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. 1979 Jul;92(3):823–832. doi: 10.1093/genetics/92.3.823

Genetic Instability in DROSOPHILA MELANOGASTER: The Induction of Specific Chromosome 2 Deletions by MR Elements

M M Green 1, S H Y Shepherd 1
PMCID: PMC1214039  PMID: 119664

Abstract

We describe the spontaneous induction of deletions by MR elements at the l(2)gl, net, pr and cn loci. The frequent induction of l(2)gl deletions mimics the high frequency of l(2)gl alleles found in wild populations of D. melanogaster. We suggest that these and other data that we present militate for the conclusion that, in the wild, autonomous MR elements occur and function as mutators. We contend that MR elements are not simply the by-products of hybridization between wild and laboratory strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Green M. M. Genetic instability in Drosophila melanogaster: De novo induction of putative insertion mutations. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3490–3493. doi: 10.1073/pnas.74.8.3490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kidwell M. G., Kidwell J. F. Spontaneous male recombination and mutation in isogenic-derived chromosomes of Drosophila melanogaster. J Hered. 1975 Nov-Dec;66(6):367–375. doi: 10.1093/oxfordjournals.jhered.a108649. [DOI] [PubMed] [Google Scholar]
  3. WALLACE B. Allelism of second chromosome lethals in D. melanogaster. Proc Natl Acad Sci U S A. 1950 Nov;36(11):654–657. doi: 10.1073/pnas.36.11.654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Watanabe T. K., Oshima C. Persistence of lethal genes in Japanese natural populations of Drosophila melanogaster. Genetics. 1970 Jan;64(1):93–106. doi: 10.1093/genetics/64.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Wright T. R., Bewley G. C., Sherald A. F. The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants. Genetics. 1976 Oct;84(2):287–310. doi: 10.1093/genetics/84.2.287. [DOI] [PMC free article] [PubMed] [Google Scholar]

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