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. 1978 Feb;88(2):327–342. doi: 10.1093/genetics/88.2.327

X-Linked and Autosomal Genes Controlling Mouse α-Galactosidase Expression

Aldons J Lusis 1, John D West 1
PMCID: PMC1213804  PMID: 205481

Abstract

Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse α-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of α-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.

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Selected References

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  1. CHILDS B., ZINKHAM W., BROWNE E. A., KIMBRO E. L., TORBERT J. V. A genetic study of a defect in glutathione metabolism of the erythrocyte. Bull Johns Hopkins Hosp. 1958 Jan;102(1):21–37. [PubMed] [Google Scholar]
  2. Chapman V. M., Shows T. B. Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature. 1976 Feb 26;259(5545):665–667. doi: 10.1038/259665a0. [DOI] [PubMed] [Google Scholar]
  3. Grzeschik K. H., Grzeschik A. M., Banhof S., Romeo G., Siniscalco M., van Someren H., Meera Khan P., Westerveld A., Bootsma D. X-linkage of human -galactosidase. Nat New Biol. 1972 Nov 8;240(97):48–50. doi: 10.1038/newbio240048a0. [DOI] [PubMed] [Google Scholar]
  4. Kozak L. P., McLean G. K., Eicher E. M. X linkage of phosphoglycerate kinase in the mouse. Biochem Genet. 1974 Jan;11(1):41–47. doi: 10.1007/BF00486618. [DOI] [PubMed] [Google Scholar]
  5. Lusis A. J., West J. D. X-linked inheritance of a structural gene for alpha-galactosidase in Mus musculus. Biochem Genet. 1976 Oct;14(9-10):849–855. doi: 10.1007/BF00485346. [DOI] [PubMed] [Google Scholar]
  6. Lyon J. B., Jr, Porter J., Robertson M. Phosphorylase b kinase inheritance in mice. Science. 1967 Mar 24;155(3769):1550–1551. doi: 10.1126/science.155.3769.1550. [DOI] [PubMed] [Google Scholar]
  7. Lyon J. B., Jr The X-chromosome and the enzymes controlling muscle glycogen: phosphorylase kinase. Biochem Genet. 1970 Feb;4(1):169–185. doi: 10.1007/BF00484028. [DOI] [PubMed] [Google Scholar]
  8. Lyon M. F., Hawkes S. G. X-linked gene for testicular feminization in the mouse. Nature. 1970 Sep 19;227(5264):1217–1219. doi: 10.1038/2271217a0. [DOI] [PubMed] [Google Scholar]
  9. Meisler M. H. Effects of the Bgs locus on mouse beta-galactosidase. Biochem Genet. 1976 Dec;14(11-12):921–932. doi: 10.1007/BF00485125. [DOI] [PubMed] [Google Scholar]
  10. Nielsen J. T., Chapman V. M. Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse. Genetics. 1977 Oct;87(2):319–325. doi: 10.1093/genetics/87.2.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Seegmiller J. E., Rosenbloom F. M., Kelley W. N. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science. 1967 Mar 31;155(3770):1682–1684. doi: 10.1126/science.155.3770.1682. [DOI] [PubMed] [Google Scholar]
  12. Valentine W. N., Hsieh H. S., Paglia D. E., Anderson H. M., Baughan M. A., Jaffé E. R., Garson O. M. Hereditary hemolytic anemia associated with phosphoglycerate kinase deficiency in erythrocytes and leukocytes. A probable X-chromosome-linked syndrome. N Engl J Med. 1969 Mar 6;280(10):528–534. doi: 10.1056/NEJM196903062801003. [DOI] [PubMed] [Google Scholar]

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