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. 1978 Apr;88(4):689–707.

A Chromosomal Translocation Causing Overproduction of Iso-2-Cytochrome c in Yeast

Fred Sherman 1,2, Cynthia Helms 1,2
PMCID: PMC1213813  PMID: 206486

Abstract

The CYC7–1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7–1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary structure of iso-2-cytochrome c, and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI. It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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