Skip to main content
NCBI home page
Genetics logoLink to Genetics
. 1976 Oct;84(2):267–285. doi: 10.1093/genetics/84.2.267

The Genetics of Dopa Decarboxylase in DROSOPHILA MELANOGASTER I. Isolation and Characterization of Deficiencies That Delete the Dopa-Decarboxylase-Dosage-Sensitive Region and the α-Methyl-Dopa-Hypersensitive Locus

Theodore R F Wright 1,2, Ross B Hodgetts 1,2, Allen F Sherald 1,2
PMCID: PMC1213576  PMID: 826447

Abstract

A detailed cytogenetic investigation of 16 overlapping deficiencies in the 36C-40A region on the left arm of the second chromosome (2L) in Drosophila melanogaster is reported. These deficiencies permit a localization of both the dopa-decarboxylase-dosage-sensitive region and the α-methyl-dopa-hypersensitive locus, l(2)amd, to the same region, 37B10-37C7.

Full Text

The Full Text of this article is available as a PDF (1.5 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Karlson P., Sekeris C. E. Ecdysone, an insect steroid hormone, and its mode of action. Recent Prog Horm Res. 1966;22:473–502. doi: 10.1016/b978-1-4831-9825-5.50015-4. [DOI] [PubMed] [Google Scholar]
  2. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  3. Lindsley D. L., Sandler L., Baker B. S., Carpenter A. T., Denell R. E., Hall J. C., Jacobs P. A., Miklos G. L., Davis B. K., Gethmann R. C. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. doi: 10.1093/genetics/71.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lunan K. D., Mitchell H. K. The metabolism of tyrosine-O-phosphate in Drosophila. Arch Biochem Biophys. 1969 Jul;132(2):450–456. doi: 10.1016/0003-9861(69)90388-9. [DOI] [PubMed] [Google Scholar]
  5. McCaman M. W., McCaman R. E., Lees G. J. Liquid cation exchange--a basis for sensitive radiometric assays for aromatic amino acid decarboxylases. Anal Biochem. 1972 Jan;45(1):242–252. doi: 10.1016/0003-2697(72)90024-3. [DOI] [PubMed] [Google Scholar]
  6. O'Brien S. J., Gethmann R. C. Segmental aneuploidy as a probe for structural genes in Drosophila: mitochondrial membrane enzymes. Genetics. 1973 Sep;75(1):155–167. doi: 10.1093/genetics/75.1.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rawls J. M., Jr, Lucchesi J. C. Regulation of enzyme activities in Drosophila. I. The detection of regulatory loci by gene dosage responses. Genet Res. 1974 Aug;24(1):59–72. doi: 10.1017/s001667230001507x. [DOI] [PubMed] [Google Scholar]
  8. SEKERIS C. E., KARLSON P. [on tyrosine metabolism by insects. VII. The catabolic decomposition of tyrosine and the biogenesis of the sclerotizing substance, N-acetyldopamine]. Biochim Biophys Acta. 1962 Jul 30;62:103–113. doi: 10.1016/0006-3002(62)90495-x. [DOI] [PubMed] [Google Scholar]
  9. Sekeris C. E., Herrlich P. Zum Tyrosinstoffwechsel der Insekten. XVII. Der Tyrosinstoffwechsel von Tenebrio molitor und Drosophila melanogaster. Hoppe Seylers Z Physiol Chem. 1966;344(4):267–275. [PubMed] [Google Scholar]
  10. Sherald A. F., Sparrow J. C., Wright T. R. A spectrophotometric assay for Drosophila dopa decarboxylase. Anal Biochem. 1973 Nov;56(1):300–305. doi: 10.1016/0003-2697(73)90194-2. [DOI] [PubMed] [Google Scholar]
  11. Sherald A. F., Wright T. R. The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster. Mol Gen Genet. 1974;133(1):25–36. doi: 10.1007/BF00268674. [DOI] [PubMed] [Google Scholar]
  12. Sparrow J. C., Wright T. R. The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor. Mol Gen Genet. 1974 May 21;130(2):127–141. doi: 10.1007/BF00269084. [DOI] [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES