Skip to main content
NCBI home page
Genetics logoLink to Genetics
. 1977 Feb;85(2):249–257. doi: 10.1093/genetics/85.2.249

Mutagen Specificity in the Induction of Chromosomal Aberrations in Somatic Cells of DROSOPHILA MELANOGASTER

S Pimpinelli 1, D Pignone 1, G Santini 1, M Gatti 1, G Olivieri 1
PMCID: PMC1213628  PMID: 405272

Abstract

The distribution of chromosomal aberrations between and within chromosomes of male D. melanogaster somatic cells after treatment with UV has been analyzed.——Distribution of the breaks between chromosomes was largely nonrandom since we found a higher aberration frequency than that expected on the Y chromosome. Moreover, within the chromosomes the aberrations are clustered in the pericentromeric heterochromatic regions. The above distribution is compared with that of the breaks induced by X rays and methyl-methane-sulphonate (MMS) which were distributed in a different pattern.

Full Text

The Full Text of this article is available as a PDF (465.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Endow S. A., Polan M. L., Gall J. G. Satellite DNA sequences of Drosophila melanogaster. J Mol Biol. 1975 Aug 25;96(4):665–692. doi: 10.1016/0022-2836(75)90145-x. [DOI] [PubMed] [Google Scholar]
  2. Gatti M., Tanzarella C., Olivieri G. Variation with sex of irradiation-induced chromosome damage in somatic cells of Drosophila melanogaster. Nature. 1974 Jan 18;247(5437):151–152. doi: 10.1038/247151a0. [DOI] [PubMed] [Google Scholar]
  3. Griggs H. G., Bender M. A. Photoreactivation of ultraviolet-induced chromosomal aberrations. Science. 1973 Jan 5;179(4068):86–88. doi: 10.1126/science.179.4068.86. [DOI] [PubMed] [Google Scholar]
  4. Hsu T. C. A possible function of constitutive heterochromatin: the bodyguard hypothesis. Genetics. 1975 Jun;79 (Suppl):137–150. [PubMed] [Google Scholar]
  5. Jacobs P. A., Buckton K. E., Cunningham C., Newton M. An analysis of the break points of structural rearrangements in man. J Med Genet. 1974 Mar;11(1):50–64. doi: 10.1136/jmg.11.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Latt S. A., Wohlleb J. C. Optical studies of the interaction of 33258 Hoechst with DNA, chromatin, and metaphase chromosomes. Chromosoma. 1975 Nov 11;52(4):297–316. doi: 10.1007/BF00364015. [DOI] [PubMed] [Google Scholar]
  7. Natarajan A. T., Schmid W. Differential response of constitutive and facultative heterochromatin in the manifestation of mitomycin induced chromosome aberrations in Chinese hamster cells in vitro. Chromosoma. 1971;33(1):48–62. doi: 10.1007/BF00326383. [DOI] [PubMed] [Google Scholar]
  8. Peacock W. J., Brutlag D., Goldring E., Appels R., Hinton C. W., Lindsley D. L. The organization of highly repeated DNA sequences in Drosophila melanogaster chromosomes. Cold Spring Harb Symp Quant Biol. 1974;38:405–416. doi: 10.1101/sqb.1974.038.01.043. [DOI] [PubMed] [Google Scholar]
  9. Pimpinelli S., Gatti M., De Marco A. Evidence for heterogeneity in heterochromatin of Drosophila melanogaster. Nature. 1975 Jul 24;256(5515):335–337. doi: 10.1038/256335a0. [DOI] [PubMed] [Google Scholar]
  10. Pimpinelli S., Pignone D., Gatti M., Olivieri G. X-ray induction of chromatid interchanges is somatic cells of Drosophila melanogaster: variations through the cell cycle of the pattern of rejoining. Mutat Res. 1976 Apr;35(1):101–110. doi: 10.1016/0027-5107(76)90172-x. [DOI] [PubMed] [Google Scholar]
  11. Reich E., Goldberg I. H. Actinomycin and nucleic acid function. Prog Nucleic Acid Res Mol Biol. 1964;3:183–234. doi: 10.1016/s0079-6603(08)60742-4. [DOI] [PubMed] [Google Scholar]
  12. Smyth D. R., Evans H. J. Mapping of sister-chromatid exchanges in human chromosomes using G-banding and autoradiography. Mutat Res. 1976 Apr;35(1):139–154. doi: 10.1016/0027-5107(76)90176-7. [DOI] [PubMed] [Google Scholar]
  13. Trosko J. E., Wilder K. Repair of UV-induced pyrimidine dimers in Drosophila melanogaster cells in vitro. Genetics. 1973 Feb;73(2):297–302. doi: 10.1093/genetics/73.2.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wolff S., Bodycote J., Painter R. B. Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation of different stages of the cell cycle: the necessity for cells to pass through S. Mutat Res. 1974 Oct;25(1):73–81. doi: 10.1016/0027-5107(74)90220-6. [DOI] [PubMed] [Google Scholar]
  15. Wolff S. Chromosome abberations induced by ultraviolet radiation. Photophysiology. 1972;(7):189–205. [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES