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. 1979 Jun;92(2):623–646. doi: 10.1093/genetics/92.2.623

Mutation Rates, Population Sizes and Amounts of Electrophoretic Variation of Enzyme Loci in Natural Populations

E Zouros 1
PMCID: PMC1213981  PMID: 488708

Abstract

A method is presented for estimating relative mutation rates or relative effective population sizes, under the hypothesis of adaptively neutral allelic variation. This method was applied to seven surveys of electrophoretic variation. It was observed that electrophoretic mutation rates so obtained follow the gamma distribution and, in Drosophila, are positively correlated with the molecular weights of the enzyme subunits. The variance in mutation rate is larger under the step-wise model of electrophoretic mutation than under the infinite-alleles model. Rates for the most variable loci may exceed rates for less variable loci by a factor of 500. For completely invariant loci, this factor may be as high as 4 x 104, an observation suggesting that these loci are subject to purifying selection. In contrast to mutation rates, effective population sizes may vary at the most by a factor of ten. These results support the hypothesis that differences in the amount of electrophoretic variability among polymorphic loci may reflect differences in the rate by which electrophoretically detectable variation is generated in populations.

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Selected References

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  1. Ayala F. J., Tracey M. L., Barr L. G., McDonald J. F., Pérez-Salas S. Genetic variation in natural populations of five Drosophila species and the hypothesis of the selective neutrality of protein polymorphisms. Genetics. 1974 Jun;77(2):343–384. doi: 10.1093/genetics/77.2.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fuerst P. A., Chakraborty R., Nei M. Statistical studies on protein polymorphism in natural populations. I. Distribution of single locus heterozygosity. Genetics. 1977 Jun;86(2 Pt 1):455–483. [PMC free article] [PubMed] [Google Scholar]
  3. Gillespie J. H., Kojima K. The degree of polymorphisms in enzymes involved in energy production compared to that in nonspecific enzymes in two Drosophila ananassae populations. Proc Natl Acad Sci U S A. 1968 Oct;61(2):582–585. doi: 10.1073/pnas.61.2.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gillespie J. H., Langley C. H. A general model to account for enzyme variation in natural populations. Genetics. 1974 Apr;76(4):837–848. doi: 10.1093/genetics/76.4.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Harris H., Hopkinson D. A., Edwards Y. H. Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy. Proc Natl Acad Sci U S A. 1977 Feb;74(2):698–701. doi: 10.1073/pnas.74.2.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KIMURA M., CROW J. F. THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics. 1964 Apr;49:725–738. doi: 10.1093/genetics/49.4.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Koehn R. K., Eanes W. F. Subunit size and genetic variation of enzymes in natural populations of Drosophila. Theor Popul Biol. 1977 Jun;11(3):330–341. doi: 10.1016/0040-5809(77)90016-8. [DOI] [PubMed] [Google Scholar]
  8. Moran P. A. Wandering distributions and the electrophoretic profile. II. Theor Popul Biol. 1976 Oct;10(2):145–149. doi: 10.1016/0040-5809(76)90012-5. [DOI] [PubMed] [Google Scholar]
  9. Mukai T., Cockerham C. C. Spontaneous mutation rates at enzyme loci in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2514–2517. doi: 10.1073/pnas.74.6.2514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nei M., Chakraborty R., Fuerst P. A. Infinite allele model with varying mutation rate. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4164–4168. doi: 10.1073/pnas.73.11.4164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nei M., Fuerst P. A., Chakraborty R. Testing the neutral mutation hypothesis by distribution of single locus heterozygosity. Nature. 1976 Aug 5;262(5568):491–493. doi: 10.1038/262491a0. [DOI] [PubMed] [Google Scholar]
  12. Stewart F. M. Variability in the amount of heterozygosity maintained by neutral mutations. Theor Popul Biol. 1976 Apr;9(2):188–201. doi: 10.1016/0040-5809(76)90044-7. [DOI] [PubMed] [Google Scholar]
  13. Ward R. D. Relationship between enzyme heterozygosity and quaternary structure. Biochem Genet. 1977 Feb;15(1-2):123–135. doi: 10.1007/BF00484555. [DOI] [PubMed] [Google Scholar]
  14. Zouros E. Electrophoretic variation in allelozymes related to function or structure? Nature. 1975 Apr 3;254(5499):446–448. doi: 10.1038/254446a0. [DOI] [PubMed] [Google Scholar]

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