Abstract
A model of functional epistasis is proposed in which it is assumed that coupling and repulsion genotypes differ in metabolic efficiency and thus in development time and net fecundity. The implications of this model are investigated for iteroparous populations with fluctuating rates of increase. It is found that the fluctuations in rate of increase can lead to large fluctuations in gamete frequency and D, the coefficient of linkage disequilibrium, but that D will almost always have a value of zero at some point during the populations' demographic cycle. Some of the model populations would be expected to be in a state of linkage disequilibrium only fleetingly: others would exhibit D-cycles interpretable as random fluctuation. Implications of the model for interpretations of existing data on linkage disequilibrium among enzyme loci in Drosophila are discussed.
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Selected References
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- DOBZHANSKY T., LEWONTIN R. C., PAVLOVSKY O. THE CAPACITY FOR INCREASE IN CHROMOSOMALLY POLYMORPHIC AND MONOMORPHIC POPULATIONS OF DROSOPHILA PSEUDOOBSCURA. Heredity (Edinb) 1964 Nov;19:597–628. doi: 10.1038/hdy.1964.73. [DOI] [PubMed] [Google Scholar]
- Mukai T., Yamazaki T. The genetic structure of natural populations of Drosophila melanogaster. X. Developmental time and viability. Genetics. 1971 Nov;69(3):385–398. doi: 10.1093/genetics/69.3.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muki T., Watanabe T. K., Yamaguchi O. The genetic structure of natural populations of Drosophila melanogaster. XII. Linkage disequilibrium in a large local population. Genetics. 1974 Aug;77(4):771–793. doi: 10.1093/genetics/77.4.771. [DOI] [PMC free article] [PubMed] [Google Scholar]