genetics/71.3.319. [DOI] [PubMed] [Google Scholar]
- Ripley L. S. Transversion mutagenesis in bacteriophage T4. Mol Gen Genet. 1975 Nov 3;141(1):23–40. doi: 10.1007/BF00332376. [DOI] [PubMed] [Google Scholar]
- Séchaud J., Streisinger G., Emrich J., Newton J., Lanford H., Reinhold H., Stahl M. M. Chromosome structure in phage T4, II. Terminal redundancy and heterozygosis. Proc Natl Acad Sci U S A. 1965 Nov;54(5):1333–1339. doi: 10.1073/pnas.54.5.1333. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weil J., Terzaghi B., Crasemann J. Partial diploidy in phage T41. Genetics. 1965 Sep;52(3):683–693. doi: 10.1093/genetics/52.3.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van der Ent G. M., Blok J., Linckens E. M. The induction of mutations by ionizing radiation in bacteriophage phi-X174 and in its purified DNA. Mutat Res. 1965 Jun;2(3):197–204. doi: 10.1016/0027-5107(65)90028-x. [DOI] [PubMed] [Google Scholar]